Preparation of N(2)-L-alanyl-L-glutamine

technical field [0001] The present invention relates to a method for preparing dipeptides containing up to 4 amino acids, especially N(2)-L-alanyl-L-glutamine. Background technique [0002] Amide amino acids are an extremely useful class of amino acids. For example, glutamine has many important physiological functions: it can promote the proliferation of gastrointestinal mucosal cells and maintain the integrity of the intestinal tract; the phagocytosis of macrophages, the proliferation of lymphocytes and the synthesis of proteins must rely on sufficient glutamine . Under normal circumstances, the human body can synthesize glutamine to meet its own needs. However, under stress conditions such as major trauma and severe infection, the body is in an ultra-high metabolic state, and the body's glutamine pool is severely consumed. At the same time, other tissues and organs such as the small intestine and lymphocytes increase the intake of glutamine in the blood. , so that plasm...