47results about How to "Rapid symptoms" patented technology

The present invention is directed generally to a TLR8 agonist VTX-378, for use in the treatment or prevention of allergic diseases, including allergic rhinitis.

The invention relates to compositions for use in purgatives, to purgatives comprising such compositions, and to methods for inducing purgation of the colon. The composition may comprise at least one water-soluble sodium salt; at least one water-soluble minimally degradable sugar in an amount, by weight, of from about 1 to about 3 times the weight of sodium ions in said composition; at least one water-soluble potassium salt in an amount, by weight, of from about 0.05 to about 1 time the weight of said sodium salt in said composition; and at least one water-soluble magnesium salt, wherein the weight of magnesium ions in said composition is from 0.1 to about 10 times the weight of sodium ions in said composition.

Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.

The invention discloses a medicament for treating lymphoma. The medicament comprises the following raw materials: codonopsis pilosula, astragalus, glossy privet fruit, panax root, asparagus, glabrous greenbrier rhizome, kelp, largehead atractylodes rhizome, Indian buead, costustoot, raw chicken's gizzardskin, pseudoginseng root, clematis root, zedoary, common burreed rhizome, liquoric root, buttercup root, pinellia tuber, arisaema cum bile, rhizoma bolbostemmae, spreading hedyotis herb, barbed skullcap herb, honeysuckle flower, baical skullcap root, weeping forsythia, vietnamese sophora root, Indian iphigenia bulb, solanum nigrum L, bittersweet herb, sun euphorbia herb, Indian mockstrawberry herb, toad skin, lily, wall lizard, figwort root, oyster, green tangerine peel, tangerine peel, Chinese sage herb, common selfheal fruit-spike, ground beetle, grub, scorpion, centipede, processed turtle shell, ginseng, paris polyphylla, akebia trifoliata koidz, dandelion, sarcandra glabra, hairyvein agrimonia herb and bud, bezoar, frank incense and myrrh. The medicament is prepared by grinding the pseudoginseng root and the bezoar into powder, encapsuling the powder, and decocting other raw materials by the conventional method. The medicament is prepared from pure Chinese herbal medicines, is safe and nontoxic and can greatly improve the quality of life of cancer patients; and the cost is much lower than that of concurrent chemoradiotherapy and surgical treatment, so that all lymphoma patients can afford the medicament.

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

A pacemaker system comprising apnea detecting means for measuring parameters about respiratory including at least two parameters of the number of apneas per unit time and the period of time during which an apnea continues and detecting an apnea state of a sleeping patient on the basis of the measured parameters, characterized in that when the measured values of the detection parameters measured by the apnea detecting means increase over reference values at which the pacing rate is changed to a preset and stored SAS treating pacing rate, the pacing rate is changed and the pacing mode is changed to an SAS treating pacing mode. The apnea syndrome of the sleeping patient is detected and treated coping with the bradycardia and various problems accompanying the apnea syndrome. The pacing rate and the pacing rate time can be set suitably for the patient without imposing too heavy a burden on the patient depending on the condition of the patient, and consequently the syndrome of the SAS can be treated efficiently and reliably.

Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.

The invention provides a preparation method of a compound Chinese traditional medicine preparation used for treating AIDS; the preparation is prepared into a pill by the following raw materials: rhinoceros horn, royal jelly, pilose antler, ginseng, salvia miltiorrhiza, antelope horn 5, radix codonopsitis, radix adenophorea, brown sugar, honey, Chinese caterpillar fungus, black sesame oil, and so on; a decoction is prepared by the following raw materials: spine date seed, wild chrysanthemum flower, atractylodes rhizome, liquorice, Chinese goldthread, pseudoginseng, fumitory, great burdock achene, bitter orange, fritillaria, polygalae, Chinese cynomorium, and so on; a medicated bath preparation is prepared by the raw materials of radix asparagi, vervain, dendrobe, rehmanniae radix, glossy privet fruit, pagoda flower, dried orange peel, magnolia officinalis, asiatic plantain seed, dodder, oyster, centipede, and so on. The pill and the decoction are taken orally and the bath preparation is heating for external bathing; the unconventional treatment method of taking the improvement of autoimmune function and metabolism as the priority and the external and internal treatment of the decoction as the auxiliary is implemented for treating, relatively ideal curative effect is achieved, the effective rate reaches over 80 percent, and the invention provided a effective new path for the world-wide stubborn ill of AIDS.

The present invention relates to a green juice and polysaccharide flour. The flour is made by agitating and mixing 1000 shares by weight of flour, 3 to 50 shares by weight of green juice powder and 0.03 to 0.067 share by weight of polysaccharide. The flour can be made into various flour products, such as steamed buns, steamed twisted rolls, silver thread rolls, noodles, dumpling wrappers, cakes, etc. The present invention has the advantages that the addition of the green juice powder makes the flour have nutritious and health-care functions, the addition of the polysaccharide can make the nutrient absorption effect of green juice increased by three times, and the immunity of human bodies can be improved. At present, people pay more attention to food nourishing and food therapy, so the market potential of the flour is infinite.

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I)wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient active binding to the serotonin receptors to provide relief from migraine symptoms within a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.

The invention relates to gel with anti-inflammation, anti-pruritus and sterilization effects, and belongs to the field of medicines. The gel is mainly applied to pediatric pruritic dermatosis, and can be used in different forms such as a therapeutic medicament and / or a sterilizer, a health care product, a sanitary product and the like for adjunctive therapy or for different purposes. The invention provides brand-new gel, wherein the gel is prepared by adding pharmaceutically acceptable minor ingredients into the following raw materials in parts by weight: 10 to 20 parts of lonicera japonica (lonicera confusa), 4 to 12 parts of belvedere fruit, 6 to 14 parts of astragalus mongholicus, 1 to 4 parts of lithospermum purpurocaeruleum, 8 to 16 parts of cortex dictamni, 1 to 4 parts of mint, 0.001 to 2 parts of borneol, 1 to 4 parts of cicada slough, 8 to 16 parts of talc, 1 to 4 parts of licorice and 0.1 to 2 parts of honey. By the gel, the effects of dispelling wind, clearing heat, cooling blood, resolving toxin, removing dampness, relieving itching, removing impurities and protecting skin can be effectively achieved; and the gel is particularly applied to the pediatric pruritic dermatosis such as pediatric papular urticaria, miliaria, dermatitis aestivale, diaper dermatitis and eczema.

The invention discloses a derivant of establishing a rheumatoid arthritis animal model, and preparation and application thereof; the derivant comprises II type collagen, aluminium hydroxide, glacial acetic acid and complete freund adjuvant; the derivant can successfully form the rheumatoid arthritis animal model, can substantially boost immunization reaction, can keep arthritis symptom to last for a longer time, so clinic symptom and pathology change of the animal model can be more close to real rheumatoid arthritis; the preparation method of the derivant is simple in operation, and convenient for promotion and application; the derivant is used for establishing the rheumatoid arthritis animal model, is simple and safe in realization, good in stable reliability, high in molding success rate, and has excellent application prospect.

The invention discloses a bupleurum root oral liquid and its manufacturing method, which relates to a Chinese traditional medicine and its manufacturing method, especially a Chinese traditional medicine for curing wind heat and cold and its manufacturing method. It uses bupeurum root, large-flowered skullcap root, cane sugar as material to produce the medicine with current medicine processing technology. The product is produced according to national traditional medical theory, the product is convenient, quick, and has no toxin and side effects, it can be applied to prevent and cure upper respiratory tract diseases.

The invention discloses a facial palsy rectify patch and a treatment method. The rectify patch consists of medicines and the patches for bearing the medicines. The medicines are made of master medicines and auxiliary medicines. The master medicines comprise the medicines as follows: radix astragali, cassia twig, gambir plant, red peony, salvia miltiorrhiza, szechuan lovage rhizome, kudzuvine root, great burdock achene, earthworm, weeping forsythiae capsule, baical skullcap root, honeysuckle flower, medcinal evodia fruit, zedoary root, turmeric, divaricate saposhnikovia root, magnetite, Bungarus multicinctus, Chinese sage herb, simpleleaf shrub chastetree fruit and paris polyphylla; while the auxiliary medicines comprise one milliliter of laurocapam with a concentration of one percent. The invention can make full use of the Chinese medicine effect and has quick medical effect and obvious efficacy; the medicine is stuck at the joints, channels and collaterals on the surface corresponding to the human body viscera so as to exert a certain positive excitation, so that the nerves can change during the process of energy conversion and information coding; the invention also can activate, enhance, decrease or deactivate some enzymes inside the cell, thereby promoting the body own solution and the recovery ability through the nerves and the internal secretion so as to cure diseases and eliminate symptoms.

The invention discloses a bone hyperplasia plaster, which is prepared from the following raw materials in parts by weight: clematis 10-20, frankincense 2-5, myrrh 2-5, Xu Changqing 10-20, safflower 10 -20, camphor 2-5, borneol 2-5, Chuanwu 5-10, kudzu root 5-10. The invention also discloses a preparation method of the plaster. According to clinical tests, the plaster has the advantages of rapid symptom improvement, high cure rate and low recurrence rate after healing.

Estramustine phosphate is an anti-mitotic chemotherapeutic drug with proven efficacy against cancer. The invention describes methods which potentiate the therapeutic benefit of intravenous estramustine phosphate. The invention provides for intravenous estramustine phosphate to be administered at a high dosage exceeding 1300 mg as a single dose. Efficacious enhancement of estramustine phosphate pharmacokinetics is thereby achieved. Further provided, estramustine phosphate may be intravenously administered for use in combinational regimens with other chemotherapeutic agent. The therapeutic advantages achieved using the intravenous estramustine phosphate formulation are applicable to treatment of a variety of cancers including prostate cancer, breast cancer, lung cancer, colorectal cancer, pancreatic cancer, ovarian cancer, melanoma, and other cancers.

Asthma is an inflammatory disease of the airways in the lungs and bronchial tubes, the lower airway, that impairs breathing, causes wheezing, coughing and excess mucus and phlegm production. Asthma is the source of about one-fourth of all emergency room admissions. Throat lozenges and orally-retained liquids, such as syrups, containing magnesium are used in the invention to rapidly terminate asthma attacks and prevent asthma attacks. Magnesium lozenges and magnesium orally-retained liquids are effective in asthma rescue. Treatment of asthma with orally-retained magnesium, an essential human nutrient, is much safer than treatment by drugs yet they appear as effective as current drugs. An added benefit from magnesium treatment is relaxation. A preferred composition is 100 mg of magnesium from 400 mg magnesium chloride in a 4-gram lozenge. Magnesium lozenges or orally-retained liquids are administered as needed to treat asthma attacks or prevent incipient asthma attacks. Throat lozenges and orally-retained liquids of any pharmaceutically acceptable composition containing any pharmaceutically acceptable compound of magnesium are disclosed and claimed as effective in the treatment and prevention of asthma.

The invention discloses a method for preparing an anti-malarial medicament with reversal of medicament resistance and multi-target effect, which comprises the process flow of performing stock preparation, preparing water-soluble Chinese medicament inclusion microspheres, preparing alcohol-soluble Chinese medicament inclusion microspheres, and preparing water-soluble chemical medicament inclusion microspheres. The method takes beta-cyclodextrin as a framework material, and includes a nano-magnetic biomaterial (carrier material) and a pharmaceutical composition; and the medicament-loaded nano-magnetic microspheres can be quickly combined with target cells, penetrate target cell membranes to enter the cells, realize the transmembrane transport of medicament molecules, inhibit the gene expression and amplification of the target cells to ensure that the target cells degenerate, necrotize or apoptosize, and achieve the effect of the reversal of medicament resistance at the same time. An anti-malarial oral preparation interferes the processes of DNA replication and RNA transcription of schizonts of plasmodiums, kills schizonts of erythrocytic phases of the plasmodiums, and effectively kills exoerythrocyte stages of the plasmodiums and gametophytes of the plasmodiums at the same time; and at the same time, the anti-malarial oral preparation achieves the aims of preventing disease causes, and controlling the prevalence and propagation of malaria.

A device / system and a method of treating enlarged prostate and other urologic abnormalities are presented. A combined treatment is performed with several interstitial coagulating probes and an ablating fiber. Tissue vaporization is minimized by the denaturalizing effect of interstitial coagulative fibers. In a single device, multiple delivery systems achieve optimal tissue ablation / coagulation; a non-laser source like microwave energy coagulates tissue and a laser source ablates tissue. Another device comprises two or more laser sources with adjustable wavelengths controllable by physician as to ablative, coagulative, and tissue penetration needs. Continuous, semi-continuous, pulsed wave, or combinations are useful. In another embodiment, optical fiber has a central core for transmitting laser radiation, and a cladding layer about the core that may further transmit other laser radiation of a different or a same wavelength as the core. Fibers may have a side-firing distal end, a radial firing end, or an off-axis firing end. Feedback controls can be used. In general coagulative irradiation can use a radiofrequency or other radiant thermal source.

The invention relates to a medicament for treating tumor, in particular to oral Chinese medicinal herbal tablets for treating tumors, which are used for treating advanced malignant tumor, inhibiting and shrinking tumor, improving appetite and enhancing physical ability, and a preparation method. The oral Chinese medicinal herbal tablets are prepared from the following raw materials: barbed skullcap herb, bittersweet herb, paris polyphylla, vietnamese sophora root, natural indigo, bezoar, lightyellow sophora root, Chinese pulsatilla root, common dysosmatis rhizome and root, ginseng, cordyceps, wild lucid ganoderma, stiff silkworm, garden balsam, pedate pinallia jackinthepulpit rhizome, radix stephaniae tetrandrae, clematis root, root of hibiscus mutabilis L., and hemsleyae sphaerocarpae radix sources. The preparation method of the oral Chinese medicinal herbal tablets comprises the following steps of: weighing the raw materials of the Chinese medicinal herbal tablets for treating moderate and advanced malignant tumor and drying; crushing the dried raw materials to form particles with diameter of more than 800 meshes; adding amylin into raw material particles, uniformly mixing and preparing into tablets; and drying, checking and packaging the tablets to obtain oral Chinese medicinal herbal tablets for treating tumors. The oral Chinese medicinal herbal tablets for treating tumors have the characteristics of shrinking tumor blood capillary, inhibiting the growth of the tumor cells, along with safe use.

An imidazole compound represented by the formula (I), a salt thereof and a compound of the formula (V), which is one of the intermediates thereof. wherein each symbol is as defined in the present specification. The compound of the present invention shows a superior anti-ulcer activity, a gastric acid secretion inhibitory action, a mucosa-protecting action, an anti-Helicobacter pylori action and the like. Since it shows low toxicity, the compound is useful as a pharmaceutical product.

The invention discloses a pharmaceutical composition for treating pharyngitis and laryngitis, which contains Iris tectorum Maxim. extract flavones as the active ingredient, and pharmaceutically acceptable adjuvant or supplementary constituents, wherein the content of the extract flavones is greater than 55% calculated by Tectoridin C22H22O11. The effective constituents being Tectoridin, Tectoridin A, Tectorigenin, and wild Tectorigenin, the four ingredients have synergic action.

The invention relates to an external medicament, and has the function of anti-inflammation, relieving itch, and disinfection, and is mainly used for curing children's pruritic dermatopathy, and can be used as therapeutic medicine or sanitizing agent, health care articles, and sanitary articles for assistant treatment with different forms or aims. The active component of the external medicament which is made from components with the weight proportioning of 10-20 parts of honeysuckle flower, 4-12 parts of broom cypress fruit, 6-14 parts of astragalus root, 1-4 parts of alkanna tinctoria, 8-16 parts of dittany bark, 1-4 parts of peppermint, 0.001-2 parts of borneo camphor, 1-4 parts of cicada skin, 8-16 parts of talcum, 1-4 parts of licorice root, and 0.1-2 parts of bee honey. The function of dispelling wind and removing heat, cooling blood and detoxification, dehumidification and relieving itch, and cleansing dirt and nourishing skin can be effectively played, and the invention is particularly applicable to children's pruritic dermatopathy, and has the advantages of high efficiency, cause and symptom solution, precise curing effect, convenient employment, and can alleviate symptoms quickly, and does not have toxicity, stimulation, and corrosivity and the like.

The invention discloses a pharmaceutical composition for treating pharyngitis and laryngitis, which contains Iris tectorum Maxim. extract flavones as the active ingredient, and pharmaceutically acceptable adjuvant or supplementary constituents, wherein the content of the extract flavones is greater than 55% calculated by Tectoridin C22H22O11. The effective constituents being Tectoridin, Tectoridin A, Tectorigenin, and wild Tectorigenin, the four ingredients have synergic action.

The invention discloses an oral liquid with Cherokee rose toot and spatholobus stem for treating adnexitis, endometritis, and pelvic inflammation. The oral liquid is prepared from root of Fructus Rosae Laevigatae, spatholobus stem, mahonia stem, shiny pricklyash, Moghania philippinensis, green chiretta and cane sugar as raw material through modern Chinese medicine processing techniques.

The invention belongs to the field of traditional Chinese medicines and healthcare foods, and particularly relates to a ganoderma lucidum origin-consolidating composition and medicinal liquor and a preparation method and application thereof. The invention aims at providing a brand new composition for nourishing kidney, tonifying spleen and qi and increasing essence, which takes ganoderma lucidum as a main component and is obtained by matching with multiple traditional Chinese medicines. The composition consists of ganoderma lucidum, hericium erinaceus, fructus lycii, rhizoma polygonati, fructus rubi, oyster, rhizoma dioscoreae, poria cocos, fructus crataegi, fructus hordei germinatus, endothelium corneum gigeriae galli, phyllanthus emblica, herba taraxaci, lophatherum gracile, fructus gardeniae and liquorice. The invention also provides the ganoderma lucidum origin-consolidating medicinal liquor which is prepared by adopting the following steps: adding water into the composition according to a conventional method and decocting; combining and concentrating; and adding white spirit, stevioside and osmanthus fragrans essence and mixing to obtain the medicinal liquor. By direct drinking, the medicinal liquor has the effects of nourishing kidney, tonifying spleen and qi and increasing essence.

The invention discloses an external composition for treating the bone disease and a preparation method of the external composition. The external composition is prepared from the following bulk pharmaceutical chemicals in parts by weight: 18-25 parts of chinese angelica, 8-13 parts of safflower, 14-18 parts of rhizoma chuanxiong, 18-25 parts of drynaria total flavonoids, 18-25 parts of clematis chinensis, 18-25 parts of radix astragali seu hedysari, 18-25 parts of clematis chinensis, 18-25 parts of radix notoginseng, 18-25 parts of corydalis yanhusuo, 3-8 parts of olibanum, 3-8 parts of myrrh,3-8 parts of borneol, 14-18 parts of paniculate swallowwort root, 4-10 parts of camphor, 8-13 parts of radix aconit and 15-20 parts of eucommia ulmoides. The preparation method comprises the steps that after all the bulk pharmaceutical chemicals are mixed uniformly, then soaked for 2-4 h and fried through high heat for 3-5 h, supernatant liquid is taken and concentrated, and base materials are added to make a paste. The external composition for treating the bone disease has the characteristics of pain relieving and swelling, rapid improvement of symptoms, high cure rate and low recurrence rateafter healing for various types of the bone disease caused by wind, cold and wetness.

The invention relates to the field of drug carriers, in particular to a bone-targeted nanoparticle delivery system and a preparation method thereof. The bone-targeted nanoparticle delivery system comprises nanoparticles and bone-targeted functional components. The nanoparticles are monolayer vesicles internally wrapped with pharmaceutical active ingredients, the vesicle membranes of the monolayervesicles are composed of degradable polymers and polyvinyl alcohol, the vesicle membranes are cuttaged with dithiosuccinimide-octyl diacid ester, and the nanoparticles are in conjugated combination with the bone-targeted functional components through the dithiosuccinimide-octyl diacid ester. According to the bone-targeted nanoparticle delivery system, as the monolayer vesicles are wrapped with thepharmaceutical active ingredients, greater drug carrying capacity is achieved, in addition, through detection, stability of vitro release test is good, and drug release is controllable.

The invention discloses a traditional Chinese medicine composition for treating radiation pneumonitis. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: 20-30g of Indian buead, 10-20g of fresh ginger, 10-20g of English walnut seed, 10-20g of dried human placenta, 10-20g of platycodon root, 10-20g of ginseng, 10-20g of Chinese angelica, 10-20g of cassia twig, 10-20g of radix notoginseng, 8-15g of Chinese magnoliavine fruit, 8-12g of herb of christina loosestrife, 8-12g of indigowoad leaf, 8-12g of perilla fruit, 8-12g of malaytea scurfpea fruit, 8-12g of turmeric root-tuber, 8-12g of heartleaf houttuynia herb and 3-5g of cicada slough. All the medicinal materials are excellent in compatibility and reasonable in formula to achieve the effects of clearing away heat and toxic materials, removing blood stasis and dispersing lung, resolving carbuncle and expulsing boil, tonifying the lung and invigorating primordial Qi, warming the spleen and stomach to promote transportation of the spleen, regulating the flow of qi to stop coughing and the like, and has unique advantages in the aspects of improving clinical symptoms of radiation pneumonitis patients, improving the quality of life, prolong the survival time and the like.