Cefmetazole-containing pharmaceutical composition
A technology of cefmetazole sodium and its composition, which is applied in the field of new pharmaceutical preparation compositions, can solve the problems of unsatisfactory dissolution speed, increase of dissolution speed, and stability problems, and achieve rapid dissolution, ensure stability, and durability  Good effect
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Embodiment 1
[0052] Cefmetazole sodium 500g;
[0053] Mannitol 150g;
[0054] Calcium EDTA 2g;
[0055] Vitamin C 1.5g,
[0056] 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4,
[0057] Add water for injection to 4000ml
[0058]
[0059] 1000 bottles
[0060] Preparation: First mix 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution, then take the above-mentioned amount of cefmetazole sodium, mannitol, calcium EDTA, vitamin C and dissolve in citric acid buffer solution, and then dilute to 4000ml, filtered through a filter membrane with a pore size of 0.22um, after the clarity is qualified, filled, half-tightened, freeze-dried in a box, packaged, and ready to use. Wherein, the preparation method of disodium hydrogen citrate and trisodium citrate buffer solution is as follows: weigh disodium hydrogen citrate 13g,...
Embodiment 2
[0062] Cefmetazole sodium 1000g;
[0063] Mannitol 200g;
[0064] Calcium EDTA 3g;
[0065] Vitamin C 2g,
[0066] Disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4 2000ml
[0067] Add water for injection to 4L
[0068]
[0069] 1000 bottles
[0070]Preparation: First mix 1000ml of disodium hydrogen citrate and trisodium citrate buffer solution, then take the above-mentioned amount of cefmetazole sodium, mannitol, calcium EDTA, vitamin C and dissolve in citric acid buffer solution, and then dilute to 4000ml, filtered through a filter membrane with a pore size of 0.22um, after the clarity is qualified, filled, half-tightened, freeze-dried in a box, packed, and ready to use. Wherein, the preparation method of disodium hydrogen citrate and trisodium citrate buffer solution is as follows: weigh disodium hydrogen citrate 13g, trisodiu...
Embodiment 3
[0072] Cefmetazole sodium 500g;
[0073] Mannitol 100g;
[0074] Calcium EDTA 1g;
[0075] Vitamin C 1g,
[0076] Disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4 2000ml
[0077] Add water for injection to 4L
[0078]
[0079] 1000 bottles
[0080] Preparation: First mix 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution, then take the above-mentioned amount of cefmetazole sodium, mannitol, calcium EDTA, vitamin C and dissolve in citric acid buffer solution, and then dilute to 4000ml, filtered through a filter membrane with a pore size of 0.22um, after the clarity is qualified, filled, half-tightened, freeze-dried in a box, packaged, and ready to use. Wherein, the preparation method of disodium hydrogen citrate and trisodium citrate buffer solution is as follows: weigh disodium h...
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