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Therapeutic drug for traumatic neural disease (disorder) and/or motor function disorder

A technology for the treatment of motor dysfunction and drugs, which is applied in the field of drugs for the treatment of traumatic neurological disorders and/or motor dysfunction, and can solve problems such as unclear effects

Inactive Publication Date: 2009-02-18
GLYCOSCIENCE LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of IL-12 in spinal cord injury is unclear

Method used

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  • Therapeutic drug for traumatic neural disease (disorder) and/or motor function disorder
  • Therapeutic drug for traumatic neural disease (disorder) and/or motor function disorder
  • Therapeutic drug for traumatic neural disease (disorder) and/or motor function disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0072] Embodiments of the present invention will be explained below with reference to the drawings. However, the present invention is not limited to the Examples set forth below.

[0073] [Materials and methods]

[0074] [Preparation of L4]

[0075] Using the method of Xu et al., as described below, L4 was prepared by degradation of keratan sulfate with cutinase II followed by separation by anion exchange chromatography.

[0076] KS oligosaccharide (L4) was isolated from the degradation product of cutanase II from shark fin keratan sulfate (Biochemical Industry) by performing a series of steps of anion exchange chromatography and gel permeation chromatography. The oligosaccharide was identified by capillary electrophoresis and mass spectrometry (Non-Patent Document 4).

[0077] Capillary electrophoresis was performed using a Quanta 4000 capillary electrophoresis system (Waters) with UV detector. In capillary electrophoresis systems, the sample is loaded on the anode, using...

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PUM

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Abstract

Provided is a therapeutic agent for traumatic neuropathy and / or movement disorder, particularly a therapeutic agent for traumatic neuropathy and / or movement disorder caused by spinal cord injury. It is found that a keratan sulfate oligosaccharide or a derivative thereof has an ameliorative effect on traumatic neuropathy and / or movement disorder caused by spinal cord injury and therefore is useful as a therapeutic agent for traumatic neuropathy and / or movement disorder. Thus, provided is a therapeutic agent for traumatic neuropathy and / or movement disorder, wherein the therapeutic agent comprises an effective amount of a keratan sulfate oligosaccharide or a derivative thereof.

Description

technical field [0001] The present invention relates to a therapeutic drug for traumatic nerve disorder and / or motor dysfunction, in particular to a therapeutic drug for traumatic nerve disorder and / or motor dysfunction caused by spinal cord injury. Background technique [0002] It is reported that Asari et al. have found that L4, keratan sulfate disaccharide shown in the following formula, has an inhibitory effect on the expression of interleukin-12 (IL-12) (Non-Patent Document 1). [0003] Gal(6S)β1-4GlcNAc(6S) [0004] (wherein, Gal represents a galactose residue, GlcNAc represents an N-acetylglucosamine residue, 6S ​​represents that the hydroxyl group at the 6-position is in the form of a 6-O-sulfate ester, and β1-4 represents a β1-4 glycosidic bond.) [0005] IL-12 is known to express at a high level in MRL-1pr / 1pr mice, immortalize T lymphocytes (CD4-CD8-), and swell lymphoid organs (lymph nodes and spleen) (Non-Patent Document 2). In addition, it has been reported t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61K31/737A61P25/00C07H11/00C08B37/00
CPCA61K31/737A61P25/00
Inventor 浅利晃加藤忠彦
Owner GLYCOSCIENCE LAB INC
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