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Famciclovir capsule preparation and preparation method thereof

A technology of famciclovir and Lowe capsules, which is applied in the field of medicine, can solve the problems of large amount of sustained-release materials, poor release consistency, and many types of excipients, and achieve zero-order drug release, low production costs, and fewer types of excipients.

Active Publication Date: 2013-09-18
广东彼迪药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patented processes are for the preparation of pellets or small pellets for coating, and the amount and variety of excipients are large, and the production process is complicated, which is not conducive to industrialization
CN102028666A discloses a sustained-release tablet containing famciclovir, wherein famciclovir: sustained-release material: common auxiliary material is 1:0.2-20:10-200, and the sustained-release material is acrylic resin and cellulose, because it adopts ordinary wet granulation, so The amount of sustained-release materials is large; and compared with sustained-release pellets, sustained-release tablets have poor release consistency, which is likely to cause drug burst or uneven release
[0004] In summary, the existing technologies for preparing famciclovir capsules are to control the release rate by coating after preparing pellets. Since it is difficult to form pills with a single drug, it is necessary to add a large amount of microcrystalline cellulose and other excipients, and use techniques such as extrusion and spheronization to prepare the capsules. Small pills, or medicine in the center of blank pills, resulting in many types of excipients and large dosage, which is not conducive to reducing production costs

Method used

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  • Famciclovir capsule preparation and preparation method thereof
  • Famciclovir capsule preparation and preparation method thereof
  • Famciclovir capsule preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] Preparation Process:

[0021] Prescription quantity Weigh famciclovir, ethyl cellulose and high-substituted hydroxypropyl cellulose, add to ethanol, stir to dissolve, add to liquid paraffin containing 0.5% (v / v) Span 80 under stirring conditions, and gradually heat up to 40°C, heat-preserved and stirred for 6 hours, heated to 70°C, stirred for 1 hour, and filtered under reduced pressure to obtain famciclovir sustained-release pellets, which were filled into capsule shells.

Embodiment 2

[0023]

[0024] Preparation Process:

[0025] Prescription quantity Weigh famciclovir, ethyl cellulose and high-substituted hydroxypropyl cellulose, add to ethanol, stir to dissolve, add to liquid paraffin containing 2% (v / v) Span 80 under stirring conditions, and gradually heat up to 40°C, heat-preserved and stirred for 6 hours, heated to 70°C, stirred for 1 hour, and filtered under reduced pressure to obtain famciclovir sustained-release pellets, which were filled into capsule shells.

Embodiment 3

[0027]

[0028] Preparation Process:

[0029] Prescription quantity Weigh famciclovir, ethyl cellulose and high-substituted hydroxypropyl cellulose, add to ethanol, stir to dissolve, add to liquid paraffin containing 0.5% (v / v) Span 80 under stirring conditions, and gradually heat up to 40°C, heat-preserved and stirred for 6 hours, heated to 70°C, stirred for 1 hour, and filtered under reduced pressure to obtain famciclovir sustained-release pellets, which were filled into capsule shells.

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PUM

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Abstract

The invention discloses a famciclovir capsule preparation which comprises a capsule shell and a content, wherein the content consists of famciclovir sustained-release pellets; the famciclovir sustained-release pellets are prepared through the following steps of: dissolving famciclovir, ethyecellulose and high-substituted hydroxy propyl cellulose in ethanol, adding the components into liquid wax with a surfactant under the stirring condition, gradually raising the temperature to be 38-40 DEG C, reserving the temperature and stirring for 4-8 hours, raising the temperature to be 68-72 DEG C, stirring for 0.5-2 hours, reducing the pressure and filtering so as to obtain the famciclovir sustained-release pellets. By utilizing the preparation disclosed by the invention, not only can the amount of sustained-release material be greatly reduced, but also the phenomenon of burst release of the medicine is eliminated.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antiviral drug preparation, in particular to a famciclovir capsule preparation and a preparation method thereof. Background technique [0002] Famciclovir (famcictovir, FCV) is a second-generation ring-opening nucleoside antiviral drug, it is a prodrug developed to improve the bioavailability of penciclovir (penciclovir, PCV). The base-6-deoxy analogue, which is rapidly deacetylated and oxidized to equimolecular penciclovir after being absorbed by the intestinal wall after oral administration, is widely used clinically to treat herpes zoster and genital herpes. Famciclovir tablets are taken 3 times a day, 250-500 mg each time, and there are adverse reactions such as vomiting, headache, and fever. In order to reduce the number of medications, improve the dependence of patients on medication, and reduce the occurrence of adverse reactions, famciclovir sustained-rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61K31/52A61P31/22A61P15/00A61P17/00
Inventor 朱富根刘小兰杨业东
Owner 广东彼迪药业有限公司
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