A novel patient-convenient, cost effective pharmaceutical composition, comprising of thiazolidinediones and 
biguanide for controlling hyperglycemia manufactured as 
multilayer tablet and its process of manufacturing, for 
immediate release of thiazolidinediones or thiazolidinediones and 
biguanide and 
prolonged release of the 
biguanide only, the tablet comprising of minimum two 
layers wherein one outer layer comprises of a mixture of excipients and thiazolidinediones or thiazolidinediones and biguanide allowing 
immediate release of thiazolidinediones or thiazolidinediones and biguanide respectively and the other layer arranged in contact with the 
immediate release layer which comprises of a novel composition of excipients and a minimum one or more non-biodegradable, 
inert polymer(s) and the biguanide allowing 
pH independent prolonged release of the biguanide up to a period of 8-12 hours. The tablets are for once a day dosing. The tablets may optionally be film coated or enrobed by soft 
gelatin ribbons for additional protection against oxidation, 
photodegradation, identification, ease of 
swallowing, 
taste masking and for aesthetic appeal without altering the 
dissolution profile.