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Physiological poison metabolism kinetic model of rat exposed to 3-MCPD through mouth and construction method of physiological poison metabolism kinetic model

A 3-MCPD, mechanical model technology, applied in medical science, diagnosis, diagnostic recording/measurement, etc., to achieve the effect of broad development prospects

Pending Publication Date: 2022-07-22
ZHEJIANG UNIV
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  • Claims
  • Application Information

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Problems solved by technology

Research on food processing pollution is relatively rare, because there is no PBTK model of 3-MCPD yet

Method used

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  • Physiological poison metabolism kinetic model of rat exposed to 3-MCPD through mouth and construction method of physiological poison metabolism kinetic model
  • Physiological poison metabolism kinetic model of rat exposed to 3-MCPD through mouth and construction method of physiological poison metabolism kinetic model
  • Physiological poison metabolism kinetic model of rat exposed to 3-MCPD through mouth and construction method of physiological poison metabolism kinetic model

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Embodiment 1

[0083] 1. For details on the construction process of the physiological toxicokinetic model of 3-MCPD in rats, see figure 1, the steps are as follows: determine the kinetic process of 3-MCPD absorption, distribution, metabolism and excretion in rats through literature search and data analysis. Specifically, the kinetic process includes: the first step, absorption. The main ways of 3-MCPD absorbed by the body are the digestive system and the respiratory system. In this case, the oral gavage is used. The second step is distribution. After 3-MCPD enters the human body, it is widely distributed in various tissues in the body. About 90% of the prototype 3-MCPD will be metabolized by organs, etc., and 3-MCPD will be distributed in the lung, liver, kidney, fat, and large intestine along with the blood. and urine. The third step is metabolism. 3-MCPD first combines with glutathione (GSH) under the action of liver metabolic enzymes to form mercaptouric acid adducts. The fourth step...

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Abstract

The invention relates to the field of food safety, in particular to chemical risk assessment and extraction of internal and external exposure association, and particularly relates to a physiological poison metabolism kinetic model construction method for rat oral exposure to 3-MCPD. The invention discloses a method for constructing a physiological toxicokinetic model of 3-MCPD of a rat. The method comprises the following steps: determining a kinetic process of absorption, distribution, metabolism and excretion of 3-MCPD ingested orally in the rat; the method comprises the following steps: determining a physiological toxicokinetic model of the rat exposed to 3-MCPD through the mouth, and determining an atrioventricular composition structure of the model; establishing a mathematical model, and compiling a differential equation; the method comprises the following steps: collecting physiological parameters of a rat, biochemical parameters of 3-MCPD and toxicokinetic parameters of 3-MCPD; obtaining rat 3-MCPD physiological toxicokinetic model simulation and parameter optimization; and a 3-MCPD daily exposure response relation model is established.

Description

technical field [0001] The invention relates to the field of food safety, in particular to chemical risk assessment and correlation of internal and external exposure, in particular to a physiological toxicant metabolic kinetic model of rats exposed to 3-MCPD orally and a construction method thereof. Background technique [0002] 3-Chloro-1,2-propanediol (3-MCPD) is a colorless viscous liquid with a molecular formula of C3H7ClO2 (CAS No. 96-24-2) and a relative molecular mass of 110.54. It is produced during the refining process of edible oil. Especially the deodorization process. 3-MCPD fatty acid ester is an ester substance formed by 3-MCPD and different fatty acids. It is metabolized and hydrolyzed into 3-MCPD and fatty acid after entering the animal body. Toxicity is comparable, based on 3-MCPD. Due to the wide use of edible oil, it is not only used in the daily cooking process, but also added to various foods, such as: coffee, infant formula milk powder, fried potato c...

Claims

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Application Information

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IPC IPC(8): A61B5/00A61D7/00
CPCA61B5/4845A61D7/00A61B2503/40A61B2503/42
Inventor 章宇贾伟江嘉昊张蓝戈
Owner ZHEJIANG UNIV
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