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Application of human ribosomal protein L23 label peptide in preparation of anti-cancer medicines

A ribosomal protein, human technology, applied in the field of biomedicine, can solve the problem of no reports, and achieve the effect of easy preparation and growth promotion effect

Active Publication Date: 2013-09-25
CHINA WEST NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] So far, there is no report at home and abroad on the strong growth inhibitory effect of human ribosomal protein L23-tagged polypeptide on human breast cancer cells

Method used

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  • Application of human ribosomal protein L23 label peptide in preparation of anti-cancer medicines
  • Application of human ribosomal protein L23 label peptide in preparation of anti-cancer medicines
  • Application of human ribosomal protein L23 label peptide in preparation of anti-cancer medicines

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Embodiment Construction

[0013] The present invention will be described in detail below in conjunction with specific embodiments.

[0014] 1.1 Materials and methods

[0015] 1.1.1 Materials

[0016] 1.1.1.1 Cell lines: normal human liver cells Chang Liver (Zhang's liver cells), human laryngeal cancer Hep-2 cells, human breast cancer Bcap-37 cells, the above cell lines are all commercialized biological materials.

[0017] 1.1.1.2 Reagents: RPMI1640 powder (purchased from Gibco, USA), fetal bovine serum (purchased from Sijiqing Biological Products Company, China), double antibodies (penicillin, streptomycin, purchased from Gibco).

[0018] 1.1.1.3 Human ribosomal protein L23 tag polypeptide (Ribosomal protein L23 signature), synthesized by Shanghai Qiangyao Biotechnology Co., Ltd. The amino acid sequence of the polypeptide is: KKAYVRLAPD YDALDV, the molecular weight is 1.8368KDa, and the isoelectric point is 6.50.

[0019] 1.1.2 Method

[0020] 1.1.2.1 Cell culture

[0021] Human normal liver cells...

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Abstract

The invention discloses application of human ribosomal protein L23 label peptide to preparation of anti-cancer medicines. The amino acid sequence of the human ribosomal protein L23 label peptide is defined by SEQ ID NO:1. The human ribosomal protein L23 label peptide has time and dose dependence on growth inhibition rate of human breast cancer Bcap-37. The human ribosomal protein L23 label peptide at the concentrations of 0.2, 0.5 and 0.8 ug / ml has a good effect on growth inhibition of the human breast cancer Bcap-37, wherein the growth inhibition ratio of the human ribosomal protein L23 label peptide at the concentration of 0.5 ug / ml on the human breast cancer Bcap-37 is highest and reaches 72.29 percent.

Description

technical field [0001] The invention relates to the application of human ribosomal protein L23 tag polypeptide in the preparation of anticancer drugs, and belongs to the technical field of biomedicine. Background technique [0002] Ribosomes are organelles that catalyze protein synthesis. Mammalian ribosomes are composed of 4 RNAs and about 80 different proteins. The names of ribosomal proteins are related to the size of the protein in the ribosome. The small subunit ribosomal proteins are named S1 to S31, and the large subunit The base ribosomal proteins are named L1 to L44. The RPL23a protein is a component of the 60S ribosomal protein. The ribosomal protein encoded by the RPL23A gene is a component of the 60S subunit. This protein belongs to the L23P family of ribosomal proteins. It exists in the cytoplasm. In recent years, some research results have shown that the RPL23A gene is involved in cell growth and regulation. The cDNA and structural gene of the human ribos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P35/00
Inventor 侯万儒侯怡铃张思兰丁祥苏秀兰孙冰王婷
Owner CHINA WEST NORMAL UNIVERSITY
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