Pharmaceutical composition for removing phlegm and relieving asthma and application of pharmaceutical composition
A composition and drug technology, applied in the field of drug spectrum, can solve the problems of low bioavailability, long dissolution time, affecting drug efficacy, etc.
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Embodiment 1
[0063] This embodiment provides a pharmaceutical composition for eliminating phlegm and relieving asthma: the content of theophylline in its unit preparation is 120 mg, the content of guaifenesin is 100 mg, and its dosage form is syrup.
[0064] Its preparation method is: dissolving theophylline and guaifenesin in appropriate amount of water, heating to 60°C, stirring and dissolving; adding 500mL of sucrose, adding appropriate amount of sodium benzoate and flavoring agent, stirring evenly, and filtering to obtain the product.
Embodiment 2
[0066] This embodiment provides a pharmaceutical composition for eliminating phlegm and relieving asthma, its dosage form is a soft capsule, which includes a drug suspension and rubber;
[0067] Among them, the prescription of drug suspension is:
[0068] Guaifenesin 0.09kg, anhydrous theophylline 0.15kg, water 0.012kg, PEG400 6.38kg;
[0069] The rubber material can be selected according to the prior art.
[0070] Its preparation method is:
[0071] Weigh about 5.75kg of polyethylene glycol 400 and place it in the batching pot, add 0.012kg of purified water, mix well, stir to dissolve completely, heat to 35°C, and keep warm. Weigh 0.09kg of guaifenesin in the prescribed amount, pass through a 40-mesh sieve, add to the above solution under stirring, and fully dissolve to obtain the first solution, and continue to keep warm at 35°C. Weigh 0.15 kg of anhydrous theophylline, pass through a 40-mesh sieve, add to the first solution under stirring, mix well, add 400 to 6.38 kg of...
Embodiment 3
[0074] This embodiment provides a pharmaceutical composition for eliminating phlegm and relieving asthma, its dosage form is a soft capsule, which includes a drug suspension and rubber;
[0075] Among them, the prescription of drug suspension is:
[0076] Guaifenesin 0.09kg, anhydrous theophylline 0.15kg, water 0.036kg, PEG400 6.38kg;
[0077] The rubber material can be selected according to the prior art.
[0078] Its preparation method is:
[0079] Weigh about 6 kg of polyethylene glycol 400 and place it in the batching pot, add 0.036 kg of purified water, mix well, stir to dissolve completely, heat to 35°C, and keep warm. Weigh 0.09 kg of guaifenesin in the prescribed amount, pass through a 40-mesh sieve, add to the above solution under stirring, and fully dissolve to obtain the first solution, and continue to keep warm at 35°C. Weigh 0.15 kg of anhydrous theophylline, pass through a 40-mesh sieve, add to the first solution under stirring, mix well, add 400 to 6.38 kg of...
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