Production method of nano medicine carrier
A nano-drug carrier and a preparation method technology, applied in the field of nano-drug carrier preparation, can solve the problems of affecting drug loading, difficult to control the degradation rate of materials, difficult to obtain polymer nanomaterials, etc.
Inactive Publication Date: 2004-02-25
张阳德
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However, its research results are mainly completed on in vitro cell models and small animal in vivo models. There are many conditions set during the research process, and the models are relatively simple, far less complex than the human system.
Moreover, the current common nanomaterial preparation technology is difficult to obtain polymer nanomaterials that are completely nanometer-sized. In the powder particle size distribution, the proportion of nanometer-sized parts is very small, which affects the drug loading, and it is difficult to control the degradation rate of the material.
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[0006] Take an equal amount of ferric chloride and ferrous chloride mixture, mix it with 10% ammonia water in a ratio of 3 to 1, and heat it to 70°C to produce ferric oxide with a size of 10 μm. Take 36ml of the above iron ferric oxide solution, 10ml of doxorubicin, and 10ml of albumin, mix them with 200ml of cottonseed oil, put them into a cell disintegrator for ultrasonic mixing, and form drug particles of 100 μm. Then dissolve the grease with ether to obtain the present invention
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The preparation method of nano medicine carrier includes the following steps: utilizes the iron chloride and ferrous chloride mixed liquor and ammonia water to make them produce reaction to obtain tri-iron tetroxide solution; mixing said tri-ion tetroxide solution with amycin and albumen, adding cotton seed oil, placing them into cell disintegrator to make ultrasonic uniformly-mixing and make theparticles in which the amycin and albumen are covered with magnetic iron be dispersed in the oil and fat, then using ethyl ether to dissolve the oil and fat so as to obtain the invented product.
Description
technical field [0001] The invention relates to a preparation method of a nano drug carrier for treating malignant tumors. Background technique [0002] In recent years, the most successful application of nanotechnology in the early diagnosis and treatment of malignant tumors is ferrite nanomaterials and related technologies. However, its research results are mainly completed on in vitro cell models and small animal in vivo models. There are many conditions set during the research process, and the models are relatively simple, far less complex than the human system. Moreover, the current common nanomaterial preparation technology is difficult to obtain polymer nanomaterials that are completely nanometer-sized. In the powder particle size distribution, the proportion of nanometer-sized parts is very small, which affects the drug loading, and it is difficult to control the degradation rate of the material. . Therefore, it is a key issue to find a reliable nanocarrier materia...
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Inventor 张阳德
Owner 张阳德
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