Application of cornflower-3-O-galactoside in preparing foods or medicaments for improving cognitive functions of old people

[0020] Effect evaluation: Experimental study of cyanidin-3-O-galactoside in improving cognitive function in aged mice

[0021] There were 14 15-month-old SPF Kunming mice, half male and half male. After adaptive feeding for 1 week, they were divided into control group and cyanidin-3-O-galactoside group (monomer group) according to body weight, with 7 animals in each group. Mice in the control group were given distilled water; the dose of monomer group was 50 mg / kg bw·d. The experimental period is 6w.

[0022] The experimental results showed that (1) compared with the control group, the dark avoidance latency of the mice in the monomer group was significantly prolonged; (2) compared with the control group, the escape latency of the mice in the monomer group was significantly shortened in the Morris water maze; The duration of the quadrant is significantly extended, and the number of crossing platforms is significantly increased. It is suggested that the supplementation of cy...

[0027] Efficacy Evaluation: Experimental Study on the Reduction of Peroxidative Damage of Hippocampal Nerve Cells by Cyanide-3-O-Galactoside

[0028] Isolate and culture the hippocampal neurons of newborn suckling mice, add 50μmol / LH 2 o 2 Establishment of oxidative stress injury model (H 2 o 2 Model group); 1 μg / ml cyanidin-3-O-galactoside (monomer group) was added to the culture medium. The LDH activity, neuronal survival rate and apoptosis rate in the cell supernatant were measured.

[0029] The results showed that, with H 2 o 2 Compared with the model group, the LDH activity in the supernatant of hippocampal nerve cells in the monomer group was significantly reduced; the apoptosis rate of nerve cells was significantly reduced. Prompt cyanidin-3-O-galactoside can significantly inhibit H 2 o 2 Induced apoptosis of hippocampal neurons, on H 2 o 2 Injury to hippocampal nerve cells has a protective effect.

[0031] The cyanidin-3-O-galactoside and pharmaceutically acceptable auxiliary materials are prepared into convenient effervescent tablets, chewable tablets, capsules or injections according to conventional techniques.