Compound multi-component injection

[0191] The preparation of embodiment 1 compound multi-component injection

[0192]

[0193] Preparation Process:

[0194] Step 1: Take 80% of the prescription amount of water for injection, add polysorbate 80, ascorbic acid in sequence, stir, and dissolve;

[0195] Step 2: Take the prescribed amount of Danshensu, Ligustrazine, Paeoniflorin, and Hydroxysafflower Yellow A in the solution obtained in Step 1, stir and dissolve;

[0196] Step 3: Take the prescribed amount of glycerin, add it to the solution obtained in step 2, stir and dissolve;

[0197] Step 4: Add water for injection to the full amount, and adjust the pH value of the solution obtained in step 3 to 5.5-6.0 with 0.1M hydrochloric acid or sodium hydroxide;

[0198] Step 5: Take the medicinal liquid obtained in step 4, add 0.1% activated carbon, let it stand for 30 minutes, absorb endotoxin, and pass through the 0.22um microporous membrane twice to remove the activated carbon;

[0199] Step 6: Take the medicina...

[0201] The preparation of embodiment 2 compound multi-component injection freeze-dried powder

[0202]

[0203] Preparation:

[0204] Step 1: Take 80% of the prescription amount of water for injection, add polysorbate 80, ascorbic acid in sequence, stir, and dissolve;

[0205] Step 2: Take the prescribed amount of Danshensu, Ligustrazine, Paeoniflorin, and Hydroxysafflower Yellow A in the solution obtained in Step 1, stir and dissolve;

[0206] Step 3: Take the prescribed amount of freeze-dried support agent (mannitol, dextran 40 or dextran 60), add it to the solution obtained in step 2, stir and dissolve;

[0207] Step 4: Add water for injection to the full amount, and adjust the pH value of the solution obtained in step 3 to 5.5-6.0 with 0.1M hydrochloric acid or sodium hydroxide;

[0208] Step 5: Take the medicinal liquid obtained in step 4, add 0.1% activated carbon, let it stand for 30 minutes, absorb endotoxin, and pass through the 0.22um microporous membrane twice ...