Methods and compositions for controlling cardiac fibrosis and remodeling

technical field [0001] The present invention provides methods and compositions for controlling myocardial fibrosis and cardiac remodeling in a subject by modulating the expression of one or more lncRNAs associated with cardiac-specific super-enhancers (SE). Background technique [0002] Acute myocardial infarction (MI) due to coronary artery disease often results in maladaptive myocardial remodeling and heart failure (HF) (1,2). HF imposes an enormous economic and clinical burden on industrialized countries, and in the United States alone, HF is responsible for more than 400,000 deaths and more than $20 billion in healthcare costs annually (3). Initial translational research has focused on the heart's contractile cells, the cardiomyocytes (CMs), as targets for therapeutic approaches aimed at restoring myocardial function. Despite the widespread belief that acute and chronic injury trigger tissue remodeling, this invariably leads to and ultimately contributes to the developm...