Solid-phase synthesis of goserelin

The invention discloses a solid-phase synthesis method of goserelin, comprising: adopting HBTU / DIPEA as a condensation system, sequentially coupling Fmoc-Ser-OH, Fmoc-Trp-OH; Double the corresponding volume to remove the carrier 2-CTC Resin in the intermediate product, but keep all the side chain protecting groups; adjust the fully protected lysate to be slightly alkaline with DIPEA (N,N-diisopropylethylamine) Add semicarbazide hydrochloride and PyBop (1H-benzotriazole-1-yloxytripyrrolidinyl hexafluorophosphate [coupling agent for peptides) to the fully protected lysate for reaction coupling to obtain the retained side Goserelin peptide solution with chain protecting group; add 20% TFA / DCM lysate into frozen diethyl ether to settle to obtain white solid crude peptide; vacuum dry the white solid crude peptide and dissolve it in methanol, add ammonium formate and Pa / c carry out hydrogenation reaction to remove the side chain protecting group in the peptide sequence. The invention avoids many side reactions, improves the purity of the target peptide, and has a relatively high yield. The operation is convenient and feasible, and the intermediate can be tracked and controlled, and the whole process is beneficial to scale-up production.