Composition containing telmisartan and preparing method thereof

[0049] Telmisartan 40g

[0050] Polyvinylpyrrolidone 12g

[0051] Meglumine 12g

[0052] Sodium hydroxide 3.36g

[0053] Microcrystalline Cellulose 80g

[0054] Mannitol 90g

[0055] Cross-linked polyvinylpyrrolidone 40g

[0056] Magnesium Stearate 5g

[0057] Dissolve the above amount of telmisartan, meglumine, sodium hydroxide and polyvinylpyrrolidone in 95% ethanol-water solution (4:1) (about 110 ml) to obtain a uniform solution. Pass the above amount of mannitol, microcrystalline cellulose and cross-linked polyvinylpyrrolidone through a 60-mesh sieve, and then mix uniformly to obtain a granular mixture. The resulting particle mixture is placed in a fluidized bed and sprayed with the above homogeneous solution. The granules sprayed with the solution are dried and passed through a 24-mesh sieve for sizing, then the above-mentioned amount of magnesium stearate is added, mixed evenly, and compressed into tablets to obtain 1000 tablets of the preparation.

[0059] Telmisartan 40g

[0060] Sodium hydroxide 3.5g

[0061] Meglumine 8.5g

[0062] Polyvinylpyrrolidone (K30) 16.0g

[0063] Microcrystalline Cellulose 70g

[0064] Cross-linked polyvinylpyrrolidone 34g

[0065] Mannitol: 40g

[0066] Magnesium stearate: 5g

[0067] Dissolve the above amount of telmisartan, meglumine, sodium hydroxide and polyvinylpyrrolidone in 95% ethanol-water solution (4:1) (about 110 ml) to obtain a uniform solution. Pass the above amount of mannitol, microcrystalline cellulose and cross-linked polyvinylpyrrolidone through a 60-mesh sieve, and then mix uniformly to obtain a granular mixture. The resulting particle mixture is placed in a fluidized bed and sprayed with the above homogeneous solution. The granules sprayed with the solution are dried and passed through a 24-mesh sieve for sizing, then the above-mentioned amount of magnesium stearate is added, mixed evenly, and compressed into tablets to obtain 1000 tablets of the preparation.

[0069] Telmisartan 40g

[0070] Sodium hydroxide 6g

[0071] Meglumine 12g

[0072] Polyvinylpyrrolidone (K30) 8.0g

[0073] Microcrystalline Cellulose 80g

[0074] Cross-linked polyvinylpyrrolidone 40g

[0075] Mannitol 14g

[0076] Magnesium stearate 0.2g

[0077] Dissolve the above amount of telmisartan, meglumine, sodium hydroxide and polyvinylpyrrolidone in 95% ethanol-water solution (4:1) (about 110 ml) to obtain a uniform solution. Pass the above amount of mannitol, microcrystalline cellulose and cross-linked polyvinylpyrrolidone through a 60-mesh sieve, and then mix uniformly to obtain a granular mixture. The resulting particle mixture is placed in a fluidized bed and sprayed with the above homogeneous solution. The granules sprayed with the solution are dried and passed through a 24-mesh sieve for sizing, then the above-mentioned amount of magnesium stearate is added, mixed evenly, and compressed into tablets to obtain 1000 tablets of the preparation.