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Method for rapidly detecting sulfur dioxide in wine on-site
ActiveCN108444995AImprove Sensing PerformanceEfficient separationMaterial analysis by observing effect on chemical indicatorRaman scatteringPhosphateSpectrometer
The invention discloses a method for rapidly detecting sulfur dioxide in wine on-site. The method comprises the following steps: (1) after placing a reduced graphene solution, 4-mercaptopyridine and agold nano-rod in a PBS (Phosphate Buffer solution) at room temperature, centrifuging and washing to obtain AuNRs / rGO-MPy; (2) filtering the AuNRs / rGO-MPy through an Anodisc filtering membrane to obtain an AuNRs / rGO-MPy filtering membrane; combining a Karl-Fisher reagent to construct a headspace sampling / paper-based analysis device; detecting sulfur dioxide by utilizing an ultraviolet spectrophotometer and a portable Raman spectrometer. The method disclosed by the invention has the advantages of simplicity and portability in operation, relatively rapid response, high selectivity and good sensitivity; a dual-sensing detection mode can realize optimal sensing performance of sulfur dioxide in a complicated matrix sample and the risks of false positive and false negative are reduced. Detectionlimits are as follows: a colorimetric method: 5.0mu M; an ultraviolet-visible spectrophotometry: 1.45mu M; SERS (Surface Enhanced Raman Scattering): 0.086mu M.
Owner:SHANGHAI INST OF TECH
Method for simultaneously detecting sunset yellow and malachite green in aquatic product
InactiveCN107064105AEliminate distractionsHigh detection sensitivityPreparing sample for investigationRaman scatteringSunset yellowSeed crystal
The invention discloses a method for simultaneously detecting sunset yellow and malachite green in an aquatic product. The method comprises the following steps: (1) preparing a reduced graphene (RGO) nano material by virtue of a hydrothermal method; (2) synthesizing a gold nano rod (GNRs) by virtue of a seed crystal growth method; (3) respectively adsorbing RGO, GNRs, SY and MG in the solution on a screen printing electrode by adopting an electrochemical concentrating method; and (4) detecting a Raman spectral signal of a substance on the surface of the screen printing electrode, so that the SY and MG in the aquatic product can be qualitatively and quantitatively analyzed and detected. By adopting the electrochemical enrichment-SERS detection technology, the method not only has the characteristics of rapidness in analysis, high sensitivity, less consumption of samples, wide application range, simplicity in operation, convenience in carrying and the like, but also has excellent selectivity; and moreover, marking, separation and purification is needed, the sunset yellow and the malachite green in the aquatic product can be simultaneously analyzed and detected, and the detection limit is low.
Owner:SHANGHAI APPLIED TECHNOLOGIES COLLEGE
Gel material for rapid detection of pesticide and preparation method and application thereof
ActiveCN110208242ASimple and fast operationLow costPreparing sample for investigationRaman scatteringSmall samplePesticide residue
The invention relates to a gel material for rapid detection of a pesticide and preparation and application thereof. The preparation comprises the following steps of: (1) preparing PVA pellets; (2) assembling AgNPs on the surfaces of the PVA pellets to form an SERS (Surface Enhanced Raman Scattering) detection substrate; (3) modifying mercaptoethylamine and mercaptopropionic acid on the surfaces ofthe PVA@Ag pellets; (4) selectively absorbing positive and negative charge probe or pesticide molecules to the PVA@Ag surfaces by utilizing the electrostatic interaction; and (5) detecting the live probe molecules or pesticide absorbed to the PVA@Ag surfaces by utilizing a portable Raman spectrometer so as to implement qualitative and quantitative analysis detection on pesticide residues in aquatic products. Compared to the prior art, the PVA@Ag composite material obtained by the preparation disclosed by the invention has the excellent surface enhanced Raman activity, not only has the characteristics of rapid analysis, high sensitivity, small sample use amount, wide application range, simplicity and convenience for operation, convenience for carrying and the like, but also has selectivity, and does not need to be marked and subjected to separation purification.
Owner:SHANGHAI INST OF TECH
Synthesization method of stable isotope labeling beta receptor agonist
InactiveCN106543012AAtom utilization is highSimple process routeCarbamic acid derivatives preparationCarboxylic acid nitrile preparationStable Isotope LabelingBenzene
The invention relates to a synthesization method of a stable isotope labeling beta receptor agonist. Through the organic synthesization method, stable isotope labeling tert-butylamine serves as a labeling precursor and reacts with a bromo-phenethyl alcohol compound in a microwave condition to generate the stable isotope labeling beta receptor agonist. Compared with the prior art, the synthesization method of the stable isotope labeling beta receptor agonist is simple, safe and reliable, and the product reaches 99% or above in chemical purity and isotope abundance after being simply separated and purified, and can fully meet requirements of beta receptor agonist detection of illegal additives in the food safety field.
Owner:SHANGHAI RES INST OF CHEM IND
Synthetic method of stable isotope labeled aminophenylsulfone
ActiveCN104447442AAtom utilization is highSimple process routeOrganic compound preparationIsotope introduction to organic compoundsStable Isotope LabelingSulfur drug
The invention relates to a synthetic method of stable isotope labeled aminophenylsulfone. The method comprises the following steps: by taking stable isotope labeled p-nitro halogeno benzene as a raw material, carrying out nucleophilic substitution to generate stable isotope labeled 4, 4'-dinitro phenyl sulfide; oxidizing to obtain stable isotope labeled 4, 4'-dinitro diphenyl sulfone; and finally carrying out reaction with a reducing agent to obtain the stable isotope labeled aminophenylsulfone. Compared with the prior art, according to the stable isotope labeled aminophenylsulfone prepared by the invention simply separated and purified, the chemical purity reaches over 99% and the isotope abundance is 99%, so that the demand of aminophenylsulfone detection of forbidden sulfonamides in the field of food safety can be fully satisfied.
Owner:SHANGHAI RES INST OF CHEM IND
Stable isotope labeling Clenproperol compound and synthesis method thereof
InactiveCN105968021AAtom utilization is highSimple process routeOrganic compound preparationOrganic chemistry methodsM-aminoacetophenoneStable Isotope Labeling
The invention relates to a stable isotope labeling Clenproperol compound and a synthesis method thereof. The method comprises the following steps of (1) using stable isotope labeling 2,6-dichloroaniline as raw materials to generate stable isotope labeling 3,5-dichloro-4-aminoacetophenone through Friedel-Crafts acyl reaction; (2) performing bromination on the stable isotope labeling 3,5-dichloro-4-aminoacetophenone to obtain stable isotope labeling 3,5-dichloro-4-amino-alpha-bromo acetophenone; (3) enabling the stable isotope labeling 3,5-dichloro-4-amino-alpha-bromo acetophenone and isopropylamine to take a reaction for obtaining stable isotope labeling 1-(4-amino-3,5-dichlone)-2-isopropyl amino ethyl ketone; (4) enabling the stable isotope labeling 1-(4-amino-3,5-dichlone)-2-isopropyl amino ethyl ketone and a reducing agent to take a reaction to generate stable isotope labeling Clenproperol. The stable isotope labeling Clenproperol compound and the synthesis method have the advantages that the process route is simple; the synthesis is easy; the stable isotope atom utilization rate is high; the obtained product can be easily separated and purified; the chemical purity and the fractional isotopic abudance are 99 percent or higher; the trace detection requirements in the food safety field can be sufficiently met.
Owner:SHANGHAI RES INST OF CHEM IND
Method for rapid detection of dimehypo and simazine in tea on site
InactiveCN108645838AQuick checkHigh detection sensitivityRaman scatteringSmall sampleAmmonium hydroxide
The invention discloses a method for rapid detection of dimehypo and simazine in a tea on site. The method comprises (1) preparing a silver-ammonia solution, (2) constructing a PAD-based analysis device, (3) preparing a silver nanoparticle (Ag NPs) paper chip by a silver mirror reaction, (4) wiping the surfaces of dimehypo and simazine samples through the paper chip, and (5) detecting the paper chip through a portable Raman spectrometer to obtain SERS spectrums of the samples and comparing the spectrums of dimehypo and simazine solids to realize qualitative and quantitative detection. Comparedwith the prior art, the method has the characteristics of rapid analysis, high sensitivity, small sample consumption, wide application range, simple operation and convenient carrying, can realize analysis and detection of insecticidal dimehypo and simazine in a tea and has detection limits of 1.2*10<-10>moL / L and 1.0*10<-9>moL / L respective to dimehypo and simazine.
Owner:SHANGHAI INST OF TECH
Stable isotope tag R-clorprenaline and preparation method thereof
InactiveCN108911995AAtom utilization is highSimple process routeOrganic compound preparationOrganic chemistry methodsStable Isotope LabelingVeterinary Drugs
The invention relates to a stable isotope tag R-clorprenaline and a preparation method thereof. The preparation method comprises the following steps: utilizing an organic synthesis method, taking a stable isotope tag chlorobenzene as a raw material and carrying out riedel-Crafts reaction to generate a stable isotope tag chloroacetophenone; carrying out bromination to obtain a stable isotope tag alpha-bromochloroacetophenone; then carrying out one-pot reaction on the stable isotope tag alpha-bromochloroacetophenone, a stable isotope tag isopropylamine and a reducing agent to obtain the stable isotope tag R-clorprenaline. Compared with the prior art, the stable isotope tag R-clorprenaline prepared by the preparation method has the advantages that the chemical purity reaches 99 percent or more and the isotope abundance is 99 percent or more; the stable isotope tag R-clorprenaline can be used for researching a metabolic mechanism of a medicine clorprenaline and detecting the residue of a prohibited veterinary drug clorprenaline in the field of food safety.
Owner:SHANGHAI RES INST OF CHEM IND +1
Rapid field detection method for amoxicillin antibiotics in water
The invention discloses a rapid field detection method for amoxicillin antibiotics in water. The method comprises the following steps: (1) synthesizing a copper metal organic framework Cu-MOFs on thesurface of a screen-printed electrode by an electrochemical method; (2) synthesizing an Ag / Cu-BTC composite nanometer material on the surface of the Cu-MOFs by virtue of an in-situ growth method; (3)enriching amoxicillin antibiotics in to-be-detected water on the Ag / Cu-BTC; and (4) detecting the enriched amoxicillin by utilizing a portable Raman spectrometer, and performing qualitative and quantitative analytical detection on the amoxicillin in the to-be-detected water. The method disclosed by the invention has the characteristics of being rapid in analysis, high in sensitivity, small in sample usage amount, wide in application range, simple and convenient to operate, convenient to carry and the like; and the SERS (Surface Enhanced Raman Scattering) substrate prepared by the method disclosed by the invention has controllable morphology and many SERS active hot spots, can realize analytical detection of the amoxicillin antibiotics in the water, and has a detection limit of 1.8*10<-10>M.
Owner:SHANGHAI INST OF TECH
Method for detecting kanamycin sulfate by double-signal enhanced surface enhanced Raman spectroscopy
ActiveCN112710649AMeet the needs of trace detectionAchieve the effect of double enhancing Raman signalRaman scatteringAptamerGold nanorod
The invention discloses a method for detecting kanamycin sulfate by double-signal enhanced surface enhanced Raman spectroscopy, and belongs to the technical field of food safety detection. In the invention, gold nanorod with a controllable surface plasma resonance peak is used as a Raman substrate, and a cascade oxidation-reduction reaction catalyzed by metal-doped carbon quantum dots and a switching structure controlled by a nucleic acid aptamer are combined to establish a kanamycin sulfate detection system with double enhanced Raman signals, so that the sensitivity of detecting kanamycin sulfate is further improved. The method is low in detection limit, good in specificity, simple, convenient and rapid, and suitable for ultra-sensitive detection of kanamycin sulfate in food.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
Stable isotopic labeled 2-isopropylthioxanthone and synthetic method thereof
ActiveCN105085470ASimple process routeEasy to synthesizeOrganic chemistry methodsGrignard reagentSynthesis methods
The invention relates to stable isotopic labeled 2-isopropylthioxanthone and a synthetic method thereof. The stable isotopic labeled 2-isopropylthioxanthone is 2-isopropylthioxanthone labeled by D or 13C. The synthetic method comprises the following steps of using benzene and acetone which are labeled by stable isotopic D or 13C as raw materials; reacting the benzene and the acetone with magnesium to obtain Grignard reagent after benzene bromination; performing reduction and hydroxide radical bromination on the acetone to obtain 2-bromic propane; performing Grignard reaction to obtain isopropyl benzene; reacting the isopropyl benzene with dithio-salicylic acid; and synthesizing to obtain the 2-isopropylthioxanthone labeled by the stable isotopic D or 13C. Compared with the prior art, the stable isotopic labeled 2-isopropylthioxanthone has the advantages that a process route is simple, the 2-isopropylthioxanthone is easy to synthesize, products are easy to separate and purify, the chemical purity of the products is above 99.0%, isotope abundance is above 98.0% atom, requirements of trace detection in the field of food safety can be met fully, and economical efficiency and using value are excellent.
Owner:SHANGHAI RES INST OF CHEM IND
Stable isotope-labeled alpha-lactalbumin characteristic peptide segment synthetic method
InactiveCN106916219AAtom utilization is highSimple process routeAlbumin peptidesPeptide preparation methodsStable Isotope LabelingDipeptide
The invention relates to a stable isotope-labeled alpha-lactalbumin characteristic peptide segment synthetic method. According to the invention, a liquid-phase polypeptide synthesis method is used, stable isotope-labeled or non-labeled valine is taken as an initial raw material, the initial raw material and Fmoc-protected non-labeled or labeled glycine are subjected to synthesis to obtain dipeptides under effect of a condensing agent, a protective group Fmoc is removed, the material and Fmoc-protected non-labeled or labeled isoleucine are subjected to synthesis to obtain tripeptides under effect of the condensing agent, the tripeptides is reacted with the Fmoc-protected non-labeled or labeled asparagines, tyrosine, tryptophan, leucine, alanine, histidine and Cbz-protected non-labeled or labeled lysine, and finally the stable isotope-labeled alpha-lactalbumin characteristic peptide segment VGINYWLAHK is generated. The chemical purity of the product can reach 99% and above, the isotope abundance is 99% and above, and the product can satisfy the detection requirement of the allergen alpha-lactalbumin in food.
Owner:SHANGHAI RES INST OF CHEM IND
Synthetic method of stable isotope deuterium-labeled alpha-amino acid
InactiveCN108299281ASimple process routeShort reaction timeIsotope introduction to heterocyclic compoundsOrganic compound preparationHydrolysisSodium salt
The invention relates to a synthetic method of stable isotope deuterium-labeled alpha-amino acid. According to the method, one or more deuterium-labeled halides are taken as labeled precursors and subjected to a reaction with phthalimide dimethyl malonate sodium salt, one or more deuterium-substituted phthalimide dimethyl malonate is obtained, and after hydrolysis, stable isotope deuterium-labeledalpha-amino acid is obtained. Compared with the prior art, the synthetic method is simple, safe and reliable, chemical purity of a product after simple separation and purification reaches 99% or higher, isotope abundance is 99% or higher, and the method can be applied to fields of protein metabolism tracing, food safety testing and the like.
Owner:SHANGHAI RES INST OF CHEM IND
A kind of on-site rapid detection method of trichlorfon and simazine in seawater
The invention discloses a field rapid detection method for trichlorfon and simazine in seawater. It includes the following steps: (1) synthesizing gold nanorods by seed crystal method; (2) adding L-cysteine to the gold nanorod solution to obtain L-cysteine-modified gold nanorod materials; (3) Synthesis of gold nanospheres by hydrothermal method; (4) adding p-mercaptoaniline to gold nanospheres to obtain gold nanosphere composites modified by p-mercaptoaniline; (5) gold nanorod materials modified by L-cysteine Mix with the gold nanosphere composite material modified by p-mercaptoaniline, and obtain the gold nanorod and gold nanosphere composite material through the action of peptide bond, as the SERS active substrate; (6) use the Raman spectrometer to detect trichlorfon and simazine, thereby Qualitative and quantitative analysis and detection of trichlorfon and simazine in seawater. The invention has the characteristics of rapid analysis, high sensitivity, less sample consumption, wide application range, simple operation, convenient portability and the like.
Owner:SHANGHAI INST OF TECH
A kind of preparation method of stable isotope reagent sodium borodeuteride
ActiveCN105502292BAvoid abundance dilutionMeet the needs of trace detectionMonoborane/diborane hydridesDeuteriumInorganic chemistry
The invention relates to a preparation method for a stable isotope reagent sodium borodeuteride. The method comprises the following steps: (1) pre-treating a boron-containing substance and quartz sand for complete dehydration, loading the boron-containing substance and the quartz sand in a sealed reaction kettle, adding a pretreated active metal from which a surface oxide layer is removed, connecting a deuterium bag to the sealed reaction kettle, performing heating and stirring, and sucking deuterium for reaction until the volume of the deuterium bag is kept unchanged; (2) after reaction is ended, performing cooling to obtain a sodium borodeuteride product. Compared with the prior art, the preparation method has the advantages that a preparation process route is simple, a preparation condition is mild, less waste gas, wastewater and industrial residues are generated by reaction, and moreover, the prepared sodium borodeuteride has purity capable of reaching 99 percent or above, abundance of 99.9atom% or above and the like.
Owner:SHANGHAI RES INST OF CHEM IND
A kind of stable isotope labeling basic tender yellow o and its synthesis method
ActiveCN104945277BSimple process routeEasy to synthesizeIsotope introduction to organic compoundsAzomethine dyesStable Isotope LabelingDimethylaniline N-oxide
The present invention relates to a stable isotope-marked basic tender yellow O and a synthesis method thereof. Said stable isotope marked basic tender yellow O is basic tender yellow O marked with D or 15N or 13C. During preparation, the stable isotope D or 15N or 13C-labeled methanol and aniline are used as raw materials to synthesize stable isotope D or 15N or 13C-labeled N,N-dimethylaniline precursors, which are then condensed, sulfurized and ammoniated to make stable isotope D or 15N or 13C-labeled bases Sexually bright yellow O. Compared with the prior art, the method of the invention has the advantages of simple process route, easy synthesis, easy separation and purification of products, chemical purity of products of more than 99.0%, isotopic abundance of more than 98.0% atom, which can fully meet the requirements of trace detection in the field of food safety. The economy and use value are good, and it has a good promotion prospect.
Owner:SHANGHAI RES INST OF CHEM IND
Method for detecting dibutyl phthalate through fluorescence ratio method based on dual-emission carbon quantum dot marked nucleic acid aptamer
ActiveCN110849859AHigh sensitivity and selectivityQuick screeningFluorescence/phosphorescenceDi n butyl phthalateRapid detection
The invention discloses a method for detecting dibutyl phthalate through a fluorescence ratio method based on dual-emission carbon quantum dot marked nucleic acid aptamer. Sensitive detection of dibutyl phthalate is realized by taking dual-emission carbon quantum dots as a marker and combining with an aminated nucleic acid aptamer specifically recognizing dibutyl phthalate; the method is low in detection limit, high in specificity, stable in fluorescent performance and suitable for ultrasensitive quick detection of dibutyl phthalate in food.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
A method for the detection of dibutyl phthalate by fluorescence ratio method based on double-emitting carbon quantum dots-labeled nucleic acid aptamers
ActiveCN110849859BAvoid concentration changesQuick screeningFluorescence/phosphorescenceAptamerFluorescence ratio
The invention discloses a method for detecting dibutyl phthalate through a fluorescence ratio method based on dual-emission carbon quantum dot marked nucleic acid aptamer. Sensitive detection of dibutyl phthalate is realized by taking dual-emission carbon quantum dots as a marker and combining with an aminated nucleic acid aptamer specifically recognizing dibutyl phthalate; the method is low in detection limit, high in specificity, stable in fluorescent performance and suitable for ultrasensitive quick detection of dibutyl phthalate in food.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
A method for the detection of kanamycin sulfate by surface-enhanced Raman spectroscopy with dual signal enhancement
ActiveCN112710649BMeet the needs of trace detectionAchieve the effect of double enhancing Raman signalRaman scatteringAptamerSurface-enhanced Raman spectroscopy
The invention discloses a method for detecting kanamycin sulfate by double-signal-enhanced surface-enhanced Raman spectroscopy, which belongs to the technical field of food safety detection. The present invention uses gold nanorods with controllable surface plasmon resonance peaks as the Raman substrate, and combines the cascaded redox reaction catalyzed by metal-doped carbon quantum dots and the switch structure controlled by nucleic acid aptamers to establish a dual enhanced Raman signal The advanced kanamycin sulfate detection system further improves the sensitivity of detecting kanamycin sulfate. The invention has low detection limit, good specificity, is simple and fast, and is suitable for ultrasensitive detection of kanamycin sulfate in food.
Owner:SHANDONG AGRICULTURAL UNIVERSITY
A kind of stable isotope labeling 2-isopropylthioxanthone and its synthesis method
ActiveCN105085470BSimple process routeEasy to synthesizeOrganic chemistry methodsGrignard reagentSalicylic acid
Owner:SHANGHAI RES INST OF CHEM IND
A kind of synthesis method of stable isotope labeling prohibited pigment
The invention relates to a synthesis method of stable isotope-labeled prohibited pigments. The method uses stable isotope D or 13C-labeled bromobenzene to synthesize stable isotope D- or 13C-labeled intermediate sodium p-aminobenzenesulfonate through ammoniation and sulfonation , or use bromobenzene as a raw material, and ammonate and sulfonate the stable isotope 15N-labeled intermediate sodium p-aminobenzenesulfonate through ammoniation and sulfonation with a stable isotope 15N-labeled ammoniation reagent, and then undergo diazotization and coupling to obtain stable synthesis Prohibited pigments labeled with isotope D or 15N or 13C. Compared with the prior art, the process route of the present invention is simple, easy to synthesize, easy to separate and purify the product, the chemical purity of the product is above 99.0%, and the isotope abundance is above 98.0% atom, which can fully meet the needs of trace detection in the field of food safety. It has good economy and use value.
Owner:SHANGHAI RES INST OF CHEM IND
an electron ionization source
ActiveCN104599933BImprove exit efficiencyHigh sensitivitySamples introduction/extractionIon sources/gunsElectron sourceElectron ionization
The invention provides an electron ionization source, including an electron source, a repulsion electrode and an ion lens, and further including a first cylindrical component, an annular component and a second cylindrical component, wherein the electron source is arranged at the side part of the first cylindrical component, the repulsion electrode is arranged in the first cylindrical component with two open ends, the annular component is arranged on one side of the first cylindrical component, one side, far away from the first cylindrical component, of the annular component is provided with an outlet, and the inner diameter of the hollow inner part of the annular component is gradually reduced along the emitting direction of ions, the second cylindrical component is arranged in the outlet, and the iron lens is arranged on one side of the second cylindrical component along the emitting direction of the ions. The electron ionization source has the advantage of being high in ion emitting efficiency.
Owner:FOCUSED PHOTONICS +1
A kind of synthetic method of stable isotope labeling beta receptor agonist compound
ActiveCN104478740BEasy to synthesizeSimple process routeCarbamic acid derivatives preparationCarboxylic acid nitrile preparationStable Isotope LabelingTert-Butylamine
The invention relates to a synthesis method of a stable isotope-labeled beta receptor agonist type compound. The synthesis method comprises the following steps: (1) by taking stable isotope-labeled methanol as a raw material, reacting with acetone or stable isotope-labeled acetone, and ammonifying to obtain stable isotope-labeled tert-butylamine; and (2) by taking a bromoketone type compound as a precursor of the beta receptor agonist type compound, reacting with stable isotope-labeled tert-butylamine to prepare the stable isotope-labeled beta receptor agonist type compound. Compared with the prior art, the method for preparing the stable isotope-labeled beta receptor agonist, provided by the invention, is simple, safe and reliable, the chemical purity of the product after separation and purification is above 99.0%, the isotopic abundance is above 98.0% atom, and the product can fully meet the requirements of residual detection in the field of food safety.
Owner:SHANGHAI RES INST OF CHEM IND
A kind of on-the-spot rapid detection method of sulfur dioxide in wine
ActiveCN108444995BImprove Sensing PerformanceEfficient separationMaterial analysis by observing effect on chemical indicatorRaman scatteringOptical spectrometerPhysical chemistry
The invention discloses a method for rapidly detecting sulfur dioxide in wine on-site. The method comprises the following steps: (1) after placing a reduced graphene solution, 4-mercaptopyridine and agold nano-rod in a PBS (Phosphate Buffer solution) at room temperature, centrifuging and washing to obtain AuNRs / rGO-MPy; (2) filtering the AuNRs / rGO-MPy through an Anodisc filtering membrane to obtain an AuNRs / rGO-MPy filtering membrane; combining a Karl-Fisher reagent to construct a headspace sampling / paper-based analysis device; detecting sulfur dioxide by utilizing an ultraviolet spectrophotometer and a portable Raman spectrometer. The method disclosed by the invention has the advantages of simplicity and portability in operation, relatively rapid response, high selectivity and good sensitivity; a dual-sensing detection mode can realize optimal sensing performance of sulfur dioxide in a complicated matrix sample and the risks of false positive and false negative are reduced. Detectionlimits are as follows: a colorimetric method: 5.0mu M; an ultraviolet-visible spectrophotometry: 1.45mu M; SERS (Surface Enhanced Raman Scattering): 0.086mu M.
Owner:SHANGHAI INST OF TECH
Minitype optical derivatization device for aflatoxin and sulfonamides
ActiveCN109387576AReduce Derivative Pool VolumeReduce stretchingComponent separationFluorescence/phosphorescencePhysicsPost column derivatization
The invention provides a minitype optical derivatization device for aflatoxin and sulfonamides. The minitype optical derivatization device comprises an ultraviolet LED light source with an excitationwavelength in a range of 280 to 370 nm, and adopts an ultraviolet-permeable pipe with a small internal diameter as a derivation reaction pool, wherein a derivatization reaction pipe is spirally woundon the inner wall of alight-reflective bowl in a single layer manner, and has an internal diameter of 0.10 to 0.35 mm and a length of 17 to 30 cm; and the derivation reaction pool has a volume of 7 to15 [mu]L. The optical derivatization device provided by the invention increases the fluorescence intensity of aflatoxin B1 by 5 times; and the optical derivatization device meets the requirements ofliquid chromatography post-column derivatization and flow injection analysis derivatization, and is used for analyzing trace aflatoxin and sulfonamides in a sample through combined application of high-performance liquid chromatography (HPLC) and ultra-high-pressure liquid chromatography (UPLC).
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
A method for on-site rapid detection of amoxicillin antibiotics in water
ActiveCN108982466BShape is easy to controlAchieve reuseRaman scatteringMetal-organic frameworkMicrobiology
Owner:SHANGHAI INST OF TECH
Synthesizing method for prohibited pigment labeled by stable isotope
The invention relates to a synthesizing method for a prohibited pigment labeled by a stable isotope. According to the synthesizing method, bromobenzene labeled by a stable isotope D or 13C is aminated and sulfonated to synthesize an intermediate sodium sulfanilate labeled by the stable isotope D or 13C, or the bromobenzene is taken as the raw materials and then aminated and sulfonated with an ammoniation reagent labeled by a stable isotope 15 N to synthesize the intermediate sodium sulfanilate labeled by the stable isotope 15N, and then diazotizing and coupling are performed to synthesize the prohibited pigment labeled by the stable isotope D or 15N or 13C. Compared with the prior art, the synthesizing method has the advantages that the process route is simple, the prohibited pigment labeled by the stable isotope is easy to synthesize, the product is easy to separate and purify, the chemical purity of the product is more than 99.0 percent, the isotope abundance is more than 98.0 percent, the requirements of trace detection in the field of food safety can be fully met, and the good economical efficiency and use value are achieved.
Owner:SHANGHAI RES INST OF CHEM IND
A miniature photoderivatizer for aflatoxins and sulfonamides
ActiveCN109387576BImprove overall lifespanIncrease power consumptionComponent separationFluorescence/phosphorescencePostcolumn derivatizationUltraviolet lights
The invention provides a miniature light derivatizer for aflatoxin and sulfa drugs. It includes a UV LED light source, the excitation wavelength of which is between 280 and 370nm, and uses a thin inner diameter tube transparent to ultraviolet light as the derivation reaction pool. The diameter is 0.10-0.35 mm, the length is 17-30 cm, and the volume of the derivation pool is 7-15 μL. The optical derivatizer of the present invention increases the fluorescence intensity of aflatoxin B1 by 5 times; the derivatizer is used for liquid chromatography post-column derivatization and flow injection analysis derivatization needs, including high performance liquid chromatography (HPLC) and ultra-high pressure liquid Trace aflatoxins and sulfonamides in samples were analyzed by UPLC.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Method for on-site rapid detection of sulfur dioxide in tremella fuciformis and sampling paper chip
The invention relates to a method for on-site rapid detection of sulfur dioxide in tremella fuciformis. The method comprises the following steps: S1, wiping the surface of a tremella fuciformis sampleto be tested through a benzaldehyde-fuchsin compound paper chip to obtain a sampled paper chip; S2, using a portable Raman spectrometer for detecting the sampled paper chip, the excitation wavelengthduring detection being 785 nm, and obtaining an SERS spectrum of the sample; and S3, carrying out characteristic peak comparison on the SERS spectrum, carrying out qualitative detection on sulfur dioxide, and carrying out quantitative detection on sulfur dioxide according to a linear relationship between the concentration of sulfur dioxide and Raman signal intensity. Compared with the prior art,the method has the characteristics of being rapid in analysis, high in sensitivity, small in sample dosage, easy and convenient to operate, convenient to carry and the like, SO2 in tremella fuciformiscan be analyzed and detected, and the detection limit is 1.2 * 10<-8> moL / L. Physical friction sampling is adopted in the sampling process, the detection precision and the detection efficiency are remarkably improved, and the requirement for trace detection is met.
Owner:SHANGHAI INST OF TECH
A kind of synthetic method of stable isotope labeling dapsone
ActiveCN104447442BAtom utilization is highSimple process routeOrganic compound preparationIsotope introduction to organic compoundsStable Isotope LabelingSulfur drug
The invention relates to a synthetic method of stable isotope labeled aminophenylsulfone. The method comprises the following steps: by taking stable isotope labeled p-nitro halogeno benzene as a raw material, carrying out nucleophilic substitution to generate stable isotope labeled 4, 4'-dinitro phenyl sulfide; oxidizing to obtain stable isotope labeled 4, 4'-dinitro diphenyl sulfone; and finally carrying out reaction with a reducing agent to obtain the stable isotope labeled aminophenylsulfone. Compared with the prior art, according to the stable isotope labeled aminophenylsulfone prepared by the invention simply separated and purified, the chemical purity reaches over 99% and the isotope abundance is 99%, so that the demand of aminophenylsulfone detection of forbidden sulfonamides in the field of food safety can be fully satisfied.
Owner:SHANGHAI RES INST OF CHEM IND
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