Ibuprofen nanoparticle with low renal toxicity and preparation method thereof

The invention relates to an ibuprofen nanoparticle with low renal toxicity and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The nanoparticle is prepared by placing ibuprofen, a plant-derived functional natural product auxiliary material, a flow aid and ball-milling beads in a ball-milling tank and carrying out a co-grinding reaction at a certain rotating speed, and the ibuprofen is uniformly entrapped in a carrier under the action of mechanical force, so that an ibuprofen nanoparticle product with low renal toxicity is obtained. According to the ibuprofen nanoparticle and the method, the nanoparticle is prepared through a limited preparation method, the operation is simple, the use of an organic solvent is avoided, the problems about raw material loss, thermal decomposition and the like caused by solvent residues and a solvent thermal removal process are prevented, and the advantages of high preparation efficiency, safe and reliable production, low production cost, less pollution and the like are achieved; and meanwhile, a plant-derived macromolecule is adopted as the carrier, so that the renal toxicity of the ibuprofen is reduced while solubilization and synergism are achieved, and the macromolecule is of great importance to safe medication of a non-steroidal anti-inflammatory drug.