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Process for screening active components playing weight losing and hypolipemic role from Chinese-herbal medicines

A technology of active ingredients and screening methods, applied in biochemical equipment and methods, microbiological measurement/inspection, etc., can solve problems such as redness, pain, increased energy expenditure, and side effects, and achieve clear targets and clear and reliable mechanisms Effect

Inactive Publication Date: 2002-08-14
PEKING UNIV +1
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Problems solved by technology

The side effects of the two are very obvious, sibutramine causes dry mouth, palpitations, and fatigue, and orlistat causes oily stools and fat-soluble vitamin deficiency
Western countries have also been developing weight-loss drugs based on new principles. For example, it was found that xanthine derivatives can increase energy expenditure by accelerating oxidative metabolism in the body. A large number of clinical trials have proved that caffeine and ephedrine alone The use or combined use has a certain weight loss effect, but it has not been clinically approved because of its side effects that can cause tachycardia and palpitations; in the mid-1990s, the mouse ob gene expression product leptin (leptin) was discovered and cloned , and proved that it has a certain weight loss effect on genetically obese rats, but genetically obese individuals only account for 5-10% of the total number of obese individuals, and this substance causes severe local redness, swelling and pain when injected, so it has also been used so far. Not clinically licensed
To sum up, the main disadvantages of existing weight-loss drugs are large side effects and low clinical efficacy, both of which are related to the unscientific design of drug targets
However, due to limitations such as unclear active ingredients and pharmacological mechanisms of Chinese herbal medicines, traditional Chinese herbal medicines cannot go to the world, so there is no weight-loss drug with independent intellectual property rights in my country so far.

Method used

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  • Process for screening active components playing weight losing and hypolipemic role from Chinese-herbal medicines
  • Process for screening active components playing weight losing and hypolipemic role from Chinese-herbal medicines

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Embodiment

[0034] The specific content of the experimental method involved in the embodiment sees the summary of the invention part, no longer repeats here

[0035] 1. Get 200g of chrysanthemums and decoct them to obtain the water extract of chrysanthemums. The measured soluble solids content is about 50mg / ml. Extract and purify rat fatty acid synthase, and determine the effect of the extract on the enzyme activity. The results showed that: when the concentration of the above-mentioned soluble solids in the bioassay system was higher than 0.2 mg / ml, the activity of the enzyme decreased with the increase of the concentration of the chrysanthemum extract. It is proved that chrysanthemum contains active ingredients that inhibit fatty acid synthase.

[0036] 2. Take 200 g of rhubarb and decoct it to obtain a water extract of rhubarb, and the measured soluble solid content is about 80 mg / ml. Extract and purify rat fatty acid synthase, and determine the effect of the extract on the enzyme ac...

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Abstract

A process for screening the active weight losing-hypolipemic component from Chinese-medicinal materials features that one or more of fatty acid synthetase, acyl-CoA synthetase and the differentiationof mouse and human pre-fat cells to mature fat cells are combined as target of said screening. Its advantages are clear target, and large-scale screening.

Description

Technical field: [0001] The invention belongs to the field of biotechnology, and in particular relates to a method for screening active ingredients in Chinese herbal medicines for weight loss and fat reduction at molecular level and cell level. Background technique: [0002] Obesity is a worldwide medical problem. A large amount of evidence has shown that obesity is closely related to various diseases, such as hypertension, hyperlipidemia, diabetes, cardiovascular and cerebrovascular diseases, breast cancer, female infertility, and mental retardation in children. Taking BMI (Body Mass Index) males greater than 27.8 and females greater than 27.3 as the obesity standard, the total number of obese people aged 18-74 in my country is about 70 million, accounting for 5.8% of the total population; the total number of obese people in the same age population in the United States is about 6800 million, accounting for 20% of the total population. my country's annual consumption for we...

Claims

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Application Information

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IPC IPC(8): C12Q1/02C12Q1/25
Inventor 张崇本邓宏魁丁明孝
Owner PEKING UNIV
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