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Application of ponatinib in preparation of medicine for treating ischemia/reperfusion injury

A technology for reperfusion injury and ischemic stroke, which is applied in the field of biomedicine and can solve problems such as lack of ponatinib

Active Publication Date: 2020-04-03
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the treatment of ischemic stroke with ponatinib

Method used

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  • Application of ponatinib in preparation of medicine for treating ischemia/reperfusion injury
  • Application of ponatinib in preparation of medicine for treating ischemia/reperfusion injury
  • Application of ponatinib in preparation of medicine for treating ischemia/reperfusion injury

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] Animal experiment: the protective effect of ponatinib on ischemic stroke

[0016] Implemented drugs: sodium carboxymethylcellulose (CMC-Na) was purchased from Shanghai Shanpu Chemical Co., Ltd.

[0017] Ponatinib was made into a suspension using 0.5% carboxymethylcellulose sodium (CMC-Na) as a vehicle.

[0018] Experimental animals: 48 healthy male SD rats with a body weight of 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative amounts, and then administered orally according to the requirements of each group in the experiment.

[0019] Modeling method: The rat model of cerebral ischemia / reperfusion injury was prepared by the middle cerebral artery occlusion (MCAO) method. The steps are as follows: (1) Separate the external carotid artery (CCA), and separate the right external carotid artery (ECA) and internal carotid artery (IC...

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Abstract

The invention discloses application of ponatinib in the preparation of a medicine for treating ischemia / reperfusion injury. By using ponatinib in treating ischemia / reperfusion injury, especially in treating brain tissue neuropathy and even especially in the protective effect on ischemic cerebral apoplexy, cerebral ischemia / reperfusion injury can be remarkably mitigated.

Description

technical field [0001] The invention belongs to the field of biomedicine, and the invention provides a new use and administration mode of the tyrosine kinase inhibitor ponatinib (Ponatinib), including the protective effect on cerebral ischemia / reperfusion (ischemic stroke) , expanding the scope of Ponatinib indications. Background technique [0002] Ischemic stroke is a common and frequently-occurring disease that seriously endangers human health. It has become the first cause of disability and the third cause of death in the world. The incidence of ischemic stroke accounts for about 70-80% of cerebrovascular diseases. [0003] Cerebral ischemic injury is related to multiple mechanisms such as excessive formation of free radicals, excitatory amino acid toxicity, intracellular calcium overload, and inflammatory response. Regardless of the mechanism, the final outcome will lead to neuronal cell death, functional destruction, and cerebral infarction form. There are two main w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5025A61P9/10A61P13/12A61P1/16
CPCA61K31/5025
Inventor 罗秀菊彭军田静佘浪刘斌彭靖杰李嘉辉许锦云付四海
Owner CENT SOUTH UNIV
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