Methylnaltrexone bromide solid composition and preparation method thereof

[0052] Embodiment 1 prepares methylnaltrexone bromide sheet

[0053]

[0054] Adhesive is formulated into the concentration of 6%, and prescription quantity tartaric acid is dissolved in binder solution, and prescription quantity methylnaltrexone bromide is dissolved in above-mentioned solution; All the other auxiliary materials pass through 80 mesh sieves, mannitol and cross-linked carboxymethyl cellulose Mix plain sodium evenly; add the binder to the above-mentioned mixed powder to make soft material, pass through a 24-mesh sieve to granulate; dry until the water content is 1.34%, mix the above-mentioned granules with magnesium stearate evenly, and then press the tablet machine, No. 6 Punch, pressure 54N.

[0055] Embodiment 2 prepares methylnaltrexone bromide sheet

[0056]

[0057] Adhesive is prepared into the concentration of 8%, the prescription quantity of citric acid is dissolved in the binder solution, and the prescription quantity of methylnaltrexone is dissolved in the above solution; the rest of the auxiliary materials are passed through 80 mesh sieves, precrosslinked starch and crosslinked Mix povidone evenly; add the binder to the above-mentioned mixed powder to make soft material, pass through a 24-mesh sieve to granulate; dry until the water content is 2.05%, mix the above-mentioned granules with sodium lauryl sulfate evenly, and press the tablet machine , No. 6.5 punch, pressure 50N.

[0058] Embodiment 3 prepares methylnaltrexone bromide sheet

[0059]

[0060] The adhesive is prepared into a concentration of 5%, the prescription amount of L-aspartic acid is dissolved in the adhesive solution, and the prescription amount of bromidenaltrexone is dissolved in the above solution; the remaining auxiliary materials are passed through a 60-mesh sieve, lactose and hydroxyl Mix propylmethyl cellulose evenly; add the binder to the above-mentioned mixed powder to make a soft material, pass through a 20-mesh sieve to granulate; dry until the water content is 2.17%, mix the above-mentioned granules with talcum powder evenly, and then press the tablet machine, No. 5.5 Punch, pressure 62N.