Strychnine-hydroxypropyl-beta-cyclodextrin liposome, preparation method and applications thereof

[0024] The formula of the strychnine-hydroxypropyl-β-cyclodextrin liposome of the present embodiment contains by weight ratio: 1.5 parts of strychnine, 2 parts of HP-β-cyclodextrin, 20 parts of soybean lecithin , Cholesterol 5 parts.

[0025] The preparation method of the strychnine-HP-β-CD inclusion complex liposome of the present embodiment comprises the following steps:

[0026] (1) Preparation of strychnine-HP-β-CD inclusion compound: Weigh 2 parts of HP-β-CD and dissolve them in distilled water to obtain solution IV; mix 1 part of strychnine with a mass ratio of 1:1 dissolved in absolute ethanol to obtain solution V; under constant stirring by a magnetic stirrer, solution V was added dropwise to solution IV, and clathration was performed in a constant temperature water bath at 60°C, and stirring was continued for 2 hours after the dropwise addition to fully clad After combining, refrigerate and pre-freeze, and freeze-dry in a freeze dryer to obtain a white powder strychn...

[0035] The formula of the strychnine-hydroxypropyl-β-cyclodextrin liposome of this embodiment contains by weight ratio: 3 parts of strychnine, 4 parts of HP-β-cyclodextrin, 80 parts of soybean lecithin , Cholesterol 10 parts.

[0036] The preparation method of the strychnine-HP-β-CD inclusion complex liposome of the present embodiment comprises the following steps:

[0037](1) Preparation of strychnine-HP-β-CD inclusion compound: Weigh 4 parts of HP-β-CD and dissolve in distilled water to obtain solution IV; 1 part of strychnine with a mass ratio of 1:1 dissolved in absolute ethanol to obtain solution V; under constant stirring by a magnetic stirrer, solution V was added dropwise to solution IV, and clathration was performed in a constant temperature water bath at 70°C, and stirring was continued for 2 hours after the dropwise addition to fully clad After combining, refrigerate and pre-freeze, and freeze-dry in a freeze dryer to obtain a white powder strychnine-HP-β-CD inclus...

[0045] The formula of the strychnine-hydroxypropyl-β-cyclodextrin liposome of the present embodiment contains by weight ratio: 4 parts of strychnine, 15 parts of HP-β-cyclodextrin, 180 parts of soybean lecithin 20 servings of cholesterol.

[0046] The preparation method of the strychnine-HP-β-CD inclusion complex liposome of the present embodiment comprises the following steps:

[0047] (1) Preparation of strychnine-HP-β-CD inclusion compound: Weigh 15 parts of HP-β-CD and dissolve them in distilled water to obtain solution IV; mix 3 parts of strychnine with a mass ratio of 1:1 dissolved in absolute ethanol to obtain solution V; under constant stirring by a magnetic stirrer, solution V was added dropwise to solution IV, and clathration was performed in a constant temperature water bath at 70°C, and stirring was continued for 2 hours after the dropwise addition to fully clad After combining, refrigerate and pre-freeze, and freeze-dry in a freeze dryer to obtain a white powder ...