A Method for the treatment of 
skin fibrosis with 
a peptide that inhibits TGF-β, and suitable compositions for its administration. The method includes in particular, the use of 
peptide P144, a compound that is a known inhibitor of TGF-β, for the treatment of 
skin fibrosis by topical application. The method is shown effective in an 
animal model of 
bleomycin-induced 
skin sclerosis, to a reduction both of the skin 
fibrosis and of the content of soluble collagen, without any signs of 
systemic toxicity being detected. This shows that P144 is effective for topical application in mammals for treating fibrotic skin diseases and 
pathological scarring of the skin. For the administration of this 
peptide, stable compositions are also supplied, with pleasant appearance without being greasy, with good spreading characteristics and with a 
viscosity that permits it to be processed easily in industrial 
plant, and which are suitable for administering the 
peptide to humans.