Self microemulsion preparation of Rubescensin A, and preparation method

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oridonin self-microemulsion drug delivery system and a preparation method thereof. Background technique [0002] Rabdosia rubescens (Hemsl1) Hara (synonym Isodon rubescens (Hemsl1) C1Y1Wu et Hsuan), is a plant of the genus Lamiaceae, which is widely distributed in the Yellow River Basin and the vast areas to the south of China. Sweet and bitter in taste, slightly cold in nature, it has the functions of clearing away heat and relieving exterior, reducing inflammation and relieving pain, invigorating stomach, activating blood circulation and anti-tumor. Oridonin (Oridonin) is a natural compound of kaurene diterpenoids extracted and isolated from Oridonin. It is a colorless prismatic crystal with a very bitter taste and is insoluble in water. The methyl-conjugated cyclopentanone structure is the anti-cancer active center, and the effect disappears when the ring is split ...