Drug composition containing irbesartan and hydrochlorothiazide

[0018]

[0019] Preparation process: first put hydrochlorothiazide and starch into a mortar, grind and mix uniformly, sequentially add sodium carboxymethyl starch, microcrystalline cellulose and mix well, finally add irbesartan and mix well, use 5% PVP in anhydrous ethanol solution Used as a binder to make wet granules, dried at 40°C, granulated, mixed with magnesium stearate, and pressed into tablets.

[0021]

[0022]

[0023] Preparation Process:

[0024] Pass the irbesartan, hydrochlorothiazide, lactose, microcrystalline cellulose and cross-linked polyvinylpyrrolidone in the prescription through a 100-mesh sieve, mix well, add 10% starch slurry to granulate, dry below 60℃, 18-mesh sieve Whole granules, add the prescribed amount of magnesium stearate, mix well, and compress the tablets.

[0026]

[0027] Preparation Process:

[0028] Pass the irbesartan, hydrochlorothiazide, starch, mannitol and L-HPC in the prescription through a 100-mesh sieve, mix them well, add 10% starch slurry to granulate, dry below 50℃, 18-mesh sieve, and add to the prescription The amount of magnesium stearate is mixed well and compressed into tablets.