Retinoic acid compound, and preparation method, intermediate and application thereof

A kind of retinoic acid compound, its preparation method, intermediate and application technical field The invention relates to a retinoic acid compound, its preparation method, intermediate and application. Background technique Tazarotene is a retinol drug with RAR subtype selectivity (J Am AcadDermatol.1997, 37, S12.), mainly used for local epithelial hyperplasia (psoriasis, psoriasis, acne etc.) treatment. Tazarotene exists as a prodrug of the ethyl ester. The drug enters the body and undergoes enzymatic metabolism to obtain the carboxyl-type active metabolite Tazarotenic acid, which can highly selectively interact with RARβ and RARγ receptors, and also has a certain effect on RARβ, but has a weak effect on RXR. Contents of the invention The problem to be solved by the present invention is to provide a kind of retinoic acid compound, its preparation method, intermediate and application in order to overcome the defects such as tazarotene’s poor tumor cell inhibitory...