Daimeton (sodium) suspension injection and preparation thereof
A technology of sulfamethoxine and sodium methotrexate, which is applied in the field of suspensions, can solve the problems of short half-life, strong irritation, and inconvenient administration of animals, and achieve improved curative effect, improved production performance, and improved bioavailability degree of effect
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Embodiment 1
[0022] ①20% Sulfamethoxine Suspension Injection
[0023] A kind of sulfamethoxine suspension injection, its full prescription is:
[0024] Sulfamethoxine 200g
[0025] Aluminum stearate 3g
[0026] Oily vehicle up to 1000ml
[0027] The preparation method of described sulfamethoxine suspension injection is carried out as follows:
[0028] Take 1000ml of oily medium, sterilize at 150°C for 1h, cool to below 60-80°C, and set aside; take 3g of aluminum stearate, soak in 500ml of sterilized oily medium, heat to 120°C, keep for 1h, stir to make stearin Acid aluminum oil gel, cooled to below 50°C; add the prescribed amount of sulfamethoxine, stir evenly, put it in a colloid mill and grind for 30 minutes, add sterilized oily solvent to the full amount, mix evenly, filter with a 200-mesh silk sieve, and While stirring, it was divided into ground glass bottles, covered with rubber stoppers, crimped caps, and sterilized by autoclaving at 121°C for 20 minutes.
[0029] ②20% Sulfamet...
Embodiment 2
[0037] ①1% Sulfamethoxine Suspension Injection
[0038] A kind of sulfamethoxine suspension injection, its full prescription is:
[0039] Sulfamethoxine 10g
[0040] Aluminum stearate 3g
[0041] Oily vehicle up to 1000ml
[0042] The preparation method of described sulfamethoxine suspension injection is carried out by the preparation method described in Example 1.
[0043] ②1% Sulfamethoxine Sodium Suspension Injection
[0044] A kind of sulfamethoxine sodium suspension injection, its complete prescription is:
[0045] Sulfamethoxine Sodium 10g
[0046] Aluminum stearate 3g
[0047] Oily vehicle up to 1000ml
[0048] The preparation method of described sulfamethoxine sodium suspension injection is carried out by the preparation method described in Example 1.
Embodiment 3
[0050] ①50% Sulfamethoxine Suspension Injection
[0051] A kind of sulfamethoxine suspension injection, its full prescription is:
[0052] Sulfamethoxine 500g
[0053] Aluminum stearate 3g
[0054] Oily vehicle up to 1000ml
[0055] The preparation method of described sulfamethoxine suspension injection is carried out by the preparation method described in Example 1.
[0056] ②50% Sulfamethoxine Sodium Suspension Injection
[0057]A kind of sulfamethoxine sodium suspension injection, its complete prescription is:
[0058] Sulfamethoxine Sodium 500g
[0059] Aluminum stearate 3g
[0060] Oily vehicle up to 1000ml
[0061] The preparation method of described sulfamethoxine sodium suspension injection is carried out by the preparation method described in Example 1.
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