7,2'-dehydration puerarin, salt derivatives as well as preparation method and application thereof
A technology of puerarin and derivatives, applied in the field of medicine, can solve problems such as undiscovered, achieve the effects of enhancing absorption, improving cell membrane permeability, and good application prospects
Inactive Publication Date: 2010-12-22
SHANDONG UNIV
View PDF3 Cites 3 Cited by 
- Summary
 - Abstract
 - Description
 - Claims
 - Application Information
 
 AI Technical Summary 
Problems solved by technology
However, after retrieval, no reports of 7,2"-anhydropuerarin derivatives have been found
Method used
 the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine 
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
 Experimental program 
 Comparison scheme 
 Effect test 
Embodiment 1
Embodiment 2
Embodiment 3
 the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine 
 Login to View More PUM
 Login to View More Abstract
The invention relates to a compound 7,2''-dehydration puerarin in a structural formula (I) and salt derivatives thereof. The 7,2''-dehydration puerarin is prepared from puerarin through intramolecular Mitsunobu reaction. The invention can remarkably reduce the arrhythmia duration and prolong the cogulation time. The monomer compound and medical salts thereof can be prepared into orally-taken or injection agents and can be used for treating cardiovascular and cerebrovascular diseases of arrhythmia, coronary disease, angina, myocardial infarction, cerebral infarction, and the like.
Description
technical field   The invention relates to puerarin derivatives and their preparation methods and applications, in particular to 7,2"-anhydropuerarin and its salt derivatives and their preparation methods and applications, belonging to the technical field of medicine.   Background technique   Puerarin is a kind of isoflavone glycoside extracted from the roots of Pueraria mirifica and Pueraria vine, which is a leguminous plant. Studies have found that it can scavenge free radicals (J.Agric.Food Chem.2002, 50, 7504-7509.), lower serum cholesterol  (J.Nat.Prod.2003, 66, 788-792.), anticoagulant and antiallergic (Biol.Pharm.Bull.2002, 25, 1328-1332.) and other activities, clinically used for the treatment of coronary heart disease  (Chinese Journal of Integrated Traditional Chinese and Western Medicine 2003, 23, 895-897.), angina pectoris (Chinese Journal of Integrated Traditional Chinese and Western Medicine 1998, 18, 282-284.), myocardial infarction (Chinese Med.J.1992, 105, 11-17.)  ...
Claims
 the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine 
 Login to View More Application Information
 Patent Timeline 
 Login to View More  Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/14A61K31/352A61P9/06A61P9/10A61P9/00
CPCA61K9/0019C07D493/14A61K31/7048A61P9/00A61P9/06A61P9/10
 Inventor 娄红祥高健薛霞
 Owner SHANDONG UNIV
Features
- R&D
 - Intellectual Property
 - Life Sciences
 - Materials
 - Tech Scout
 
Why Patsnap Eureka
- Unparalleled Data Quality
 - Higher Quality Content
 - 60% Fewer Hallucinations
 
Social media
Patsnap Eureka Blog
 Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com



