Novel composing prescription sustained-release preparation for treating high blood pressure and preparation method thereof

[0024] Example 1 Compound Metoprolol Eprosartan Tartrate Double-Layer Sustained Release Tablets

[0025] prescription:

[0026] components

content

Metoprolol tartrate

Eprosartan

HPMC-15M

EC

lactose

80% ethanol solution

microcrystalline cellulose

purified water

Talc powder

Co-made

100g

600g

80g

20g

30g

Appropriate amount

200g

Appropriate amount

Appropriate amount

1000 pieces

[0027] Preparation:

[0028] Pass metoprolol tartrate through a 100-mesh sieve, HPMC-15M, EC, and lactose pass through a 60-mesh sieve, mix the raw and auxiliary materials evenly, use 80% ethanol solution to make a soft material, granulate with a 16-mesh sieve, dry at 40°C, and use a 16-mesh sieve Whole the granules, add talcum powder and mix evenly, and set aside; in addition, mix eprosartan and microcrystalline cellulose evenly, ...

[0029] Example 2 Compound Metoprolol Irbesartan Tartrate Double-Layer Sustained Release Tablets

[0030] prescription:

[0031] components

content

Metoprolol tartrate

Irbesartan

HPMC-15M

HPMC-100M

sucrose

80% ethanol solution

lactose monohydrate

purified water

100g

150g

60g

15g

30g

Appropriate amount

80g

Appropriate amount

[0032] Micropowder silica gel

Co-made

Appropriate amount

1000 pieces

[0033] Preparation:

[0034] Pass metoprolol tartrate through a 100-mesh sieve, HPMC-15M, HPMC-100M, and sucrose pass through a 60-mesh sieve, mix the raw and auxiliary materials evenly, and use 80% ethanol solution to make a soft material, granulate with a 16-mesh sieve, dry at 40°C, and dry at 16 Mesh sieve for granulation, add some micropowder silica gel and mix evenly, and set aside; in addition, mix irbes...

[0035] Example 3 Compound metoprolol candesartan medoxomil tartrate film-coated sustained-release tablet

[0036] Prescription for Metoprolol Tartrate Tablets:

[0037] components

content

Metoprolol tartrate

microcrystalline cellulose

lactose

purified water

Co-made

100g

250g

75g

Appropriate amount

1000 pieces

[0038] Coating prescriptions containing candesartan cilexetil:

[0039] components

content

candesartan cilexetil

Ethyl cellulose

Acrylic RS100

Tween ~ 80

Talc powder

Anhydrous ethanol solution

4g

12g

15g

2g

4g

400ml

[0040] Preparation:

[0041] Pass metoprolol tartrate through a 100-mesh sieve, microcrystalline cellulose and lactose through a 60-mesh sieve, mix the raw and auxiliary materials evenly, make soft materials with appropriate amount of water, granulat...