64results about How to "Fast drug release" patented technology

A granular pharmaceutical composition for oral administration, wherein a drug-containing particle is coated with a coating comprising a methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer and a water-soluble polymer is disclosed.

The invention provides a traditional Chinese medicine externally applied preparation for the treatment of gynecological diseases and a preparation method thereof. The traditional Chinese medicine externally applied preparation is prepared by lightyellow sophora root, common cnidium fruit, amur corktree bark, pink plumepoppy herb, red earth Indian buead, liquid extract which is extracted from the effective parts of pomegranate rind and dried alum super-fine powder, wherein, an effervescent suppository preparation is prepared by adding polyethylene glycol, organic acid, hydrogen carbonate salt or carbonate salt or Tween 80 in the ingredients. The invention takes the lightyellow sophora root and the common cnidium fruit as monarch drugs, the amur corktree bark, the pink plumepoppy herb and the red earth Indian buead are taken as auxiliary drugs, the pomegranate rind and the dried alum are taken for assistance, the effective rate for the treatment of gynecological diseases can achieve more than 90 percent, and the invention has no stimulus, toxicity or side effects, thus being the safe and reliable pure traditional Chinese medicine externally applied preparation. The effervescent suppository preparation is further provided, the usage is convenient, the patient compliance is increased, and the preparation process is relatively simple.

The invention relates to a traditional Chinese medicine preparation-Liuwei Anxiao Pills and a preparing method of the traditional Chinese medicine preparation, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is characterized by comprising the following components in weight percent: 40-55 parts of Tibet inula, 160-200 parts of rhubarb, 80-100 parts of Kaempferia galangal, 200-250 parts of Gypsum Gypsum Rubrum, 110-150 parts of myrobalan and 250-300 parts of Tronae. In the preparing method, on the basis of the traditional process, the original single crushing pattern is changed, a sterilization process is changed, i.e. the original moist heat sterilization process for medicine powder produced after medicinal slices are crushed is changed into a cobalt 60 irradiation process, and the pattern of collecting and coating volatile oil is changed. The preparing method sufficiently ensures that volatile components in the Tibet inula are not lost and oily components in the Tibet inula are not lost. In addition, the drug effect is more effectively ensured, the product name quality is ensured, and benefits of patients are guaranteed.

The invention discloses orally disintegrating clozapine tablets prepared by 3D printing. The orally disintegrating clozapine tablets are prepared from the following components in percent by weight bya 3D printing technology: 10-60% of clozapine, 30-90% of a filling agent, 1-10% of a dry adhesive, 0-1.0% of silica gel micropowder and 0-2% of a corrigent. The invention further discloses a preparation method of the orally disintegrating clozapine tablets. The orally disintegrating clozapine tablets provide by the invention are high in disintegrating speed, do not need a large amount of water fordelivery, and can be quickly disintegrated in an oral cavity when saliva is encountered, which is of a great significance in improving the medicine-taking success rate and the compliance of a patientsuffering from psychosis.

The invention relates to a self-emulsified terbinafine hydrochloride cream and preparation method thereof, comprising, main medicaments, terbinafine hydrochloride of 0.5-3%, TEFOSE63 (polyethylene glycol-7 stearate) of 6-18%, span 80 of 1-6%, glycerin monostearate of 1-5%, and light liquid petrolatum of 1-4%; the remainder being purified water. Self-emulsifier, surfactant and solvent are heated to 75-80 DEG C, rapidly stirred for 30-45 minutes after complete dissolution, and cooled to around 40 DEG C; maintaining the temperature, the terbinafine hydrochloride is added and stirred continuously; triethanolamine of proper amount is added to regulate the pH value between 4-6, vacuumized, and continuously stirred to the room temperature to obtain the cream with good brightness, good coating ability, less consistency change with the environmental temperature change, good stability and transdermal absorption. Compared with the traditional preparation technology, the preparation method thereof is simple in operation, low in the energy consumption and low in device investment.

The invention provides a long-term-preserved immune cell gel preparation and a preparation method thereof. The gel preparation contains immune cells and a gel matrix, wherein the gel matrix mainly contains the following components: deionized water, dextran, a mistletoe leaf extract, propylene glycol alginate, oleyl alcohol and guaiacum. The method comprises the following steps: preparing the mistletoe leaf extract; and dissolving the mistletoe leaf extract into deionized water, standing for one night, adding propylene glycol alginate, oleyl alcohol and guaiacum, stirring, adding dextran, stirring, preparing the gel matrix, adding the immune cells into the gel matrix, and uniformly stirring. According to the preparation method, the cell activity of the immune cells in a long-term preservation process can be guaranteed, meanwhile, the stability of the immune cell gel preparation can be improved, the pesticide effect of the long-term-preserved immune cell gel preparation can be guaranteed, the drug release efficiency can be improved, and the mildewing can be prevented; and the immune cell gel preparation is strong in practicability.

The present invention is a kind of kind of compound isatis root effervescent tablet and its preparation process. The compound isatis root effervescent tablet is prepared with isatis root, isatis leaf and proper amount of supplementary material. Compared with available technology, the compound isatis root effervescent tablet of the present invention has the advantages of fast medicine release, quick acting, high bioavailability, high stability, etc. and is especially suitable for children, old people and patient with dysphagia.

The invention relates to a Chinese medicinal soup for treating tuberculosis, diabetes, hypertension, cardiovascular and cerebrovascular diseases, as well as kidney diseases, which is prepared from Siberian solomonseal rhizome, fleece-flower root, bletilla striata, spatholobus stem and glutinous rice through mincing. The soup can be used for breakfast.

The invention belongs to the pharmaceutical preparation technology field and discloses a pancreatin enteric coating pellet. The pancreatin enteric coating pellet is prepared from a pancreatin pellet, a separant and an enteric coating liquid. The formula of the pancreatin pellet comprises pancreatin powder, diluents, disintegrating agents and adhesives. The formula of the enteric coating liquid comprises enteric coating materials, antitackiness agents, plasticizers and purified water. The invention also provides a preparation method for the pancreatin enteric coating pellet. The pancreatin enteric coating pellet is advantaged by high stability, low irritability, high safety factor and rapid drug release degree. The preparation method is simple and practicable, the quality is reliable, and the method can be implemented and worthy of further industrial popularization.

The invention discloses amino-acid-based polyesteramine micelles, a preparation method and application thereof in treating infection wounds. The amino-acid-based polyesteramine micelles are antibacterial micelles prepared by synthesizing amino-acid-based polyesteramine random copolymer from various natural amino acids, and wrapping or grafting the copolymer with an antibacterial drug. The preparation method includes: preparing amino-acid-based polyesteramine random copolymer; synthesizing polyesteramine copolymer grafted with an antibacterial drug, namely antibacterial polyesteramine; preparing polyesteramine solution with the polyesteramine random copolymer, mixing the polyesteramine solution with an antibacterial drug solution to obtain antibacterial micelles I; alternatively, preparingantibacterial polyesteramine solution with antibacterial polyesteramine to obtain antibacterial micelles II. Various copolymer materials can be synthesized herein by changing the ratio of raw components to a hydrophobic unit; compared with block copolymers, the amino-acid-based polyesteramine micelles have the advantages of good simplicity of preparation process, controllable structure and the like. The micelles prepared herein are of nano structure, have more stable structure and can gain improved antibacterial property.

The invention belongs to the field of pharmaceutical preparations and relates to a donepezil hydrochloride oral instant film agent adopting a simple technical process and a preparation method of the donepezil hydrochloride oral instant film agent. The oral instant film agent with good taste, provided by the invention, is prepared from the following components in percentage by weight: 1 to 40 percent of donepezil hydrochloride, 20 to 80 percent of film-forming material, 1 to 20 percent of plasticizer, 1 to 20 percent of taste masking agent, 10 to 30 percent of filler and 0 to 5 percent of otherauxiliary materials. The preparation method is simple; the donepezil hydrochloride oral instant film agent is prepared by directly dissolving all the components in an appropriate solvent, uniformly dispersing, coating on a backing material and drying. The prepared film agent has the advantages of uniform and smooth appearance, good physical and mechanical properties, high dissolution speed and good taste; in addition, the donepezil hydrochloride oral instant film agent is easy to carry and can improve the compliance of medication of patients with Alzheimer's disease.

The invention relates to a clindamycin phosphate vaginal expansive suppository as well as a preparation method and a detection method thereof. The expansive suppository consists of a medicated substrate consisting of clindamycin phosphate and a substrate as well as an expansion carrier, wherein the medicated substrate is added with xylitol, dodecyl gallate and triglycerin octyl caprate. The prepared expansive suppository has the effects of high stability, uniform dispersion and the like; meanwhile, the expansive suppository, which is coated with a film coating outside, overcomes hygroscopicity of clindamycin phosphate, and is rapid in drug release and rapid to become effective in the vagina; the disclosed clindamycin phosphate vaginal expansive suppository, through six unique leading technologies, has the beneficial effects of being capable of preventing medicine liquid leakage, avoiding secondary infection and the like.

The invention relates to a self-emulsified terbinafine hydrochloride cream and preparation method thereof, comprising, main medicaments, terbinafine hydrochloride of 0.5-3%, TEFOSE63 (polyethylene glycol-7 stearate) of 6-18%, span 80 of 1-6%, glycerin monostearate of 1-5%, and light liquid petrolatum of 1-4%; the remainder being purified water. Self-emulsifier, surfactant and solvent are heated to 75-80 DEG C, rapidly stirred for 30-45 minutes after complete dissolution, and cooled to around 40 DEG C; maintaining the temperature, the terbinafine hydrochloride is added and stirred continuously; triethanolamine of proper amount is added to regulate the pH value between 4-6, vacuumized, and continuously stirred to the room temperature to obtain the cream with good brightness, good coating ability, less consistency change with the environmental temperature change, good stability and transdermal absorption. Compared with the traditional preparation technology, the preparation method thereof is simple in operation, low in the energy consumption and low in device investment.

The invention discloses a preparation method of a terbinafine hydrochloride liniment. The preparation method comprises steps as follows: materials are prepared in parts by weight according to a formula in the following; after all materials in the formula are uniformly crushed, the crushed materials are put in a stirrer, 30-40 parts of distilled water are added, and the mixture is mixed and stirredat the stirring speed of 2,500 r / min; after the mixture is uniformly stirred, the mixture is heated to 90-100 DEG C for 30-50 min and then sieved by a sieve of 150 meshes and a filtrate is retained;after the filtrate is concentrated in a vacuum manner to be sticky, and a mixed sticky drug with the relative density being 1.1-1.3 is obtained; the pH value is adjusted to be 3-6, and the drug is stirred uniformly and cooled to the room temperature; the drug is emulsified for 30-50 min until uniformly mixed colloid is obtained, that is, the terbinafine hydrochloride liniment is obtained. The liniment has good glossiness and coating property, paste has small consistence changes with changes of environment temperature and is stable, the drug release speed is high, the transdermal absorption property is good, and compared with a conventional preparation technology, the preparation method has the advantages that the preparation method is simple and easy to operate, quality control is easy, medication is convenient, and the drug has small irritation to skin, good in treatment effect and stable in quality.

The invention discloses children's four-vitamin calcium gluconate effervescent tablets and a preparation method thereof. According to the effervescent tablets, vitamin B1, vitamin B2, vitamin C, vitamin D2, calcium gluconate and glucose are taken as raw materials, and total effervescent tablets containing 1000 tablets comprise the following raw materials: 0.4 g of vitamin B1, 0.2 g of vitamin B2, 5 g of vitamin C, 140 thousand units of vitamin D2 calculated according to 40 thousand units / mg, 300 g of calcium gluconate, 300 g of glucose, and 80%-60% by weight of auxiliary materials accounting for the total tablets. The children's four-vitamin calcium gluconate effervescent tablets are prepared by a special technology, and are good medicine for supplementing vitamins and calcium in children bodies as a vitamin and calcium supplement medicine; and the children's four-vitamin calcium gluconate effervescent tablets have the characteristics of being high in bioavailability, good in mouthfeel, convenient to use, easily accepted by children, convenient to carry and the like. Because of the auxiliary materials and the annular effervescent tablets, the children's four-vitamin calcium gluconate effervescent tablets can be rapidly disintegrated.

The invention discloses an amlodipine besylate orally disintegrating tablet prepared through 3D printing and a preparation method of the orally disintegrating tablet. The amlodipine besylate orally disintegrating tablet is prepared from components in percentage by mass as follows: 1%-8% of amlodipine besylate, 78%-98% of filler, 1%-10% of a dry adhesive, 0.1%-1.0% of aerosil and 0-2% of a flavoring agent with a 3D printing technology. The amlodipine besylate orally disintegrating tablet prepared with the 3D printing technology has the characteristics of being high in disintegration speed, capable of improving drug taking compliance of patients and the like and is particularly convenient to take by old people, children and people with swallowing difficulty. The dosage suitable for the patients can be customized according to the individual difference of the patients, individualized drug administration and accurate treatment are realized, so that the number of tablets taken by the patients or the step of tablet cutting by a pharmacist can be reduced, the pharmaceutical preparation can play the maximum effect, and the toxic and side effects of the medicine can be minimized.

The invention discloses a bazedoxifene acetate composition with excellent properties. The composition comprises bazedoxifene acetate, polyethylene glycol (PEG) 6000-8000 and vitamin E tocopherol polyethylene glycol succinate (TPGS), wherein a solid solution and / or solid sol is formed by polyethylene glycol (PEG) 6000-8000 and vitamin E TPGS, and bazedoxifene acetate is dispersed into the solid solution and / or solid sol. The composition is high in chemical stability and medicine release speed.

The invention relates to a self-microemulsion of forsythia volatile oil, which is characterized in that the self-microemulsion is prepared from the following raw materials in parts by weight: 10 partsof ethyl oleate, 81 parts of tween-20, 9 parts of ethanol and 11-25 part of forsythia volatile oil. The invention also provides a preparation method of the self-microemulsion of the volatile oil of Forsythia suspensa, wherein the self-microemulsion of the volatile oil of Forsythia suspensa produced by the invention has the advantages of clear and transparent appearance, uniform light blue emulsion, particle size less than 100nm, and good stability.

The invention discloses biochemical oral liquid, which takes Chinese angelica, Szechuan lovage rhizome, peach seed, dried ginger and liquoric root as active pharmaceutical ingredients, the active pharmaceutical ingredients are prepared into liquid extract by adopting the modern process, and a flavoring agent, a surfactant and a preservative are further added for preparing the oral liquid. A modern pharmaceutical technology is applied for changing biochemical pills to the oral liquid formulation which is easy to accept by women, thereby overcoming the shortcoming of being inconvenient to take orally of the original formulation; and the biochemical oral liquid is fast in medicament release speed, high in bioavailability, small in irritation, accurate in divided dose, small in volume and convenient to take and carry. The quality standard of the biochemical oral liquid is comprehensively improved on the original basis, a scientific qualitative and quantitative control method is provided, and the product quality is ensured.

The present invention relates to soft mycosporin capsule for vagina and its preparation process. Each of soft mycosporin capsules contains mycosporin in 50-300 mg and medicinal supplementary material vaseline and paraffin, and the capsule shell contains gelatin in 10 weight portions and glycerin in 4.0-5.5 weight portions. The preparation process includes the steps of dissolving gelatin in water and adding glycerin and proper amount of preservative, vacuum deairing, mixing mycosporin and medicinal supplementary material, and pressing into soft capsule. Compared with available mycosporin preparation forms, the soft mycosporin capsule has the advantages of stable quality, convenient carrying and administration, and fast leaching of the effective components.

The invention discloses a traditional Chinese medicine composite for treating a headache and a preparation method of the traditional Chinese medicine composite. The traditional Chinese medicine composite is prepared by ligusticum wallichii, rhizoma gastrodiae, angelica dahurica, radix paeoniae alba, rhizoma corydalis and scorpion. According to the traditional Chinese medicine composite and the preparation method, the traditional Chinese medicine composite is centralized in effective part, small in dosage and convenient to take, and a modern pharmacology research verifies that the traditional Chinese medicine composite is precise in curative effect, safe, reliable, fewer in adverse effect, and used for treating the headache. The traditional Chinese medicine composite has effects of promoting blood circulation, dispelling wind, dredging collaterals and alleviating a pain, and can be used for prevention and treatment of various headaches such as migraine and a tension headache.

The invention relates to a drug-loaded polyvinyl alcohol microsphere and a preparation method thereof. The polyvinyl alcohol microsphere is prepared from a cellulose acetate butyrate solution, a macro-molecular monomer solution, acrylamide-2-methylpro panesulfonic scid sodium salt solution, potassium persulfate and the like. The polyvinyl alcohol microsphere has the characteristics of high drug absorptive amount, high drug release speed, high roundness and good dispersity of microsphere appearance and small and uniform grain size distribution.

The invention discloses effervescent tablets for preventing oral ulcer and a preparation method therefor. The effervescent tablets are prepared from the ingredients in parts by weight: 10 to 20 parts of active component, 20 to 40 parts of disintegrant, 5 to 15 parts of filler and 2 to 6 parts of lubricant, wherein the active component contains the following ingredients: carrots, tremella fuciformis, kiwi-fruit, acanthopanax root, ligustrum lucidum, cordyceps sinensis, Chinese yam rhizome, dates, caryophyllaceous ginseng, glycyrrhiza uralensis, linden honey, sea buckthorn and grapefruit. According to the effervescent tablets for preventing oral ulcer and the preparation method therefor, a variety of natural components with different effects are combined together and are compounded by a simple process, the prepared effervescent tablets play roles in enhancing organism immunity, nourishing Yin and promoting salivation and supplementing various vitamins and trace elements essential to human so as to fundamentally condition bodies, and thus the occurrence of oral ulcer is prevented.

The invention discloses sequential release double-drug-loading hydrogel, which is prepared by taking PBAE as a carrier material, loading vancomycin and forming the hydrogel with rhizoma drynariae general flavone nano-microspheres, and the material realizes sequential release of vancomycin and rhizoma drynariae general flavone, and has the advantages that the time sequence release of vancomycin and rhizoma drynariae general flavone is realized; and the two can play a synergistic effect to better promote the generation of osteoblasts, thereby having an application prospect in bone repair treatment.

The invention discloses a nifedipine sustained-release tablet and a preparation method thereof. The nifedipine sustained-release tablet is a double-layer tablet, wherein the outer-layer tablet is prepared from the following raw materials: nifedipine, microcrystalline cellulose, spray-dried lactose, sodium dodecyl sulfate, copovidone, superfine silica powder and magnesium stearate by using a direct powder compression method; and the inner-layer tablet is prepared from the following raw materials: nifedipine, lactose, pregelatinized starch, hydroxypropyl cellulose, sodium alginate, potassium alginate, povidone, PEG6000, polyvinylpyrrolidone and magnesium stearate. The preparation method comprises the steps of preparing a nifedipine dispersoid from nifedipine, povidone and PEG6000 by using a solvent evaporation method; and then, carrying out wet granulation on the nifedipine dispersoid and other raw materials to prepare the inner-layer tablet. The outer-layer tablet of the nifedipine sustained-release tablet is prepared by using the direct powder compression method, so that disintegration is high, and the required blood concentration is rapidly reached within short time; and the inner-layer tablet formed by compounding the hydroxypropyl cellulose, sodium alginate and potassium alginate is used as a gel sustained-release framework and can be completely released within 24h.

The invention discloses a Chinese herbal medicine for killing insects in aquatic culture. The Chinese herbal medicine is prepared from the following medicinal materials according to a proportional ratio by mass: 10 to 15 parts of Chinaberry barks and 3 to 5 parts of Chinaberry fruits, and is prepared by the following steps of putting the Chinaberry barks and the Chinaberry fruits into a medicine boiler according to the proportional ratio, adding 500 to 800 parts of drinking water according to a mass ratio, heating, boiling for 30 to 45h, filtering, removing medicine residues, and collecting amedicine liquid; adding 200 to 300 parts of drinking water into the filter residues, heating, boiling for 20 to 30min, filtering, removing filtering residues, and mixing the obtained medicine liquid and the medicine liquid after primary boiling. A use method of the Chinese herbal medicine is characterized in that 12L of medicine liquid is sprayed in every 627m<3> of area, and the medicine liquid is sprayed once each day, and is continuously used for 2 to 3 days. The Chinese herbal medicine preparation has the advantages that the Chinese herbal medicine preparation is used for preventing and controlling the insects in aquatic culture, such as fish parasites, and the parasite bodies can be paralysed by the Chinese berry base and tannin, be strongly and lastingly shrunk, and die; the nerves of the parasites can be poisoned by the Chinaberry barks and fruits; the functions of inhibiting, repelling and killing the insects are realized; the effect is quickly released, and is quickly taken, so as to quickly solve the problem of infection of fish diseases.

The invention belongs to the technical field of medicine preparation, and discloses a traditional Chinese medicine compound for treating prostatitis and a preparation method thereof. The traditional Chinese medicine compound is prepared from, by mass, 5-10 g of peach kernel particles, 5-10 g of safflower particles, 10-15 g of dandelion particles, 10-15 g of oldenlandia diffusa particles, 10-15 g of radix cyathulae particles, 10-15 g of fried cowherb seed particles, 10-15 g of caulis clematidis armandii particles, 10-15 g of cortex phellodendri particles, 10-15 g of rhizoma smilacis glabrae particles, 10-15 g of vinegar-processed corydalis tuber particles, 10-15 g of rhizoma atractylodis particles and 10-15 g of bran-fried fructus aurantii particles. The traditional Chinese medicine compound can clear heat and promote diuresis, treat stranguria and detoxify, activate blood circulation to dissipate stasis, and regulate qi to alleviate pain, has definite curative effect in treatment of spermatozoa, warm heat and blood stasis syndrome, seminal vesiculitis, prostatitis and the like, and has the advantages of reasonable compatibility, convenient application, synergistic effect of the components to enhance the drug effect, no pain of patients after administration, fast effectiveness, and short course of treatment; and the preparation method is simple, feasible, rapid and convenient.

The invention discloses an individually taken warfarin sodium orally disintegrating tablet prepared in the manner of 3D printing. The orally disintegrating tablet is mainly prepared from the following materials by weight percent based on a 3D printing technique: 1-10% of warfarin sodium, 90-99% of filler, 0.1-1.0% of silica gel powder and 0-2% of corrigent, wherein the sum of the weight percent of all the components is equal to 100%. The invention also discloses a preparation method for the warfarin sodium orally disintegrating tablet. The warfarin sodium orally disintegrating tablet provided by the invention has high drug release speed. Under the condition of same prescription and technological parameters, the content of the tablet is confirmed on the basis of the printing layer number considered as variable, i.e., the tablet dosage can be individually designed in the manner of changing the printing layer number, the dosage suitable for the patient can be custom-made according to the individual difference of the patient and the individual drug dosage and accurate therapy can be realized, so that the number of the tablets taken by the patient can be reduced or the step of cutting the tablet by the pharmacist can be reduced, the pharmaceutical preparation can exert the maximum curative effect and the toxic side effect of the drug can be reduced to the minimum.

The invention relates to a drug-loaded polyvinyl alcohol microsphere and a preparation method thereof. The polyvinyl alcohol microsphere is prepared from a cellulose acetate butyrate solution, a macro-molecular monomer solution, acrylamide-2-methylpro panesulfonic scid sodium salt solution, potassium persulfate and the like. The polyvinyl alcohol microsphere has the characteristics of high drug absorptive amount, high drug release speed, high roundness and good dispersity of microsphere appearance and small and uniform grain size distribution.