Oral aripiprazole liquid dry suspension agent and preparation method thereof
A technology of aripiprazole and dry suspension, which is applied in the field of medicine and can solve the problems of harm to patients, inconvenient administration, poor stability, etc.
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Embodiment 1
[0013]
[0014] Preparation Process:
[0015] 1) Grinding the aripiprazole, sucrose and xylitol through a 100-mesh sieve for later use;
[0016] 2) Mix the aripiprazole, the above-mentioned sucrose, xylitol, and xanthan gum evenly, add a binder, stir and granulate, dry at 50°C, granulate, and classify to obtain granules for later use;
[0017] 3) Mix the flavoring agent, sodium carboxymethyl starch and the granules prepared in the above 2).
Embodiment 2
[0019]
[0020] Preparation Process:
[0021] 1) Pass the aripiprazole, mannitol, and xylitol through a 100-mesh sieve for later use;
[0022] 2) Mix the aripiprazole with the above-mentioned mannitol, xylitol, and xanthan gum evenly, add a binder, stir and granulate, dry at 50°C, granulate, and classify to obtain granules for later use;
[0023] 3) Mix sucralose, strawberry essence, sodium carboxymethyl starch and the granules prepared in the above 2).
Embodiment 3
[0025]
[0026] Preparation Process:
[0027] 1) Pass the aripiprazole, lactose, and xylitol through a 100-mesh sieve for later use;
[0028] 2) Mix the aripiprazole with the above-mentioned lactose, xylitol, and xanthan gum evenly, then add a binder, stir and granulate, dry at 50°C, granulate, and classify to obtain granules for later use;
[0029] 3) Mix sucralose, orange essence, sodium carboxymethyl starch and the granules prepared in 2) above to get the product.
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