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Drug composition for treating cervical cancer and preparation method thereof

A composition and drug technology, applied in the field of pharmaceutical composition and its preparation, can solve problems such as large trauma, treatment failure, and refractory cure

Active Publication Date: 2012-07-04
DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, it is considered that radiotherapy and surgery are effective methods for the treatment of cervical cancer. However, in many clinical cases with high risk factors, such as advanced cancer, barrel carcinoma, lymph node metastasis or small cell carcinoma, no matter whether surgery or radiotherapy is satisfactory, local recurrence of cervical tumors and Distant metastasis is the main cause of treatment failure. Even with modern radiotherapy equipment and radical surgery, it is difficult to cure. Moreover, the trauma is large and the side effects are severe. It may deprive young patients of their reproductive function and bring physical and mental pain. and the impact on the patient's quality of life are often unacceptable or intolerable to many women
For this reason, scholars have been committed to seeking new minimally invasive, less side effects, and limited effect methods that can cure tumors. With the continuous advent of new chemotherapy drugs and the continuous development of chemotherapy techniques, chemotherapy plays an increasingly important role in the treatment of cervical cancer. Important, but most anti-tumor drugs in modern medicine lack the effect of selectively inhibiting tumors. While killing tumor cells, they are often accompanied by varying degrees of toxic reactions

Method used

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  • Drug composition for treating cervical cancer and preparation method thereof
  • Drug composition for treating cervical cancer and preparation method thereof
  • Drug composition for treating cervical cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0192] Embodiment 1: pharmaceutical composition suppository of the present invention

[0193] Yinhua 3kg Curcuma 6kg Forsythia 3kg Centipede 3kg Comfrey 3kg Phellodendron 3kg;

[0194]Take the raw materials curcuma and forsythia and add 8 times the water by weight, extract for 8 hours to get 25-30 μl of volatile oil and extract a; take the raw materials Yinhua and centipede, add 8 times the water, decoct 2 times, each time 1 hours, to obtain the extraction solution b; take the raw material Phellodendron Phellodendri and Comfrey, add 70% ethanol to extract twice, reclaim the ethanol, and obtain the extraction solution c; combine the above extraction solutions a, b and c, concentrate, dry, and obtain the medicine powder, and extract the powder Rate is 12%; Get semi-synthetic fatty acid ester 40g, get above-mentioned medicated powder 8g, spray into above-mentioned gained volatile oil again, make 3500 suppositories of pharmaceutical composition of the present invention by conventi...

Embodiment 2

[0195] Embodiment 2: pharmaceutical composition suppository of the present invention

[0196] Yinhua 4kg Curcuma 3kg Forsythia 2kg Centipede 4kg Comfrey 4kg Phellodendron 2kg;

[0197] Take raw materials curcuma and forsythia and add 8 weight times of water, extract for 8 hours to get 30-40 μl of volatile oil and extract a; take raw materials silver flower and centipede, add 8 weight times of water, decoct 2 times, each time 1 hours, to obtain the extraction solution b; take the raw material Phellodendron Phellodendri and Comfrey, add 70% ethanol to extract twice, recover the ethanol, and obtain the extraction solution c, combine the above extraction solutions a, b and c, concentrate, dry, and obtain the drug powder. Rate is 12%; Get semi-synthetic fatty acid ester 20g, get above-mentioned medicated powder 8g, spray into above-mentioned gained volatile oil again, make 3500 suppositories of pharmaceutical composition of the present invention by conventional method.

Embodiment 3

[0198] Embodiment 3: pharmaceutical composition suppository of the present invention

[0199] Yinhua 2kg Curcuma 7kg Forsythia 4kg Centipede 2kg Comfrey 2kg Phellodendron 4kg;

[0200] Take raw materials curcuma and forsythia and add 8 weight times of water, extract for 8 hours to get 20-25 μl of volatile oil and extract a; take raw materials silver flower and centipede, add 8 weight times of water, decoct 2 times, each time 1 hours, to obtain the extraction solution b; take the raw material Phellodendron Phellodendri and Comfrey, add 70% ethanol to extract twice, reclaim the ethanol, and obtain the extraction solution c; combine the above extraction solutions a, b and c, concentrate, dry, and obtain the medicine powder, and extract the powder Rate is 12%; Get semi-synthetic fatty acid ester 60g, get above-mentioned medicated powder 8g, spray into above-mentioned gained volatile oil again, make 3500 suppositories of pharmaceutical composition of the present invention by conven...

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Abstract

The invention discloses a drug composition for treating the cervical cancer and a preparation method thereof. The drug composition comprises the following raw drugs: honeysuckle, zedoary, forsythia, chilopod, sinkiang arnebia root and amur corktree bark. The preparation method is characterized by firstly extracting the zedoary and the forsythia to obtain volatile oil, preparing the rest raw drugsinto powder and mixing the powder with the volatile oil to further process clinically acceptable external preparations including but not limited to suppository, effervescing agents, sprays, aerosol or paste. Pharmacodynamic experiments show the drug composition has remarkable anti-inflammatory effect and boosts cell apoptosis by differentiation-transformation, thus having effect on the SiHa cell of human cervical squamous cell carcinoma. The drug composition can directly inhibit growth of the cervical cancer cells, can achieve the aim of inhibiting tumors by regulating the molecular mechanismof P53 gene expression and is a safe, effective and side-effect-free external traditional Chinese drug preparation for preventing cervical lesions.

Description

field of invention [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for preventing and treating cervical cancer and a preparation method thereof. Background technique [0002] Cervical cancer is the second most common cancer in women, and even ranks first in some developing countries; there are about 500,000 new cases of cervical cancer in the world every year, and more than 200,000 people die from cervical cancer, of which 80% of the deaths occur in developing countries. There are 131,500 new cases of cervical cancer in my country every year, accounting for 28.8% of the total number of new cases of cervical cancer in the world. With the development of molecular biology and epidemiology, the research on the relationship between human papillomavirus (human papillomauirus, HPV) infection and lower reproductive tract diseases continues to deepen. It has been confirmed that the relation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P15/00A61P35/00A61K35/64A61K35/648
Inventor 金哲
Owner DONGFANG HOSPITAL BEIJING UNIV OF CHINESE MEDICINE
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