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Local application emplastrum containing heparin and diclofenac

A technology for topical application, diclofenac, applied in medical preparations containing active ingredients, organic active ingredients, nervous system diseases, etc.

Inactive Publication Date: 2009-12-23
ALTERGON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] This type of patch represents an alternative delivery system for the oral administration of diclofenac, which is known to produce a number of undesirable side effects at the gastrointestinal level

Method used

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  • Local application emplastrum containing heparin and diclofenac
  • Local application emplastrum containing heparin and diclofenac

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Embodiment Construction

[0013] According to the plaster of the present invention, wherein diclofenac is usually used in the form of a pharmaceutically acceptable salt, and preferably the salt of a heterocyclic amine represented by the following general formula:

[0014]

[0015] where m is 0 or 1.

[0016] According to a particularly preferred embodiment, the heterocyclic amine is N-hydroxyethylpyrrolidine (pyrrolethanol).

[0017] According to the plaster of the present invention, the concentration range of the diclofenac salt is usually 0.1-5wt% of the total weight of the composition used for hydrogel matrix preparation, and the preferred concentration is 0.3-3wt%.

[0018] According to a particularly preferred embodiment, the concentration of diclofenac is 1.3% by weight of the total weight of the composition for hydrogel matrix formulation.

[0019] When the plaster of the present invention contains heparin, it is preferably one with a molecular weight of 5,000-30,000 DA.

[0020] The concen...

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Abstract

The invention relates to a local application emplastrum with analgesic activity and simultaneously capability of enabling hematoma reabsorption, which comprises a basal layer, a pharmaceutically acceptable diclofenac salt, a hydrogel matrix form adhesion layer with heparin or heparitin, and a protective membrane capable of being removed in use.

Description

technical field [0001] The invention relates to a topical patch with analgesic activity and hematoma reabsorption, comprising diclofenac and heparin or diclofenac and a heparinoid. Background technique [0002] Known and available on the market for topical treatment of hematoma resorption and ecchymosis are heparin analog based emulsions, possibly in combination with hyaluronidase. [0003] Although effective, these emulsions suffer from a number of disadvantages. In fact, they did not exhibit the more specific analgesic activity that would be particularly desirable for the treatment of severe ecchymosis. [0004] In addition, the use of the emulsion involves first applying the emulsion and then rubbing or gently rubbing the applied area, which prevents the active ingredient from being evenly administered to different skin parts. [0005] Furthermore, preparations of this type do not allow controlled release of the active ingredient; therefore, these preparations must be a...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/196A61K31/727A61P25/04A61P29/00
Inventor 伊丽莎白·多纳蒂伊琳娜·拉帕波特
Owner ALTERGON
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