Method for inducing chronic and acute liver failure mouse model by using carbon tetrachloride

The invention relates to a method for inducing a chronic and acute liver failure mouse model, in particular to a method for inducing the chronic and acute liver failure mouse model by using carbon tetrachloride, which comprises the following steps of: a grouping method is characterized by randomly and averagely dividing Balb / c inbred line mice into a model group and a control group; an administration method is characterized by diluting carbon tetrachloride to concentrations of 10% and 50% by using olive oil, continuously injecting 10% carbon tetrachloride into the abdominal cavity of a mouse in the model group according to 5-8ml / kg body weight, administrating twice a week, and continuously administrating for 8 weeks; after 8 weeks, injecting the 50% carbon tetrachloride into the abdominalcavity once according to 5-8 ml / kg body weight; and a detection method is characterized by performing biochemical index detection and liver pathological examination on the experimental mouse. The method has the beneficial effects that Balb / c inbred line mice are adopted as model animals, most inbred lines can be adopted, the repeatability is better, the cost is lower compared with rats, and the operation is simpler and more convenient. The model better conforms to the disease development process of clinical hepatitis B virus (HBV) related chronic and acute liver failure.