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Application of bladder cancer prognosis lifetime marker, evaluation device and computer readable medium

A marker, bladder cancer technology, applied in the field of oncology, can solve problems such as difficult to predict disease progression and poor overall survival

Active Publication Date: 2022-07-29
GENESEEQ TECH INC +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Previous studies reported that patients with high stage or positive lymph nodes had poorer overall survival (OS)
However, due to the biological heterogeneity of bladder cancer, it is difficult to predict disease progression if the prognosis is only assessed based on clinical features such as TNM stage and lymph node status

Method used

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  • Application of bladder cancer prognosis lifetime marker, evaluation device and computer readable medium
  • Application of bladder cancer prognosis lifetime marker, evaluation device and computer readable medium
  • Application of bladder cancer prognosis lifetime marker, evaluation device and computer readable medium

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Embodiment Construction

[0047] In the present invention, the training set is from 185 bladder cancer patients screened from MSK-IMPACT targeted sequencing data (PMID: 25092538 and MSK, 2020), and the validation set is from 265 selected from TCGA WES sequencing data (PMID: 28988769) patients with bladder cancer. Through univariate Log-rank analysis and multivariate Cox regression analysis on the clinical characteristics (age, gender, lymph node status) and genomic characteristics (gene variants with a frequency greater than 5%) of the patients in the training set, 5 characteristics were confirmed to be bladder An independent predictive marker for overall survival of cancer patients was constructed, and a joint discriminant model with high classification accuracy was constructed, and the predictive ability of the model was further verified using the validation set.

[0048] The definition of "gene mutation" in the present invention includes single nucleotide mutation, indel mutation, missense mutation,...

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Abstract

The invention relates to application of a bladder cancer prognosis lifetime marker, an evaluation device and a computer readable medium, and belongs to the technical field of tumor medicine. Single-factor and multi-factor analysis is carried out on genome sequencing data of tumor samples of a large number of bladder cancer patients, the correlation between each factor and the total lifetime is evaluated, a five-feature prognosis model including a lymph node state, TOP1 amplification, MYC amplification, CREBBP mutation and a CDKN2A deletion state is established, the model can effectively carry out prognosis stratification of the bladder cancer patients, and the prognosis stratification of the bladder cancer patients is realized. A reference basis is provided for clinical diagnosis and treatment.

Description

technical field [0001] The invention relates to an application, an evaluation device and a computer-readable medium of a bladder cancer prognosis and survival marker, and belongs to the technical field of tumor medicine. Background technique [0002] Bladder cancer is the most common urinary tract malignancy worldwide, with approximately 430,000 new cases and 165,000 deaths annually. Bladder cancer (BLCA) is a highly common cancer caused by the urothelium, and 95% of bladder cancers are urothelial cancers, also known as transitional cell carcinomas. Currently, bladder cancer can be divided into two major categories based on tumor stage: non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). Features of NMIBC include coactivation of FGFR3 mutations, a higher recurrence rate (50-70%), and a higher 5-year survival rate (>90%). However, MIBC is characterized by frequent TP53 mutations, a high rate of metastasis, and a 5-year survival rate of l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G16B20/50G16B30/00
CPCC12Q1/6886G16B30/00G16B20/50C12Q2600/118C12Q2600/158
Inventor 郑丽娟邵阳许斌张雅儒汪笑男吴雪包华
Owner GENESEEQ TECH INC
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