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Application of emricasan in preparation of medicine for treating ischemia/reperfusion injury

A technology for reperfusion injury and ischemic stroke, which is applied in the field of biomedicine and can solve problems such as the absence of Enlika

Active Publication Date: 2018-02-02
湖南恒兴医药科技有限公司
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AI Technical Summary

Problems solved by technology

[0005] The caspase inhibitor Enlikagen can specifically inhibit caspase-3 / 7, but there is no report on the treatment of ischemic stroke, especially for reducing ischemia / reperfusion injury

Method used

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  • Application of emricasan in preparation of medicine for treating ischemia/reperfusion injury
  • Application of emricasan in preparation of medicine for treating ischemia/reperfusion injury
  • Application of emricasan in preparation of medicine for treating ischemia/reperfusion injury

Examples

Experimental program
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Embodiment Construction

[0015] Animal experiment: the protective effect of Enlikagen on rat model of ischemic stroke.

[0016] Implemented drugs: sodium carboxymethylcellulose (CMC-Na) was purchased from Shanghai Shanpu Chemical Co., Ltd.

[0017] Suspension was made of Enlicaxan using 0.5% sodium carboxymethylcellulose (CMC-Na) as a vehicle.

[0018] Experimental animals: 48 healthy male SD rats with a body weight of 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative amounts, and then administered orally according to the requirements of each group in the experiment.

[0019] Establishment method of ischemic stroke: rat cerebral ischemia / reperfusion model was prepared by middle cerebral artery occlusion (MCAO) method. The steps are as follows: (1) Separate the external carotid artery (CCA), and separate the right external carotid artery (ECA) and internal ca...

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Abstract

The invention discloses application of emricasan in the preparation of a medicine for treating ischemia / reperfusion injury. By using emricasan in treatment of ischemia / reperfusion injury, especially treatment of brain tissue neuropathy and even especially protective effect of cerebral ischemia / reperfusion (cerebral arterial thrombosis), cerebral ischemia / reperfusion injury can be remarkably mitigated.

Description

technical field [0001] The invention belongs to the field of biomedicine. The present invention provides new uses and administration methods of Emricasan, including the protective effect on cerebral ischemia / reperfusion (ischemic stroke), reducing ischemia / reperfusion injury, and expanding the scope of Emricasan. The range of card health indications. Background technique [0002] Ischemic stroke is a common and frequently-occurring disease that seriously endangers human health. It has become the first cause of disability and the third cause of death in the world. The incidence of ischemic stroke accounts for about 70-80% of cerebrovascular diseases. [0003] Ischemic stroke involves multiple mechanisms such as calcium overload, excitatory amino acid toxicity, and oxidative stress, and these mechanisms intersect to eventually cause neuronal cell death. Apoptosis is one of the main ways of neuronal cell death in ischemic stroke. Apoptosis mainly includes intrinsic apoptotic...

Claims

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Application Information

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IPC IPC(8): A61K31/197A61P9/10A61P25/00
CPCA61K31/197
Inventor 罗秀菊彭军田静刘斌任凯迪彭靖杰李嘉辉付四海
Owner 湖南恒兴医药科技有限公司
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