Compound medicine contg. famotidine cyclodextrin clathrate, and its prepn. method

[0107] Preparation of Famotidine-β-cyclodextrin Inclusion Complex

[0108] Famotidine 10g

[0109] β-cyclodextrin 40g

[0110] Purified water 250ml

[0111] Preparation method: Heat 200ml of purified water to about 90°C, keep warm in a water bath, add 40g of β-cyclodextrin and stir continuously, after completely dissolving, cool down to 75-78°C and keep warm in a water bath, add 10g of famotidine, stir until completely Dissolve, then heat and stir for 1 hour, then naturally cool to room temperature to 12 hours while stirring, filter with suction, dry at 50°C for about 4 hours, take it out and pass through a 50-mesh sieve to obtain famotidine-β-cyclodextrin inclusion complex things.

[0113] Preparation of Famotidine-β-cyclodextrin Inclusion Complex

[0114] Famotidine 10g

[0115] β-cyclodextrin 40g

[0116] Purified water 250ml

[0117] Preparation method: heat 800ml of purified water, keep it warm in a water bath, add 40g of β-cyclodextrin and stir continuously, cool down to 50°C in a water bath and keep warm after completely dissolving, add 10g of famotidine, stir until completely dissolved, then cool naturally while stirring Keep warm in a water bath between 40-30°C for 7 days, concentrate under reduced pressure at 50°C to 150ml, filter with suction, dry at 50°C for about 4 hours, take it out and pass through a 50-mesh sieve to obtain famotidine-β-cyclodextrin clathrate, detection.

[0118] 1) The results of differential thermal analysis show that famotidine has an endothermic peak at about 160°C, and β-cyclodextrin has an obvious endothermic peak at 50°C-120°C, which is due to dehydration; famotidine and The physical mixture of β-cyclodextrin has ...

[0121] Preparation of Compound Famotidine Tablets (1000 Tablets)

[0122] Famotidine-β-cyclodextrin (contains famotidine 5g) 25g

[0123] Magnesium hydroxide 165g

[0124] Calcium carbonate 800g

[0125] Microfiber Cellulose 100g

[0126] 40g pregelatinized starch

[0127] Magnesium Stearate 2g

[0128] Preparation:

[0129] Weigh the prescribed amount of calcium carbonate, magnesium hydroxide, microcrystalline cellulose and pregelatinized starch, and put them all in a three-phase mixer and mix them thoroughly for several minutes to make them evenly mixed. Add appropriate amount of 50% ethanol solution, granulate and dry.

[0130] Add the famotidine-β-cyclodextrin inclusion compound and magnesium stearate prepared by the method in Example 2, mix evenly, and compress into tablets.