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Niclosamide and applicaiton of niclosamide derivatives

A technology of niclosamide and its derivatives, which is applied in the field of pharmaceutical application and can solve the problems that niclosamide has not been further reported

Inactive Publication Date: 2018-04-24
CHANG GUNG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, niclosamide has not been further reported for use in other indications

Method used

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  • Niclosamide and applicaiton of niclosamide derivatives
  • Niclosamide and applicaiton of niclosamide derivatives
  • Niclosamide and applicaiton of niclosamide derivatives

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Embodiment Construction

[0025] At least one embodiment of the present invention relates to the use of Niclosamide and Niclosamide derivatives. The niclosamide derivatives include modified niclosamide and salts thereof; more specifically, the niclosamide derivatives are compounds with the following general formula:

[0026]

[0027] Among them, R stands for NO 2 , Cl or CF 3 .

[0028] The compound niclosamide (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide) used in some examples has the following chemical formula:

[0029]

[0030] The compound BPR1H366 (5-chloro-N-(2,4-dichloro)-2-hydroxybenzamide) used in some examples has the following chemical formula:

[0031]

[0032] The compound BPR1H369 (5-chloro-N-(2-chloro-4-trifluoromethyl)-2-hydroxybenzamide) used in some examples has the following chemical formula:

[0033]

[0034] At least one embodiment of the present invention is the use of niclosamide and its derivatives, which are used to prepare drugs for inhibiting platel...

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PUM

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Abstract

The invention discloses niclosamide and an application of niclosamide derivatives. The niclosamide and niclosamide derivatives are used for the manufacture of medicaments for suppressing platelet aggregation or preventing thrombosis-related diseases. The niclosamide and niclosamide derivatives in the medicaments inhibit the production of thromboxane A2, therefore suppress platelet aggregation andprevent thrombosis-related diseases.

Description

technical field [0001] The invention relates to the field of pharmaceutical application, in particular to the application of niclosamide and its derivatives. Background technique [0002] Niclosamide (2',5-dichloro-4'-nitrosalicylanilide), also known as Niclosamide, has been widely used since 1960 to treat pork tapeworm (Taenia solium), beef tapeworm (Taenia saginata ), Taeniasis caused by Diphyllobothriasis latum and Hymenolepis nana. Common drugs containing niclosamide include Yomesan, Copharten and Kontal, and their indications include the treatment of tapeworm and roundworm infections. When niclosamide is used to treat tapeworm infection, it is generally recommended that adults take 2 grams of niclosamide tablets orally daily for seven to fourteen consecutive days; because niclosamide can inhibit the oxidation of the mitochondria of intestinal tapeworms Phosphorylation (oxidative phosphorylation), so it can kill tapeworms by preventing tapeworms from taking up glucose....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/609A61P7/02A61P9/00A61P9/10A61P11/00A61P13/12
CPCA61K31/609A61K38/01A61K31/122A61K31/167A61K38/39A61P11/00A61P13/12A61P7/02A61P9/00A61P9/10A61K2300/00
Inventor 张国友曾庆平
Owner CHANG GUNG UNIVERSITY
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