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Effect of curculigoside in promoting ischemic super-long random skin flap survival

A curculin, super-long technology, applied in the field of curculin in promoting the survival of ischemic super-long random skin flap

Active Publication Date: 2018-07-24
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Description
  • Claims
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Problems solved by technology

[0003] Curculigo curculigo is one of the important traditional Chinese medicines. It is widely distributed in my country. As a tonic, Curculigoside A can warm the kidneys and strengthen the yang, and dispel cold and damp. Loosening, anti-oxidation, improving the cognitive ability of aged animals, protecting nerves, etc.; but there is no relevant report on the effect of curculigoside on the survival of skin flaps

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  • Effect of curculigoside in promoting ischemic super-long random skin flap survival
  • Effect of curculigoside in promoting ischemic super-long random skin flap survival
  • Effect of curculigoside in promoting ischemic super-long random skin flap survival

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Embodiment Construction

[0014] Curculigoside can significantly improve the survival of ischemic ultra-long random flap. In the process of promoting the survival of ischemic ultra-long random flaps, the method of intragastric administration was adopted. Dissolve 1 mg of curculigoside powder in 1 ml of normal saline to make a 1 mg / ml solution. The dosage is 10 mg of curculigoside per kilogram of rats per day, 5 to 7 days as a course of treatment. The following is the evaluation of the role of curculigoside in promoting the survival of random ischemic flaps:

[0015] 1. Establishment of random flap model of ischemia

[0016] Sixty healthy male SD rats were selected, provided by the Experimental Animal Center of Wenzhou Medical University, clean grade, SYXK [Zhe] 2015-0009, weighing 250-300g and aged. The rats were divided into a curculigoside experimental group and a normal saline control group according to the random number table method, with 30 rats in each group. Using the modified McFarlane flap ...

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Abstract

The invention relates to the effect of curculigoside in promoting ischemic random skin flap survival. An oral administration way is adopted in the process of promoting ischemic random skin flap survival, according to the use method, the daily oral dose is 10mg / kg, and 5-7d is a course of treatment. A large number of animal experiments conclude that the use of curculigoside can obviously increase the survival area ratio of skin flap, and can well promote random ischemic skin flap survival.

Description

technical field [0001] The invention relates to a new application of curculigoside, in particular to the function of curculigoside in promoting the survival of ischemic ultra-long random skin flap. Background technique [0002] In recent years, there have been more and more patients with high-energy injuries such as car accident injuries, high-fall injuries, and heavy object injuries. High-energy injuries cause severe skin and soft tissue damage. After debridement, skin and soft tissue defects often occur, making it impossible to perform direct surgery. suture. Flap coverage is required, and random flaps are widely used in wound repair because of their flexible application, short learning period, and good appearance recovery. However, when the length-to-width ratio of random flaps exceeds 1.5:1, varying degrees of necrosis often occur at the distal end of the flap. This undoubtedly limits the clinical application of random flaps, so how to increase the survival of random f...

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Application Information

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IPC IPC(8): A61K31/7034A61P9/10
CPCA61K31/7034
Inventor 林丁盛陈庭祥李志杰高伟阳
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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