Supercharge Your Innovation With Domain-Expert AI Agents!

Aerosol and injectable formulations of nanoparticulate benzodiazepine

A benzodiazepine and nanoparticle technology, applied in aerosol delivery, nanotechnology, nanotechnology, etc., can solve problems such as undescribed benzodiazepine compositions

Inactive Publication Date: 2008-05-28
ELAN PHRMA INT LTD
View PDF80 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The '684 patent also describes methods for preparing such nanoparticulate compositions, but does not describe compositions containing benzodiazepines such as lorazepam in nanoparticulate form

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0262] The purpose of this example was to prepare a nanoparticulate benzodiazepine such as lorazepam formulation.

[0263] 10% (w / w) lorazepam mixed with 2% (w / w) polyvinylpyrrolidone (PVP) K29 / 32 and 0.05% (w / w) dioctyl sulfosuccinate (DOSS) The aqueous dispersion was milled together with 500 micron PolyMill(R) milling media (Dow Chemical Co.) (89% media loading) in a 10 ml NanoMill(R) 0.01 chamber (NanoMill Systems, King of Prussia, PA; see eg, US Patent No. 6,431,478). In an exemplary method, the mixture may be milled for 60 minutes at a speed of 2500 rpm.

[0264] After milling, the particle size of the milled lorazepam particles can be measured with a Horiba LA 910 Particle Size Analyzer in deionized distilled water. The milled lorazepam initial average particle size is desirably less than 2000 nm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Described herein are nanoparticulate formulations of benzodiazepines, such as lorazepam, which do not require the presence of polyethylene glycol and propylene glycol as stabilizers; and methods of making and using such formulations. The formulation is especially useful in aerosol and injectable dosage forms and contains nanoparticulate benzodiazepines such as lorazepam and at least one surface stabilizer. The preparation is useful in the treatment of epileptic states, in the treatment of irritable bowel syndrome, sleep induction, acute psychosis and as a pre-anesthesia drug.

Description

field of invention [0001] The present invention relates to nanoparticle benzodiazepines, preferably nanoparticle lorazepam aerosol and injection preparation. The compositions of the invention are useful in the treatment of epileptic states, sleep induction, acute psychosis, irritable bowel syndrome and for pre-anesthesia administration. The invention also includes methods of making and using such compositions. Background of the invention [0002] I. Route of administration [0003] The route of administration of a drug is critical to its pharmacological efficacy. Various routes of administration are available, and all have advantages and disadvantages. Oral administration of tablets, capsules, liquid formulations, etc. is the most convenient method of drug delivery, but many pharmaceutical compounds are not suitable for oral administration. For example, modern protein drugs that are unstable in the acidic gastric environment or are rapidly degraded by proteolytic enzyme...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/14A61K9/10
CPCA61K9/0019A61K9/145A61K9/146A61K9/0043A61K9/0073A61K31/5513A61P1/00A61P23/00A61P25/00A61P25/08A61P25/18A61P25/20A61K9/14A61K9/10B82Y5/00
Inventor G·利弗西奇S·詹金斯
Owner ELAN PHRMA INT LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com