A dendrified bactericidal microsphere and its preparation method and application

[0045] In this embodiment, the dendritic bactericidal microspheres are prepared according to the following method:

[0046] (1) Synthesis of G0.5: Weigh 15 mg of chlorine balls and place them in a 100 mL three-neck flask, add 25 mL of reaction solvent DMF, soak for 12 hours to fully swell the carrier. Add ethylenediamine and 2.25g catalyst metal sodium in the three-necked bottle then, the mol ratio of chlorine ball and ethylenediamine is 1:3, feeds N 2 protection, stirring the reaction at 90°C for 10h, and filtering off the reacted G0.5. Rinse three times with the reaction solvent DMF, and soak in 1mol / L NaOH for 8 hours. Then rinse with absolute ethanol, acetone, and ether repeatedly for 3 times, and put it into a 50°C vacuum drying oven to dry for later use;

[0047] (2) Synthesis of G1.0: Weigh 15 mg of G0.5 with the largest grafting amount and place it in a 100 mL three-neck flask, add 25 mL of reaction solvent methanol to soak for 12 hours, add methyl acrylate dropwise ...

[0054] In this embodiment, the dendritic bactericidal microspheres are prepared according to the following method:

[0055] (1) Synthesis of G0.5: Weigh 15 mg of chlorine balls and place them in a 100 mL three-neck flask, add 25 mL of reaction solvent DMF, soak for 12 hours to fully swell the carrier. Add ethylenediamine and 2.25g catalyst metal sodium in the three-necked bottle then, the mol ratio of chlorine ball and ethylenediamine is 1:4, feeds N 2 Protected, stirred and reacted at 100°C for 11h, and the reacted G0.5 was filtered off. Rinse three times with the reaction solvent DMF, and soak in 1mol / L NaOH for 8 hours. Then rinse with absolute ethanol, acetone, and ether repeatedly for 3 times, and put it into a 50°C vacuum drying oven to dry for later use;

[0056] (2) Synthesis of G1.0: Weigh 15 mg of G0.5 with the largest grafting amount and place it in a 100 mL three-neck flask, add 25 mL of reaction solvent methanol to soak for 12 hours, add methyl acrylate dropwise...

[0063] In this embodiment, the dendritic bactericidal microspheres are prepared according to the following method:

[0064] (1) Synthesis of G0.5: Weigh 15 mg of chlorine balls and place them in a 100 mL three-neck flask, add 25 mL of reaction solvent DMF, soak for 12 hours to fully swell the carrier. Add ethylenediamine and 2.25g catalyst metal sodium in the three-necked bottle then, the mol ratio of chlorine ball and ethylenediamine is 1:5, feeds N 2protection, stirring the reaction at 110°C for 12h, and filtering off the reacted G0.5. Rinse three times with the reaction solvent DMF, and soak in 1mol / L NaOH for 8 hours. Then rinse with absolute ethanol, acetone, and ether repeatedly for 3 times, and put it into a 50°C vacuum drying oven to dry for later use;

[0065] (2) Synthesis of G1.0: Weigh 15 mg of G0.5 with the largest grafting amount and place it in a 100 mL three-neck flask, add 25 mL of reaction solvent methanol to soak for 12 hours, add methyl acrylate dropwise ...