Application of milrinone in preparation of medicine for treating diabetic foot ulcer

[0023] The selection of embodiment 1 research object

[0024] Inclusion criteria: patients with type 1 or type 2 diabetes, meeting the WHO definition of diabetic foot disease, that is, diabetic patients with lower extremity infection, ulceration and / or destruction of deep tissues due to neuropathy and various degrees of peripheral vascular disease ; DFU patients with Wagner grade 1-5; meet the Framingham diagnostic criteria for heart failure, and NYHA grade Ⅱ-Ⅲ; blood pressure ≥ 90 / 60mmHg.

[0025] The severity of DFD is graded using the Wagner grading method, and the specific grades are as follows: grade 0, skin intact (before ulceration), with peripheral vascular disease and high-risk signs of the foot; grade 1, skin surface ulcers, subcutaneous Within the fat layer; Grade 2, ulcer depth reaches tendons or ligaments; Grade 3, osteomyelitis or extensive infection of deep tissues; Grade 4, gangrene of the toes or front of the foot; Grade 5, gangrene of the entire or involving ...

[0036] Embodiment 2 Administration

[0037] Using a randomized, controlled, single-blind method, the DFU patients included in the study were randomly divided into an intensive treatment group and a conventional treatment group according to different treatment schemes. A total of 142 patients with DFU combined with heart failure were included in the study, including 67 cases in the intensive treatment group, 65 cases were completed, 1 case was lost to follow-up, and 1 case was withdrawn from the study due to drug intolerance; 75 cases were in the conventional treatment group, 72 cases were completed, and 3 cases were lost to follow-up. example. There was no significant difference in the number of cases lost to follow-up between the two groups (P>0.05).

[0038] Conventional treatment group: conventional treatment, that is, according to the guidelines for the diagnosis and treatment of heart failure proposed by AHA, losartan potassium (50 mg, orally, once a day) was given to di...

[0044] There are 3 time nodes in the study: baseline period, 2 weeks and 3 months of treatment.

[0045] Statistical methods: Statistical processing was carried out using the Microsoft Windows version of SAS9.13 statistical software package. The measurement data satisfying the normal distribution is expressed by x±s, the comparison between two groups is performed by t test, and the comparison between multiple groups is performed by analysis of variance, while the measurement data of non-normal distribution is expressed by M(P25, P75), and logarithmic transformation is used Then compare between groups. The count data are expressed as ratios, and the four tables and the x of R×C are used 2 The test was compared with Fisher's exact test. All tests were two-sided, and P<0.05 was defined as statistically significant.

[0046] By monitoring the changes of ankle-brachial index (ABI) in patients with foot ulcers before and after treatment, it was observed whether the intensive trea...