30 results about "Transurethral route" patented technology

The present invention provides treatment regimens for treating diseased prostate tissue, including the steps of chemically ablating prostate tissue and coadministering an antiandrogen. In some embodiments, prostate tissue is chemically ablated by injection of ethanol, or an injectable gel comprising ethanol, into prostate tissue. Steroidal and non-steroidal antiandrogens are suitable antiandrogens. One suitable non-steroidal antiandrogen is bicalutamide. The treatment regimen is suitable for treatment of prostate tissue diseases including benign prostatic hyperplasia and prostatic carcinoma. The invention further provides a treatment regimen for treating benign prostatic hyperplasia, including the steps of damaging prostate tissue and coadministering an antiandrogen. Also provided by the present invention is a kit for treating a human male, including a means for necrosing prostate tissue, an antiandrogen drug, and a means for administering the antiandrogen drug. A kit including a first surgical device for delivering a chemoablation fluid to prostate tissue transurethrally, an antiandrogen drug such as bicalutamide, and a second surgical device for administering the antiandrogen drug, is further provided.

An inflated implant, such as an attenuation device, previously implanted in a urinary bladder can later be removed according to a number of different methods. Preferably, removal is accomplished transurethrally. In one embodiment, removal is accomplished by reducing the inflated implant from an enlarged profile to a reduced profile so that it may be withdrawn transurethrally by a removal system. The removal system can be configured differently depending upon whether reduction from the enlarged profile to the reduced profile is accomplished by deflation, compression, and / or other ways.

Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical administration of apaziquone immediately following transurethral resection. Also disclosed are therapeutic compositions comprising an indoloquinone compound and a formulation vehicle. The formulation vehicle improves the solubility and stability of the indoloquinone compound. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.

The invention provides a novel transurethral bladder tumor electrocision electrode with a hook-shaped structure. The electrocision electrode comprises a urethral catheter which is smooth in appearanceand free of sharp protruding structures, a sight glass tube and an electrode catheter are arranged in the urethral catheter, an indwelling device sleeving the outer wall of the electrode catheter isarranged in the urethral catheter, and the electrode catheter is slidably connected to the indwelling device through a sliding way; hollow bearings are symmetrically fixed to the two ends of the interior of the electrode catheter, a cable catheter penetrates through the interior of each of the two sets of bearings, and the end, placed in the bladder, of the cable catheter is connected to an electrocision electrode of a hook-shaped structure; the electrocision electrode is convenient to rotate and adjust in the angle direction, the urethral catheter is stably attached to the urethra in the adjusting process, and damage of the catheter to the urethral wall is reduced; and the electrocision electrode is of a hook-shaped structure, the contact surface between the electrocision electrode and atumor is reduced, burn damage to the inner wall of the bladder is reduced during electrocision, the hook end of the hook-shaped structure can lift and tear the tumor to separate the tumor from the inner wall of the bladder, and the electrocision electrode is convenient to use.

The invention discloses a plough-shaped electrode for a transurethral prostate surgery and an application method thereof. The plough-shaped electrode comprises an electrode base body which is of an arc-shaped folded sheet structure matched with a prostate tissue layer and comprising an inwards-concave cambered surface and an outwards-convex cambered surface, wherein the electrode base body comprises a base body, a front cutting part and a rear cutting part; the front cutting part protrudes forwards from the base body in an arc shape; the rear cutting part protrudes backwards from the base bodyin an arc shape; and in the enucleation and cutting process of the transurethral prostate surgery, the outwards-convex cambered surface is arranged to be an electric coagulation hemostasis part. Theplough-shaped electrode for the transurethral prostate surgery provided by the invention has the following advantages: in the use process of a prostate surgery, the functions of enucleating and cutting are realized; the function of enlarging a hemostasis area is achieved; the hemostasis effect and hemostasis efficiency are improved; the efficiency of the transurethral prostate surgery is greatly improved; the operation difficulty and operation risk of the surgery are reduced; meanwhile, bleeding and injuries of a patient in the prostate surgery are reduced; the safety and success rate of the prostate surgery are improved; and benefits are brought to the patient.

The invention discloses a tumor storage and crushing device for transurethral bladder tumor resection. The tumor storage and crushing device comprises a cutting mechanism entering a bladder through aurethra, wherein an operating rod body is further arranged in the cutting mechanism, communicating mechanisms for being externally connected with a water source are arranged in the operating rod body,a tumor storage mechanism is arranged at the end of the operating rod body and is communicated with the communicating mechanisms, and a tissue crushing operation channel is formed between the communicating mechanisms. The tumor storage and crushing device further comprises a tissue crushing mechanism acting on tumors, wherein the tissue crushing mechanism is located in the operating rod body andcomprises a tissue crushing driving wire, the tissue crushing operation channel is formed in the operating rod body, the tissue crushing driving wire and the tissue crushing operation channel performrelative motion, a plurality of protrusions evenly spaced are arranged on the surface of the tissue crushing driving wire in the axial direction, and the situation is avoided that the tissue crushingmechanism shakes during crushing and accordingly crushing operation is affected. The tumor storage and crushing device can wrap, crush and extract the resected tumors and reduce the risk of tumor implantation metastasis.

The invention discloses a transurethral optical-acoustic prostate imaging method and device based on ring array receiving. The device comprises a pulse laser source excitation system, an optical fibercatheter scanning system, a ring array detector probe system, a signal collecting and conditioning system and a data processing system. Pulse laser is guided into the urethra through an optical fibercatheter, the pulse laser is irradiated to the portion to be tested of the prostate through rotating scanning, and therefore optical and acoustic signals are excited; the ring array detector is usedfor scanning and parallel receiving of full-angle optical and acoustic signals, the received optical and acoustic signals are amplified and filtered and converted into digital signals through a multi-channel signal collecting system, denoising is performed through the data processing system, and rebuilding and display are performed. The optical fiber catheter is used for transurethral internal full-angle and large-facula mechanical rotating excitation, the ring array detector performs electronic scanning and collecting, and prostate tissue full-range, high-contrast, high-resolution and rapid imaging can be achieved.

The invention relates to a novel anti-tumor epirubicin compound being an epirubicin hydrochloride v-type compound, wherein the novel compound is easy to prepare and has advantages of less hygroscopicity, improved storage stability, good promotion of drug quality control and the like. The novel anti-tumor epirubicin compound is used for application in treatment and preventive drugs for treatment ofthe malignant lymphomam, breast cancer, lung cancer, soft tissue sarcoma, esophageal cancer, gastric cancer, liver cancer, pancreatic cancer, melanoma, colorectal cancer, ovarian cancer, multiple myeloma, leukemia, and brain glioma, treatment of the superficial bladder cancer and carcinoma in situ by the intravesical administration, and prevention of recurrence after transurethral resection and the like.

The present invention is directed to bladder cancer specific ligand peptides, comprising the amino acid sequence X1DGRX5GF (SEQ ID NO:1), and methods of their use, e.g., for imaging detection for diagnosis of bladder, tumor localization to guide transurethral resection of bladder cancer, imaging detection of bladder cancer for follow-up after the initial treatment that can replace or complement costly cystoscopy, imaging detection of metastatic bladder cancer, and targeted therapy for superficial and metastatic bladder cancer.

The invention discloses an operation handle for a transurethral minimally invasive surgery for prostate. The operation handle comprises an endoscope sheath, a fixed handle fixed on the endoscope sheath, and a sliding block arranged on the endoscope sheath in a sliding manner, wherein an endoscope is arranged in the endoscope sheath; an electric resection rod and an optical fiber are arranged at the outer side of the endoscope sheath, are arranged along the length direction of the endoscope sheath, and can move relative to the fixed handle; a through hole for the electric resection rod and theoptical fiber to pass through is formed in the sliding block; adjusting holes are formed in the sliding block; the adjusting holes communicate with the through hole; and an adjusting knob for fixing the optical fiber or the electric resection rod in the sliding block is arranged in each adjusting hole. Different surgical methods can be adopted to operate a patient without replacing a surgical instrument under the condition of using the same operation handle, so that the problem that the operation handle needs to be replaced according to actual conditions in a surgical process is solved.

A novel and useful highly maneuverable and disposable resectoscope having a working element such that surgeons are able to more comfortably perform transurethral resections. The resectoscope permits the surgeon to resect anywhere on the bladder or prostate wall while keep their hand in an ergonomic position. This results in more comfortable surgery that causes less fatigue for the surgeons as well a quicker, safer, and more effective operation. The disposable resectoscope includes a completely disposable design, an analog or digital optics system, a handle that is independently rotatable from the remainder of the resectoscope, a rotation mechanism that can independently rotate an electrocautery electrode and optical lens independent of the handle rotation, and a repositioning of surgical cords and cables for a more comfortable hand placement.

The invention discloses a visualized transurethral prostate balloon dilation catheter and a monitoring system, and belongs to the technical field of medical instruments, the visualized transurethral prostate balloon dilation catheter comprises a catheter body, a mounting seat is mounted at one end of the catheter body, and an observation opening is formed in the end, away from the mounting seat, of the catheter body; two adjacent pairs of water distribution sections are arranged at the end, close to the observation opening, of the catheter body, the outer edges of the water distribution sections are sleeved with balloon bodies, a cavity channel is formed in the catheter body, a blocking pipe is transversely installed in the cavity channel and transversely penetrates through the cavity channel, a passing cavity is formed in the blocking pipe, and a through hole is formed in the passing cavity. And an endoscope is arranged at the passing cavity. According to the visual transurethral prostate balloon dilation catheter and the monitoring system, when the catheter works, a channel allowing an endoscope to pass through can be independently formed, then the position of the catheter at the moment can be observed through the endoscope, and the problem that the catheter body of an obese patient cannot be accurately positioned can be solved as much as possible.

The invention provides a novel hook-shaped electrode for transurethral resection of bladder tumors, which includes a urethral catheter with a smooth appearance and no sharp protruding structure. The inside of the urethral catheter is provided with a speculum tube and an electrode catheter. There is an indwelling device sleeved on the outer wall of the electrode catheter inside, and the electrode catheter and the indwelling device are slidably connected through the slideway; hollow bearings are symmetrically fixed at both ends of the electrode catheter, and the two groups of The inside of the bearing runs through a cable conduit, and one end of the cable conduit inserted into the bladder is connected with a hook-shaped electric cutting electrode; the angle and direction of the electric cutting electrode can be rotated and adjusted conveniently, and the urethral catheter is smoothly attached to the urethra during the adjustment process. Reduce the damage of the catheter to the urethral wall; the electric resection electrode has a hook-shaped structure, which reduces the contact surface with the tumor, and reduces the burn damage to the inner wall of the bladder during electric resection, and the hook end of the hook-shaped structure can lift and tear the tumor, and the tumor It is easy to use because it is separated from the inner wall of the bladder.

According to the technical scheme, a prostate coagulated tissue digging tool for the prostate digging operation is provided with an insulating hollow catheter capable of penetrating into the prostate through the urethra, a rotary knife tube capable of rotating is installed at the front end of the catheter, a knife hole is formed in the rotary knife tube, and a needle-knife mechanism capable of stretching out and drawing back along the knife hole is arranged in the rotary knife tube. A power shaft capable of moving and rotating along the catheter is arranged along the hollow catheter, the needle-knife mechanism is controlled by the front end of the power shaft to enable a needle-knife to extend out of a knife hole of the rotary knife tube, and meanwhile, the front end of the power shaft is in transmission fit with the rotary knife tube to rotate to drive the extending needle-knife to quickly cut off coagulated and necrotic prostate tissue. The tool has the beneficial effects that equipment operation is realized in the prostate digging operation, so that the accuracy of the digging operation is improved, the operation difficulty is reduced, the operation time is shortened, the digging operation becomes simple, and the operation risk and the operation cost of the prostatic hyperplasia digging operation are reduced.

The present invention is a transurethral bladder communication device, which is characterized in that the communication body includes a buffer chamber and a drug administration chamber, the top of the buffer chamber is connected to the animal catheter, and the bottom end is provided with a buffer chamber sealing rubber plug. A central hole is provided in the buffer chamber plugging rubber plug, the annular wall of the buffer chamber is connected to the bottom end of the connection port, the top end of the connection port is sealed to one end of the drug delivery tube, and the other end is sealed to the top end of the drug delivery chamber. The bottom end of the drug delivery cavity is provided with a drug delivery cavity seal, the inner core includes a metal inner core, a base and a handle, the base is connected and fixed to the handle, the base is provided with a through hole, and the bottom of the metal inner core The end is inserted and fixed in the through hole. The invention provides a minimally invasive communication device for infusing the bladder of experimental animals with medicinal liquid and subsequent laser irradiation treatment through the urethra, so as to achieve the purpose of safety, effectiveness and minimal invasiveness.

The present disclosure relates to systems and methods for controlling pressure during percutaneous and endoscopic surgeries, including percutaneous renal procedures, endoscopic uterine procedures, transurethral endoscopic procedures for the bladder or prostate, or any percutaneous or endoscopic procedure. The system can include a sheath and / or endoscope each having an inflow port providing access to an inflow channel extending from the inflow port to a distal portion of the sheath, and an outflow port providing access to an outflow channel extending from the outflow port to the distal portion of the sheath. The sheath can also include a pressure sensor configured to generate a pressure measurement, and an electronic processor configured to control fluid through at least one of the inflow port and the outflow port based on the pressure measurement.

[Object]The present invention is intended to provide a urethral stricture treatment agent and a urethral stricture treatment method capable of avoiding restenosis by a less invasive transurethral endoscopic procedure in urethral stricture treatment.[Solution]A urethral stricture treatment agent including at least a hydrogel-forming polymer, and having a storage elastic modulus of 50 Pa or less at 10° C. and a storage elastic modulus of 100 Pa or more at 37° C.A urethral stricture treatment method at least including injecting the urethral stricture treatment agent cooled to 10° C. or lower into an inner surface of urethra which has been incised with a transurethral endoscopic procedure, and holding the urethral stricture treatment agent in the inner surface of urethra at a temperature not lower than a room temperature.

A prostate treatment system having a light delivery device positionable in a transurethral device for treatment of benign prostatic hyperplasia (BPH). The light delivery device includes light generator, such as light emitting diodes (LED), laser diodes (LDs) or a diffusion quartz fiber tip connected to a light generator or a light emitting polymer which produces light at a selected wavelength or waveband or alternative sources of suitable light energy. The treatment device may further include a temperature monitoring system for monitoring the temperature at the treatment site. A light-activated drug is administered to the treatment site prior to light activation. The light-activated drug therapy induces cell death of the target tissue. The device provides a minimally invasive transurethral method for treatment of BPH or prostate cancer.

An embodiment in accordance with the present invention provides a device and method for the treatment of urethral stricture. The present invention places and holds a graft at an incised urethral stricture site for 5-21 days, while the graft adherences to the incised urethral stricture site. A device of the present invention includes a delivery component, a graft carrier component, and a removal component. In some embodiments, the delivery and removal components may be combined into the same device. The delivery component, the graft carrier component, and the removal component are all configured to enter and exit the urethra without trauma. A method according to an embodiment of the present invention includes harvesting a graft, loading the graft onto the graft carrier component, introducing the delivery device into the urethra with the graft carrier component and graft loaded, and delivering of the graft to the incised urethral stricture site.

The invention relates to a transurethral prostate sampling device and a manufacturing method thereof. The transurethral prostate sampling device comprises an outer sleeve assembly suitable for being inserted into the prostate of a patient through the urethra of the patient, and a window is formed in the outer sleeve assembly; a middle tube assembly adapted to be mountable within the outer sleeve assembly and operably movable relative to the outer sleeve assembly in a direction parallel to a central axis of the outer sleeve assembly, the middle tube assembly comprising a first deflection mechanism; and a sampling needle, wherein the tail end comprises a first section for sampling from the prostate of a patient; the sampling needle can be at least partially arranged in the middle tube assembly; the sampling needle is adapted to operably move relative to the central tube assembly in a direction parallel to the central axis, at least a portion of the sampling needle is engageable with thefirst deflection mechanism by engaging movement of the sampling needle relative to the central tube assembly such that the first segment passes through the window at a deflection angle relative to thecentral axis.

The invention relates to a transurethral prostate treatment device, and belongs to the technical field of medical instruments, the transurethral prostate treatment device comprises a tube body with an insertion end and an indwelling end, the tube body comprises an outer wall and an inner wall, the outer wall and the inner wall are sealed to form an annular cavity, the outer wall and the inner wall are both elastic films, an expansion structure is arranged in the annular cavity, and the inner wall is provided with an opening. The expansion structure comprises a plurality of supporting pieces fixed to the outer wall, the supporting pieces are arranged in the annular cavity in the circumferential direction at equal intervals, an elastic piece is connected between any two adjacent supporting pieces, and positioning bags and fixing bags are arranged on the outer surface, close to the insertion end, of the outer wall at intervals. A first air inflation bag, a second air inflation bag and a third air inflation bag are arranged on the outer wall close to the indwelling end, and a massage structure is arranged between the positioning bag and the fixing bag. Through the creative design, the tube body has the contraction capacity, the adaptability is enhanced, the safety is higher, the treatment means are increased, the prostate area can be dynamically massaged, and the treatment effect is promoted.

Bladder cancer treatments include the intravesical administration of apaziquone immediately (e.g. within about 6 hours) following transurethral resection.

The invention provides a prostate tissue coagulation device for a prostate excavation operation. The prostate tissue coagulation device comprises a catheter, an air bag, an air delivery pipe, an air charging device, a coagulation pipe, a wire and a coagulation control device, wherein the catheter is an insulated hollow pipe capable of penetrating into the bladder through the urethra; the air bag is fixedly arranged on the front end of the catheter; the air delivery pipe is arranged along the inside of the catheter, one end of the air delivery pipe fixedly communicates with the air bag, and the other end of the air delivery pipe extends out of the rear end of the catheter and communicates with the air charging device; the coagulation pipe is fixedly arranged at a part, which is close to the front end of the catheter, of the catheter; the wire is arranged along the inside of the catheter, one end of the wire is connected with the coagulation pipe, and the other end of the wire extends out of the rear end of the catheter and is connected with the coagulation control device; the air charging device communicates with the air bag through the air delivery pipe; and the coagulation control device is connected with the coagulation pipe through the wire. The prostate tissue coagulation device has the beneficial effects that the operation is simple, the positioning speed is high, the operation time is shortened, the bleeding problem in the prostate excavation operation process is solved, the operation risk is reduced, and the recovery speed is improved.

The invention relates to a multi-visual transurethral prostate needle biopsy system and a use method thereof. The multi-visual transurethral prostate needle biopsy system comprises a base, a ureteroscope and a puncture needle, a camera and an ultrasonic probe are arranged at the front end of the ureteroscope, a puncture sleeve is arranged at the bottom of the outer side face of the ureteroscope in parallel, and a needle body of the puncture needle slidably penetrates through the puncture sleeve; and the base comprises an outer sleeve used for being inserted into the urethra, the outer sleeve slidably sleeves the outer side of the ureteroscope and the puncture sleeve, and a driving mechanism used for driving the puncture needle to move forwards along the puncture sleeve is arranged at the rear end of the outer sleeve. Precise prostate needle biopsy of a transurethral sterile part is achieved, infection is effectively avoided, bleeding can be stopped under direct vision after puncture, postoperative bleeding can be reduced, the puncture qualification rate is increased, and pain of a patient is relieved; and cleaning is achieved through a flushing assembly and a waste liquid discharging assembly, bleeding inflammation adhesion around the prostate is reduced, cleaning of an operating table is achieved, and smooth proceeding of subsequent surgical operation is facilitated.

The miniature ultrasonic radar ranging device is provided with a probe rod body, a probe rod electrode is arranged in the probe rod body, one end of the probe rod electrode is left in the probe rod body, one end of the probe rod electrode left in the probe rod body is connected with a probe rod head, the probe rod head comprises a probe rod front fork and a probe base, and a miniature ultrasonic probe is arranged on the probe base. The miniature ultrasonic radar distance measuring device for the resectoscope is an ultrasonic distance measuring device capable of being carried on the resectoscope, meets the clinical requirement of an operator for directly observing the shape of an operation area in transurethral electric resection, and solves the problem that ultrasonic waves in the transabdominal, perineum or rectum ways cannot be directly observed. The problems of inconvenience, non-intuition and non-direct measurement of an ultrasonic cystoscope are solved, so that when a urology surgeon uses a resectoscope to carry out intracavitary operation on the prostate urethra, the intracavitary anatomical structure can be conveniently measured, the intracavitary structure change of an operation area after operation intervention can be timely known, and a subsequent operation scheme can be better formulated.