Amlodipine, aliskiren and pril compound antihypertensive medicament

[0016] Preparation of Aliskiren, Amlodipine and Enalapril Fixed Prescription Tablets

[0017]

[0018]

[0019] The preparation method is

[0020] 1. Pass Aliskiren, Amlodipine, and Enalapril (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them evenly in a mixer.

[0021] 2. Put the starch, powdered sugar and dextrin through a 100-mesh sieve and put them into the mixer once to mix evenly, then add the mixed main ingredients and mix evenly, and add an appropriate amount of 70% ethanol to make a soft material.

[0022] 3. Granulate through a 20-mesh sieve.

[0023] 4. Dry the granules in a fluidized bed.

[0024] 5. The dried granules are sized through a 18-mesh sieve.

[0025] 6. Put the whole granules into the mixer, put in magnesium stearate and mix well.

[0026] 7. Tablet into 1,000,000 pieces.

[0028] Preparation of Aliskiren, Amlodipine and Enalapril Fixed Formula Capsules

[0029]

[0030]

[0031] The preparation method is

[0032] 1. Pass Aliskiren, Amlodipine, and Enalapril (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them evenly in a mixer.

[0033] 2. Put the starch, powdered sugar and dextrin through a 100-mesh sieve and put them into the mixer once to mix evenly, then add the mixed main ingredients and mix evenly, and add an appropriate amount of 70% ethanol to make a soft material.

[0034] 3. Granulate through a 20-mesh sieve.

[0035] 4. Dry the granules in a fluidized bed.

[0036] 5. The dried granules are sized through a 18-mesh sieve.

[0037] 6. Put the prepared granules in the capsule filling machine for capsule preparation

[0038] 7. Make 1,000,000 pieces.

[0040] Preparation of Aliskiren, Amlodipine and Enalapril Fixed Formula Powder

[0041]

[0042] The preparation method is

[0043] 1. Pass Aliskiren, Amlodipine, and Enalapril (hereinafter referred to as main ingredients) respectively through a 100-mesh sieve and mix them evenly in a mixer.

[0044] 2. Make 1,000,000 packs after dividing doses.