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Application of dimethylaminobenzaldehyde thiosemicarbazide in the whitening cosmetics

A technology of formaldehyde thiosemicarbazone and dimethylaminobenzene, which is applied in the field of whitening cosmetics, can solve the problems of difficult extraction and processing, complex components of natural extracts, etc.

Active Publication Date: 2007-09-26
GUANGZHOU TUOLONG BIOTECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the whitening agents of the main whitening cosmetics on the market generally use natural extracts, but the components of natural extracts are complex, which makes extraction and processing difficult
The chemically synthesized whitening agent is conducive to mass production, its production process is simple, and the whitening effect is fast and significant, but it is easy to have safety problems, which cannot be ignored.

Method used

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  • Application of dimethylaminobenzaldehyde thiosemicarbazide in the whitening cosmetics
  • Application of dimethylaminobenzaldehyde thiosemicarbazide in the whitening cosmetics
  • Application of dimethylaminobenzaldehyde thiosemicarbazide in the whitening cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 4g of marine fish collagen peptide and add 20ml of distilled water, mix well to obtain solution A. Weigh 0.3g of methyl paraben and 0.05g of p-dimethylaminobenzaldehyde thiosemicarbazone, add 1.5ml of ethanol, mix well, then add 18ml of glycerin, 1.5ml of propylene glycol, mix well to obtain solution C. Mix solution A and solution C, add 30ml of distilled water, and then add 3.1μl of essence, mix well and serve as anti-wrinkle and whitening lotion.

Embodiment 2

[0034] Weigh 6g of marine fish collagen peptide and add 20ml of distilled water, mix well to obtain solution A. Weigh 0.25g of methyl paraben and 0.035g of p-dimethylaminobenzaldehyde thiosemicarbazone, add 1.0ml of ethanol, mix well, then add 25ml of glycerin, 1.2ml of propylene glycol, mix well to obtain solution C. Mix solution A and solution C, add 20ml of distilled water, then add 4.5μl of essence, mix well and serve as whitening lotion.

Embodiment 3

[0036] Weigh 2.5g marine fish collagen peptide and add 20ml distilled water, mix well to obtain solution A. Weigh 0.15g of methyl paraben and 0.028g of p-dimethylaminobenzaldehyde thiosemicarbazone, add 1.2ml of ethanol, mix well, then add 18ml of glycerin, 1.2ml of propylene glycol, mix well to obtain solution C. Mix solution A and solution C, add 30ml of distilled water, then add 5.0μl of essence, mix well and serve as whitening lotion.

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Abstract

The invention relates to a paradimethy-laminobenzaldehyde thiosemicarbazone as tyrosinase restrainer, in particular to the paradimethy-laminobenzaldehyde thiosemicarbazone applied in beauty cosmetics. The invention uses paradimethy-laminobenzaldehyde thiosemicarbazone with high-effect restrain function on the activity of tyrosinase as whitening agent to prepare beauty cosmetics, and provides a relative beauty cosmetics and a preparation. The invention uses paradimethy-laminobenzaldehyde thiosemicarbazone as whitening agent of de-crease beauty cosmetics solution which contains sea fish collagen peptide, paradimethy-laminobenzaldehyde thiosemicarbazone, alcohol, glycerin, methyl glycol, plant essence, conservative and water, that dissolves sea fish collagen peptide into water to obtain solution A, dissolves conservative and paradimethy-laminobenzaldehyde thiosemicarbazone into alcohol to obtain solution B, adds glycerin and methyl glycol into solution B to obtain solution C, mixes the solutions A and C, and adds water to form solution D, and adds plant essence into the solution D.

Description

technical field [0001] The invention relates to a p-dimethylaminobenzaldehyde thiosemicarbazone as a tyrosinase inhibitor, in particular to the application of p-dimethylaminobenzaldehyde thiosemicarbazone as a whitening agent in whitening cosmetics. Background technique [0002] Tyrosinase widely exists in organisms and is the key enzyme of melanin biosynthesis (Mayer AM, Harel E.Phenoloxidases and their significance in fruit and vegetables. Food Enzymology, Fox P F.Ed, Elsevier; London, 1998, 373-398) In living organisms, tyrosinase firstly hydroxylates tyrosine to generate L-DOPA, then oxidizes L-DOPA to generate dopaquinone, and dopaquinone undergoes a series of enzymatic and non-enzymatic reactions to form melanin . Therefore, tyrosinase is the rate-limiting enzyme of melanin synthesis, its activity is related to the amount of melanin synthesis, and the amount of melanin production can be regulated by regulating its activity (Friedman M.Food browning and its prevention:...

Claims

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Application Information

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IPC IPC(8): A61K8/46A61Q19/04A61Q19/08
Inventor 宋康康陈清西王勤蒋哲邱凌
Owner GUANGZHOU TUOLONG BIOTECH DEV
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