111 results about "Antipyretic" patented technology

Methods and compositions containing bicifadine are provided for the treatment and prevention of hyperthermia in mammalian subjects. The methods and compositions may be used to prevent or treat fever, pyresis, menopausal hot flashes; peri menopausal hot flashes, postmenopausal hot flashes, hot flashes caused by anti-estrogen therapy, hot flashes secondary to surgical removal of estrogen producing tissue, hot flashes caused by radiation therapy, malignant hyperthermia, serotonin syndrome, heat stroke, febrile seizures, and neuroleptic malignant syndrome, among other conditions. Additional compositions and methods are provided employing bicifadine to treat pyresis and simultaneously elicit an analgesic response in mammalian subjects. Yet additional compositions and methods are provided which employ bicifadine in combination with a second antipyretic agent, a second analgesic agent, or a different therapeutic agent to yield more effective antipyretic treatment tools, and / or dual activity therapeutic methods and formulations useful to prevent or reduce hyperthermia and one or more additional symptoms (e.g., pain, or depression) in mammalian subjects.

The invention relates to a beverage, in particular to a Pu'er antipyretic beverage and a preparation method thereof. The preparation method is characterized by taking water extracts of Pu'er ripe tea, grosvener siraitia, mesona blume, liquorice and honeysuckle, aspartame, xylitol and vitamin C as the raw materials, proportioning the raw materials according to certain weight and fine-processing the Pu'er antipyretic beverage through the procedures of washing, soaking, cooking hermetically, concocting, mixing uniformly, five-stage filtrating, sterile filling, sterilizing, etc. The Pu'er antipyretic beverage has the effects of eliminating heat and purging fire, generating body fluid to quench thirst, moistening lungs to remove dry, inducing diuresis and relieving summer heat, lowering cholesterol, lipid and blood pressure, aiding digestion, etc.

The application discloses a Shiniu antipyretic oral liquid which is prepared by processing the following traditional Chinese medicines and water, wherein the traditional Chinese medicines comprise the components by mass percent: 39% of raw gypsum, 6.5% of cornu bubali, 3.25% of radix scutellariae, 3.25% of coptidis rhizome, 6.5% of radix scrophulariae, 6.5% of radix rehmanniae, 1.96% of fructus forsythiae, 1.96% of platycodon grandiflorum, 1.96% of bupleurum, 1.96% of calvatia gigantea, 1.96% of fructus arctii, 1.96% of gardenia jasminoides, 0.67% of stiff silkworm, 0.67% of rhizoma cimicifugae, 1.96% of radix isatidis, 1.3% of tangerine peel, 1.3% of liquorice, 3.25% of rhizoma anemarrhenae, 2.17% of the root bark of the peony tree, 2.17% of red peony root, 6.5% of fresh bamboo leaves, 2.17% of American ginseng and 1.08% of fructus amomi. The Shiniu antipyretic oral liquid has the advantages of good heat clearing effect, low side effect and good patient tolerance.

The invention relates to non-sterides antipyretic-analgesic and anti-inflammatory drug with enteric solubility and the preparation thereof; when the non-sterides antipyretic-analgesic and anti-inflammatory drug is taken orally, the confessed side effects such as nausea, emesis, gastric ulcer, gastric perforation, gastrorrhagia, edema, and the like on the gastrointestinal tract of human body and animals caused by the drug are avoided.

The invention discloses antipyretic gel, which comprises the following raw materials according to the following mixing relationship: 2.9 to 3.1g of carbopol, 180 to 220ml of propylene glycol, 6 to 10ml of ammonia water, 0.3 to 0.5g of ethyl p-hydroxybenzoate, 0.1 to 0.12g of menthol, 0.1 to 0.12g of borneol, 45 to 55ml of ethanol and 1000 to 1400ml of water. The raw materials are stirred and mixed into a gel state. After being adopted, the antipyretic gel has the advantages that the fever (particularly paediatric fever) curative effect is obvious, the use is simple, convenient and fast, and safety, reliability and painlessness are realized.

The invention discloses a N, N'-difluoro-substituted-phenyl derivative of 4-methoxyl-1, 3-phenyldiamide, and relative application, while the compound can restrain platelet aggregation activity, to treat the diseases as cardiac infarction, cerebrovascular disorder, pulmonary embolism and atherosclerosis, with antipyretic, analgesia, and antiphlogistic activities.

The invention belongs to an external thermal therapy bag made of traditional Chinese medicine for external application for treating aches and pains in human necks, shoulders, waists and legs. The conventional treatment includes medication, physical treatment, acupuncture, massage and the like. The treatment with western medicaments is usually implemented by using analgesic antipyretics which can relieve aches and pains temporarily, but are not suitable for long-term treatment. The aim of the invention is to treat aches and pains in necks, shoulders, waists and legs by combining a traditional Chinese medicinal formula and mineral elements. The 14 kinds of raw material medicaments of the external thermal therapy bag include myrrh, szechuan lovage rhizome, pepper, incised notopterygium rhizome, garden balsam stem, unprocessed radix aconite and the like; the raw material medicaments are crushed, screened and uniformly mixed with sodium chloride natural mineral element particles; and the mixed is filled into a cloth bag made of pure cotton, and cloth bag is sealed to be used as external thermal therapy bag for heating. The external thermal therapy bag has the advantages that: the clinic treatment of 208 people with cervical spondylosis show that the rate of effectiveness is 47.60 percent and that the total rate of effectiveness is up to 97.67 percent; and the aches and pains in necks, shoulders, waists and legs, which are caused by cervical spondylosis, scapulohumeral periarthritis, lumbar muscle strain, protrasion of the lumbar intervertebral disci, soft tissue injury and the like can be cured effectively.

A lysine ketoprofen with antipyretic, analgesia and anti-inflammatory functions and its production are disclosed. The process is carried out by proportioning lysine with ketoprofen in 1:1mol to obtain the final product. Its advantages include higher pharmacodynamic strength, better solubility, safety and stability and low side effect.

The invention discloses an eucommia bark and honeysuckle tea and a preparation method thereof. The eucommia bark and honeysuckle tea is prepared from the following raw materials in parts by weight: 200-800 parts of eucommia bark leaf, 30-60 parts of honeysuckle, 3-10 parts of honey, 3-10 parts of liquorice and 5-20 parts of red date. The manufacture method comprises the following steps: killing out the eucommia bark leaf; simmering the honey, the liquorice and the red date with water for 1-3 hours, wherein the ratio of material to water is 1:20; filtering; mixing filtrate with the eucommia bark leaf; placing the mixture at 15-20DEG C for 24 hours; kneading to shape; putting one layer of honeysuckle in a container; laying one layer of gauze; laying one layer of eucommia bark leaf on the gauze, and repeating the operation; and placing at 15-20DEG C in the sealed environment for 24 hours. The eucommia bark and honeysuckle tea has the efficacy on lowering sugar pressure, resisting virus, enhancing an immunologic function, resisting inflammation, relieving inflammation or internal heat, and wetting whistle, antipyretic and the like. Natural taste and pure perfume can be effectively guaranteed with the special preparation method. The eucommia bark honeysuckle tea is good for both children and adults and is convenient to drink.

The invention discloses an ageratum-scutellaria baicalensis antipyretic granule, relates to a pharmaceutical composition, and in particular relates to a pure natural botanical composition. The pure natural botanical composition is prepared from the following raw materials in parts by weight: 5-15g of ageratum, 5-15g of scutellaria, 5-15g of fructus forsythiae, 5-15g of folium isatidis, 10-20g of gypsum, 10-20g of sweet wormwood and 5-15g of radix bupleuri. Aiming at a situation that no Chinese patent medicine for treating summer-heat, dampness, cold and fever exists in the current market, the invention discloses an ageratum-scutellaria decoction for treating summer-heat, dampness, cold and fever according to many-year clinical experience, and adopts a modern pharmaceutical technology for overcoming the defects of the decoction and well achieving curative effect on treating summer-heat, dampness, cold and fever by the original prescription, and the original decoction is changed into the ageratum-scutellaria baicalensis antipyretic granule which has a good curative effect, is convenient to take and carry, has good mouthfeel and is acceptable by children.

The present invention concerns the field of nutritional compositions and concerns a nutritional composition, especially an infant formula containing whey protein / milk protein concentrate solids rich in phospholipids, rich in MFGM for use in the prophylaxis and prevention of infectious morbidity, especially otitis. At the same time the use of antipyretics has diminished.

The invention discloses the application of a 15-methylene replaced andrographolide derivant as shown in general formula 1 in preparing anti-inflammatory, antipyretics and analgetics drugs, pertaining to the pharmaceutical chemistry field. Mice auricular swelling induced by dimethylbenzene, cotton ball granuloma of mice, hyperpyrexia of rats induced by yeast, mouse hot-plate test, writhing test of mice and other models are used for testifying that the 15-methylene replaced andrographolide derivant has anti-inflammatory, antipyretic and analgetic functions. Compared with andrographolide, the 15-methylene replaced andrographolide derivant has better anti-inflammatory, antipyretic and analgetic functions, and the research result of mouse acute toxicity test shows that the toxicity of the 15-methylene replaced andrographolide derivant is very slight. The 15-methylene replaced andrographolide derivant has relatively good application prospect by being applied to the development of anti-inflammatory, antipyretics and analgetics drugs.

The invention provides an antipyretic and analgesic drug. Or a stereoisomer, hydrate, deuterated substance, ester, solvate, crystal form, metabolite, pharmaceutically acceptable salt or prodrug thereof; the structure of the antipyretic and analgesic drug is shown as a formula I. The antipyretic and analgesic drug, or stereoisomers, hydrates, deuterated substances, esters, solvates, crystal forms,metabolites, pharmaceutically acceptable salts or prodrugs thereof, has stronger clinical advantages and smaller toxicity, and is more suitable for antipyretic and analgesic treatment.

The invention discloses an antiviral antipyretic compound Chinese herbal medicine preparation and a preparation method thereof. The antiviral antipyretic compound Chinese herbal medicine preparation is prepared from, by weight, 10-30 parts of folium isatidis, 120-200 parts of radix scutellariae, 120-200 parts of flos lonicerae, 1-1.5 parts of calculus bovis artifactus, 60-120 parts of fructus forsythiae, 20-40 parts of herba lophatheri, 20-40 parts of fructus arctii, 0.2-2 parts of oleum menthae, 2-20 parts of extractum glycyrrhizae and the balance being PH modifier. The weight of the PH modifier needs to meet the requirement of regulating the PH value of the compound Chinese herbal preparation to be 7 to 9. By optimization of the radix scutellariae extraction process and use of the PH modifier, the absorption characteristic of radix scutellariae extract is improved, bioavailability of the radix scutellariae extract is increased, and thus, antiviral pharmacodynamics activity of the compound Chinese herbal medicine preparation is improved.

The invention relates to a hard capsule which contains etodolac, the substance in the capsule contains glutin as anti-crosslinking agent; the hard capsule which contains etodolac has the advantages of good stability, avoiding the crosslinking reaction on the capsule shell, being applicable to analgesia, diminishing inflammation and antipyretic.

An antipyretic comprises radix bupleuri, cassia twig, sweet wormwood, mint, and liquorice. The antipyretic provided by the invention is prepared from traditional Chinese medicine components, and liquorice is used for enhancing detoxification function of liver, thereby the antipyretic has no side effects, cannot cause harm to liver, can kill virus basically, and has no recurrence.

A method is provided for treatment of an infective condition in a fluid-containing organ having a natural exterior orifice, such as the udder of a milk producing animal or an ear. The method comprises administering an antibacterial agent to the organ via the exterior orifice and administering in combination therapy with the antibacterial agent a second agent that is an anti-inflammatory agent, an analgesic and / or an antipyretic. The antibacterial agent and, optionally, the second agent, are administered as a pharmaceutical composition further comprising a vehicle that comprises an amphipathic oil that is water dispersible and ethanol insoluble, microcrystalline wax and a pharmaceutically acceptable non-aqueous carrier. Also provided is such a composition comprising the antibacterial agent and the second agent. The composition is readily dispersible in the fluid of the fluid-containing organ.

The invention discloses antipyretic health-care vermicelli, which is prepared by mixing one or more of mung bean, pea, broad bean and cassava powder, water chestnut powder and mashed spinach, adding a proper amount of water for blending to form starch paste, processing the starch paste into vermicelli and airing or drying, wherein the mixing ratio of the bean powder to the cassava powder to the mashed spinach is 35-60: 20-60: 5-10. The mashed spinach is prepared by the following method of: cleaning spinach, putting the spinach into the water of 90 to 100 DEG C, soaking the spinach for 1 to 3 minutes at the temperature, fishing out the spinach, draining the moisture, and mashing the spinach into mud shape. Because the spinach and the water chestnut with rich nutrition are added into the bean powder and the cassava powder, not only the appearance (the appearance is light green) of the vermicelli is changed, but also the nutrition and health-care values of the vermicelli are higher. Meanwhile, because the spinach and the water chestnut belong to cool vegetables, the spinach and the water chestnut are particularly suitable for hotpots, and have the effects of assisting digestion, moistening dryness and bowels, helping producing saliva and slaking thirst, clearing heat and relieving fidgetiness.

The invention relates to an application of a flurbiprofen axetil pharmaceutical composition in preparing antipyretics. The flurbiprofen axetil pharmaceutical composition consists of flurbiprofen axetil, oil, egg yolk lecithin, glycerol, disodium hydrogen phosphate, citric acid and injection water, wherein the concentration of the flurbiprofen axetil is 0.1-10mg / ml, the concentration of the oil is 100mg / ml and the concentration of the egg yolk lecithin is 12mg / ml. The flurbiprofen axetil pharmaceutical composition disclosed by the invention can be used for relieving fever of a rat caused by dried yeast.

The invention provides a formula of antifebrile gel roll-on bead and a preparation method. According to the invention, the problem that traditional physical methods such as cold compress, warm water rubdown, gel paste, etc. have slow antifebrile effect is overcome, and ethanol is not used so as to avoid ethanol absorption and anaphylactic reaction of human body. More importantly, volatile components in natural Chinese herbal medicines are used as a main antipyretic, which belongs to a physical cooling process and avoids side-effect caused by drug use for defervesce. In addition, mint and lavender essential oil can have effects of raising spirit and restoring consciousness and soothing emotions. The product is safe and nontoxic, has definite therapeutic effect, is convenient to use and carry and is suitable for defervesce processing for people of all ages.

The invention relates to an antipyretic medicine which comprises the following raw materials by weight: 30g plaster stone, 10g cortex lycii radicis, 3g indico naturalis, 15g lonicera japonica, 10g weeping forsythia, 10g radix rehmanniae, 10g chrysanthemum, 10g radix ophiopogonis, 6g radix scrophulariae and 5g mint (taking at night). A taking method of the medicine comprises the steps that the plaster stone, the cortex lycii radicis, the indico naturalis, the lonicera japonica, the weeping forsythia, the radix rehmanniae, the chrysanthemum, the radix ophiopogonis and the radix scrophulariae are mixed and put into a medicine pan; 1000g clear water is added for soaking for 30min; boiling is performed by a big fire; slow decoction is performed by a slow fire until 450g water is remained; 5g mint is added and decocted for 2min; dregs are removed; a filtrate is obtained; and a dose is taken every day after the filtrate is at a room temperature. The medicine is taken 1h after a dinner every day, and a patient can be cured after taking 2-4 doses. By clinical use demonstration, the medicine has a good effect on treating a fever and unknown heat energy; the medicine has the advantages that the medicine is high in effectiveness and low in cost, and the raw materials are easy to obtain and easy to prepare; the medicine has no toxic or side effects; and the safety of medicine use of the patient is ensured.

The invention relates to synthesis and application of a medicament ibuprofen lysine. currently, the medicinal popularity of the ibuprofen lysine reaches above 95% in large cities, however, the water solubility of the ibuprofen lysine is poor, so that the preparation types and clinic application of the ibuprofen lysine are limited. The invention aims at the synthesis and application of the ibuprofen lysine, namely, preparation of high-purity compound solid bulk pharmaceutical chemical and applications of the pharmaceutical chemical as water-soluble non-steride antipyretic, analgesia and anti-inflammatory agent formulations. The synthesis method comprises the following steps: dissolving lysine in purified water so as to obtain a solution A; dissolving ibuprofen in ethanol so as to obtain a solution B; respectively adding activated carbon for decoloration and filtration, mixing, and putting the mixture in a kettle to react for 0.1-12 hours at the temperature of 0-80 DEG C; then cooling to room temperature, replenishing the ethanol, freezing and crystallizing at the temperature of minus 30 DEG C-0 DEG C; and centrifuging, washing with the ethanol, centrifugally drying, and baking, so as to obtain the white or white-like crystal ibuprofen lysine. The ibuprofen lysine has the effects that antipyretic and analgesia speed is faster than that of the ibuprofen, biological utilization degree is higher than that of the ibuprofen, toxic effect is low, and stability is good.

The invention provides a veterinary antipyretic and antiviral medicine composite. The medicine composite is prepared from the following raw material medicines in a defined ratio: bupleurum, isatis root, fineleaf schizonepeta herb, wild ginger, reclaimed gypsum and cornu bubali. The medicine composite of the invention has unique formula and has the functions of dispelling the evil in the superficies with drugs of pungent, strengthening body resistance and eliminating evil, and clearing heat and detoxication; the composite has strong pathogenic microorganism resistance function, has antipyretic, antiviral, antibacterial and antiphlogistic effects, increases the immunity of the organism; and the root cause and symptoms of the livestock and poultry hyperthermia caused by the viral infection can be both eliminated, the curative effect is outstanding, the effective rate is over 90% and the medicine composite has no obvious toxic or side effect.

A burn and scald wound treatment spray, its raw materials and weight components are: 120-260 parts of earthworms (fresh), 5-15 parts of borneol, 300-550 parts of white sugar, 20-40 parts of Coptis chinensis, and 20-40 parts of Cortex Phellodendri 20-40 copies of Sichuan Army. Preparation method: step 1, wash and chop the earthworms (fresh) in the said weight portion, add white sugar, seal them into a slurry, filter and remove the slag; step 2, decoct Coptis chinensis, Cortex Phellodendri, and Chuanjun in water, and take 80-120 wt. Part, add borneol and filter; step 3, make the mixed solution obtained in steps 1 and 2 into an atomizer for use. It has the functions of antipyretic and pain relief, antibacterial and anti-inflammation, detumescence and astringent muscles, dissolving thrombus, and prolonging coagulation time. It is used for emergency treatment of burns and scald wounds, relieves pain immediately, and prevents wounds from worsening infection. Has a rapid healing effect.

The heat removing and cough relieving medicine is one kind of Chinese medicine prepared with sessile stemona root, phellodendron bark, flavescent sophora root, polygala root, cnidium fruit and skullcap root.

The invention relates to the field of traditional Chinese medicine preparations, in particular to gel paste for the gynecology department and a preparation method of the gel paste. The gel paste is prepared from the following raw materials: flos carthami, galla chinensis, cortex phellodendri, flos lonicerae and fructus cnidii. The flos carthami has anti-inflammatory and disinfecting effects; the galla chinensis has astringent and antimicrobial effects; the cortex phellodendri has the effects of clearing heat and removing toxicity, and discharging fire and eliminating dampness; the fructus cnidii has the effects of dispersing cold and removing dampness, expelling wind and killing insects, and is used for relieving gynecologic inflammation; and the flos lonicerae is antibacterial, antiviraland antipyretic; and the gel paste is prepared from pure traditional Cchinese medicinal materials, is free of toxic and side effects, clean and fragrant, has the advantages of being convenient to use,good in curative effect, remarkable in effect, safe in using and free of the toxic and side effects, and can be used for treating and preventing of gynecological diseases, vagina contracting and ovary maintaining.

The invention relates to the field of Chinese medicinal preparation, and particularly discloses a bupleurum antipyretic and analgesic preparation and a technology for preparing the same. The bupleurum antipyretic and analgesic preparation contains bupleurum essential oil, saikoside and pharmaceutical adjuvant, wherein the volume to weight ratio of the bupleurum essential oil and the saikoside is 1 / 0.5-10(ml / g). Preferably, the volume to weight ratio of the bupleurum essential oil and the saikoside is 1 / 1-6(ml / g). Meanwhile, the invention discloses a technology for preparing the bupleurum antipyretic and analgesic preparation. The bupleurum antipyretic and analgesic preparation provided in the invention has obvious antipyretic and analgesic effects, and has wide administration routes.

The invention discloses a preserved egg antipyretic intestine-heat reducing red date fruitcake characterized by comprising the following raw materials by weight parts: glutinous rice 500-550, red date 300-350, egg white 200-240, pectase 1-2, milk 400-450, lactic acid bacteria 0.5-1, citric acid 0.8-0.9, malic acid 0.5-0.6, cane sugar 20-24, mint juice 9-10, and wine 250-260. The preserved egg antipyretic intestine-heat reducing red date fruitcake is smooth in taste, and red date nutrition can be fully dissolved; the glutinous rice has tea fragrance; the fruitcake is sour-sweet moderate, and has aromatic flavor.

The invention discloses a compound antipyretic-analgesic and anti-inflammatory drug composition preparation for livestock and application thereof, belongs to the field of drugs for livestock, and specifically relates to a medicinal composition containing non-steroidal anti-inflammatory drugs and honeysuckle and scutellaria baicalensis extracts (honeysuckle extract chlorogenic acid and scutellariabaicalensis extract baicalin). The medicinal composition comprises the following active components in parts by mass: 1-1,000 parts of non-steroidal anti-inflammatory drugs, and 1-100 parts of honeysuckle and scutellaria baicalensis extracts. The medicinal preparation can be one or combination of injection, syrup, oral solution and other liquid preparations, common tablets, dispersible tablets, sustained release tablets, capsules, granules, powder and other solid preparations, ointments, paste, gel and other semi-solid preparations. The compound antipyretic-analgesic and anti-inflammatory drugcomposition preparation is obvious in coordination effect in animal antipyretic-analgesic and anti-inflammatory sides and can effectively reduce adverse effect of the medicine; the compound antipyretic-analgesic and anti-inflammatory drug composition preparation is obvious in treatment effect, stable in quality, high in safety, simple in preparation method, and suitable for industrial production.

The invention discloses an antipyretic and antidotal oral preparation and a preparation method thereof. The antipyretic and antidotal oral preparation is prepared from, by weight, 2000-3000 parts of flos lonicerae, 2000-3000 parts of fructus forsythiae, 2000-3000 parts of spica prunellae, 1000-1500 parts of cortex moutan, 2000-3000 parts of herba taraxaci, 2000-3000 parts of gypsum, 2000-3000 parts of christina loosestrife herb and 1000-1500 parts of radix bupleuri. By using the method that distillation extraction is combined with decoction extraction, the main medicinal compositions of the medicine materials are extracted, and the corresponding oral preparation is prepared by adding corresponding ingredients according to a known oral preparation method. The defects that parenteral administration causes many adverse reactions, such as the first pass effect and pain of a patient are avoided, the oral preparation is convenient to take, no pain is caused, and the oral preparation is particularly suitable for child patients to accept. Through pharmacodynamic experiments, it is proved that the oral preparation is mainly used for viral infection, an agnogenic high fever and acute and chronic inflammation, and the oral preparation is particularly suitable for patients who are resistant or allergic to antibiotics.