Acemetacin sustained-release preparation and preparation method

[0029] Embodiment 1-6 prepares 1000 grains / tablet acemetacin sustained-release dosage form

[0030] Drug core composition:

[0031] Example 1 2 3 4 5 6

[0032] Acemetacin 70g 80g 90g 100g 110g 120g

[0033] Microcrystalline Cellulose 105g 120g 135g 150g 165 180g

[0034] Hydroxypropyl methylcellulose 7g 8g 9g 10g 11g 12g

[0035] Controlled release layer composition:

[0036] Composition 1 30% xanthan gum, 70% chitosan;

[0037] Composition 2 40% xanthan gum, 60% chitosan;

[0038] Composition 3 50% xanthan gum, 50% chitosan;

[0039] Composition 4 60% xanthan gum, 40% chitosan;

[0040] Composition 5 70% xanthan gum, 30% chitosan;

[0041] Composition 6 80% xanthan gum, 20% chitosan.

[0042] The above-mentioned controlled-release layer is formulated into a solution with 95% ethanol during spray coating.

[0043] Preparation:

[0044]Any drug core composition in the embodiment of the present invention can choose the above-mentioned multi-layer controlled-release layer with different proportions, as long as the adjacent two layers contain xanthan gum-chitosan in different amounts from each...

[0075] Example 7: Preparation of acemetacin sustained-release dosage form containing a dual-release system of acemetacin sustained-release preparation of the present invention and acemetacin immediate-release preparation

[0076] Acemetacin immediate-release drug formulation prescription

[0077] Acemetacin 30g Sucrose powder 40g Micropowder silica gel 0.75g 50% ethanol amount

[0078] Preparation method of acemetacin immediate release drug preparation

[0079] Weigh acemetacin, sucrose powder, and micropowdered silica gel, mix evenly, add 50% ethanol to make granules, dry at 60±5°C, and take granules between 20-40 mesh for later use;

[0080] Preparation of Acemetacin Dual Delivery System Preparation

[0081] Weigh the acemetacin quick-release preparation and the sustained-release preparation of the present invention, add magnesium stearate, mix uniformly, pack into capsules or compress tablets.