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Inhalation analgesic and manufacture method and application thereof

An analgesic and nitrous oxide technology, applied in the direction of non-central analgesics, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problems of no ventilator, addictive adverse reactions, insufficient control of burn pain, etc., and achieve relief Effects on Pain and Anxiety

Active Publication Date: 2013-06-05
李玉香
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The qualitative research on the pain experience of burn patients and the qualitative research on medical staff showed that the influencing factors of poor pain control in burn dressing operation are as follows: ①Opioid analgesics addiction and respiratory Inhibited adverse reactions, as well as the characteristics of safe use that require the cooperation of anesthesiologists, cause medical staff and patients in the burn department in my country to worry and worry about its use; ②The burn department lacks specialized anesthesiologists and ventilators;③ At present, there are no guidelines and rules for the management of burn pain in China, so that the treatment methods of burn doctors for dressing change operation pain are determined by personal experience and preference, resulting in almost zero analgesia for burn operation pain, especially for children and the elderly.
④Burn doctors are busy with their work and change the dressings of patients during surgery intervals, so there is no guarantee that the opioid analgesics will be changed after they take effect (20 minutes)
Previous studies have shown that in some areas of China, burn professionals pay great attention to the life-saving treatment of burn patients and wound treatment, and have advanced international-level burn wound treatment skills, but they do not pay enough attention to burn pain management, resulting in burn pain Insufficient control or even failure to manage burn pain

Method used

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  • Inhalation analgesic and manufacture method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: a kind of inhalation analgesic

[0025] An inhaled analgesic made from nitrous oxide (N 2 O) and oxygen (O 2 ) composed of mixed gas, the concentration of nitrous oxide in it was detected by gas chromatography to be 51% (volume ratio). The inhaled analgesic is prepared by the following method: at a temperature greater than minus 6°C, gaseous oxygen is dissolved in liquid nitrous oxide. It can still maintain a gas state and form O after gasification 2 / N 2 O mixed gas.

[0026] The above mixed gas can be placed in a steel cylinder of 2-40 liters for standby.

Embodiment 2

[0027] Embodiment 2: a kind of inhalation analgesic

[0028] An inhaled analgesic made from nitrous oxide (N 2 O) and oxygen (O 2 ) composed of mixed gas, the concentration of nitrous oxide in it was detected by gas chromatography to be 55% (volume ratio). The inhaled analgesic is prepared by the following method: at a temperature greater than minus 6°C, gaseous oxygen is dissolved in liquid nitrous oxide. It can still maintain a gas state and form O after gasification 2 / N 2 O mixed gas.

[0029] The above mixed gas can be placed in a steel cylinder of 2-40 liters for standby.

Embodiment 3

[0030] Embodiment 3: a kind of inhalation analgesic

[0031] An inhaled analgesic made from nitrous oxide (N 2 O) and oxygen (O 2 ) composed of mixed gas, the concentration of nitrous oxide in it is 60% (volume ratio) detected by gas chromatograph. The inhaled analgesic is prepared by the following method: at a temperature greater than minus 6°C, gaseous oxygen is dissolved in liquid nitrous oxide. It can still maintain a gas state and form O after gasification 2 / N 2 O mixed gas.

[0032] The above mixed gas can be placed in a steel cylinder of 2-40 liters for standby.

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Abstract

The invention relates to the pharmacy field, in particular to powerful inhalation analgesic which is efficient, safe and convenient. A patient with burns has to suffer from burnt surface background pain, operation pain and breakthrough pain. Analgesic in European countries, America and other developed countries accounts for almost half of burn treatment western medicine expenses. But opiates and morphine analgesia medicines have defects, and accordingly medical staff and patients in a burn department urgently need to seek for the analgesia medicines which are used for acute pain, and are capable of instantly performing analgesia functions, safe, efficient, easy, convenient, and economical. The invention provides the inhalation analgesic which is a mixed gas composed of nitrous oxide (N2O) and oxygen (O2). The concentration ranges from 51% to 80%, and the inhalation analgesic can be placed in a steel cylinder of 2-40 litres for use. The invention further provides application of the inhalation analgesic in preparing early analgesia medicines and quick-acting analgesia medicines for war wounds, burns, pre-hospital care, transportation and hospital admission.

Description

technical field [0001] The present invention relates to the field of pharmacy, in particular to a quick-acting, safe and convenient powerful inhaled analgesic, a preparation method thereof, and early analgesia and required analgesia for war wounds, burn wounds, pre-hospital first aid, transfer, and hospitalization. Applications in invasive medical procedures with shorter pain duration. Background technique [0002] At the 2010 Monterey World Pain Conference, pain researchers and practitioners from more than 130 countries reached an agreement and adopted the Monterey Declaration, which re-examined Article 5 of the 1948 United Nations Uniform Act of Human Rights: Everyone has immunity The right to be treated for pain...and willfully ignoring a patient's need for pain relief or failing to seek timely professional help when one is unable to provide effective pain relief to the patient is a violation of Title V of the Act. Internationally, pain has been listed as the fifth vital...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/72A61P25/04A61P29/02
Inventor 李玉香余建强常冠青戴秀英余彦昊郭瑶
Owner 李玉香
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