Manufacturing method of temperature-sensitive hydrogel compound coating intravascular stent

[0023] (1): The bare metal vascular stent was ultrasonically cleaned in acetone, absolute ethanol and deionized water for 30 minutes respectively to remove surface residues, and vacuum dried for 30 minutes; then the bare metal vascular stent was placed in 5 M NaOH solution for 60 minutes. Soak at ℃ for 24 h, take it out, rinse it with double distilled water for more than 3 times, put it into double distilled water for ultrasonic cleaning for 30 min, and vacuum dry for 30 min.

[0024] (2): Dip the bare metal stent obtained in (1) into the rapamycin drug solution, and the drug coating amount is 50 μg / cm 2 , placed at room temperature for 30 minutes, and vacuum-dried for 30 minutes to obtain a drug-coated metal vascular stent.

[0025] (3): Immerse the metal vascular stent obtained in (2) in 0.1% (W / V) hydroxybutyl chitosan aqueous solution (the gelation temperature of hydroxybutyl chitosan is 15°C, and the degree of substitution of hydroxybutyl chitosan is 2.0), placed at room...

[0028] (1): The bare metal vascular stent was ultrasonically cleaned in acetone, absolute ethanol and deionized water for 60 minutes respectively to remove surface residues, and then vacuum dried for 30 minutes; then the bare metal vascular stent was placed in 3M NaOH solution at 70 °C Soak for 48 hours, take it out, rinse with double distilled water for more than 3 times, put it into double distilled water for ultrasonic cleaning for 60 minutes, and vacuum dry for 30 minutes.

[0029] (2): Immerse the metal vascular stent obtained in (1) in the paclitaxel drug solution, and the drug coating amount is 150 μg / cm 2 , placed at room temperature for 60 minutes, and vacuum-dried for 30 minutes to obtain a drug-coated metal vascular stent.

[0030] (3): Immerse the drug-coated metal vascular stent obtained in (2) in 1% (W / V) hydroxybutyl chitosan aqueous solution (the gelation temperature of hydroxybutyl chitosan is 30°C, hydroxybutyl chitosan The degree of substitution is 0.5), pl...

[0033] (1): First, the bare metal stent was ultrasonically cleaned in acetone, absolute ethanol, and deionized water for 40 minutes to remove surface residues, and vacuum dried for 30 minutes; then the bare metal stent was placed in 3.5M NaOH solution, Soak at 40 °C for 72 h, take it out, rinse with double distilled water for more than 3 times, put it into double distilled water for ultrasonic cleaning for 40 min, and vacuum dry for 30 min.

[0034] (2): The metal stent obtained in (1) was immersed in the rapamycin drug solution, and the drug coating amount was 150 μg / cm 2 , placed at room temperature for 50 minutes, and vacuum-dried for 30 minutes to obtain a drug-coated metal vascular stent.

[0035] (3): Immerse the drug-coated metal stent obtained in (2) in 0.3% (W / V) aqueous solution of hydroxybutyl chitosan (the gelation temperature of hydroxybutyl chitosan is 21°C, hydroxybutyl chitosan The degree of substitution is 1.1), placed at room temperature for 40 min, dried in...