48 results about "Arteriole" patented technology

A method and system for determination and mapping the quantity of chromophores having a distinct spectrum attached to moving objects in an spectrally rich environment that may include multiple chromophores attached to stationary objects. An area of inters is imaged at different times and different wavelengths, and the spectral properties of the or more chromophores attached to the moving objects are separated from the stationary spectral properties of the background, followed by spectral analysis of the moving objects to determine their quantity. Application to the retinal vasculature is illustrated, showing the imaging, analyzing and quantifying of the oxygen saturation of retinal blood, resolved for the different vascular compartments—capillaries, arterioles, venules, arteries, and veins. Changes in the structure of the vascular environment are also determined, whether growth of new vessels or the elimination of existing ones, by the generation of path maps based on analysis of differential images taken at a single wavelength of the moving components in the blood flow.

A method and system for determination and mapping the quantity of chromophores having a distinct spectrum attached to moving objects in an spectrally rich environment that may include multiple chromophores attached to stationary objects. Au area of interest is imaged at different times and different wavelengths, and the spectral properties of the chromophores attached to the moving objects are separated from the stationary spectral properties of the background, followed by spectral analysis of the moving objects to determine their quantity. Application to the retinal vasculature is illustrated, showing the imaging, analyzing and quantifying of the oxygen saturation of retinal blood, resolved for the different vascular compartments, including capillaries, arterioles, venules, arteries, and veins.

The invention discloses an endogenous optical imaging method for automatically separating arteries and veins and aims at providing an effective endogenous optical imaging method for effectively and automatically separating arteries and veins of organisms. In the technical scheme, the endogenous optical imaging method comprises the following steps of: carrying out spectrum analysis to a collected image sequence by adopting narrow-band quasi monochromatic light for illumination, and then realizing the identification and automatic separation of the arteries and veins by utilizing the amplitude distribution features of low-frequency oscillating signals of the image sequence through the operations of frequency spectrum transformation, enhancement of a local self-adaption contrast, automatic threshold segmentation and the like. The endogenous optical imaging method can be used for automatically separating the arteries and the veins and highlighting and separating the vessel structures of many arterioles and veinlets, thereby avoiding the design complexity of the imaging device using light with various central wavelengths for illumination.

The invention relates to a demonstration model for simulating the pathological change of acute glomerulonephritis. The invention belongs to a medical teaching device, and particularly relates to a teaching aid for demonstrating the pathological change of acute glomerulonephritis. The teaching aid mainly comprises a heart model, an afferent glomerular arteriole model, a glomerular capillary u-shaped loop model, a mesangial region saccus model, an efferent glomerular arteriole model, a renal capsule model, a renal tubule model, a urine pool and a blood pool, thereby forming a model system for demonstrating the pathological clinical correlation of acute glomerulonephritis. The device is simple in structure and convenient to operate, and has high visuality and understandability in the teaching process. Besides, the device facilitates students to foster the observation and problem analysis capabilities.

Disclosed are A3 adenosine receptor antagonists and / or partial agonists of formula (I): wherein R1 to R5 are as described herein, as well as pharmaceutical compositions thereof and methods of use thereof. The antagonists or partial agonists find use in treating a number of diseases including cancer, glaucoma, inflammatory diseases, asthma, stroke, myocardial infarction, allergic reactions, rhinitis, poison ivy induced responses, urticaria, scleroderma, arthritis, brain arteriole diameter constriction, bronchoconstriction, and myocardial ischemia, as well as in preventing cardiac ischemia. Also disclosed are radiolabeled compounds of formula (I) and the use thereof in diagnostic imaging of tissues and organs.

The present invention relates to a therapy system for the treatment of the skin and subdermis with light. The system comprises a NIR light source which produces light with a wavelength adapted to an absorption maximum for exciting molecular oxygen in aqueous solution; an image recognition unit for detecting papillary end arterioles and their x-y-z coordinates, wherein a respective depth underneath the skin surface is determined as the z-coordinate by an autofocus function; an optical system for the optical coupling of the light of the NIR light source and the pattern recognition unit to the skin, with a focussing unit to controllably position the light with at least one focus point in the skin; and a control unit to control the NIR light source, the image recognition unit, and the optical system.

The invention relates to a medicine for in vitro hemostasis and a preparation method of the medicine. The in vitro injury bleeding conditions frequently occur in life; some in vitro injury bleeding conditions are caused by chance; some in vitro injury bleeding conditions are generated by combination with internal causes of the organism; the bleeding is caused by vascular permeability increase of postcapillary venule, capillary vessels and precapillary arteriole; blood leaks out of a lumen through an expanded endothelial cell clearance and a damaged vascular basement membrane, for example, finger injury bleeding, toe injury bleeding, skin scratch bleeding and the like. The medicine is prepared by combining the following raw materials: cirsium japonicum, cuttle bone, herba cirsii, cutch, sanguisorba officinalis, dragon blood, ramie root, loofah sponge, sophora japonica, rheum officinale, puffball, hairyvein agrimony, shrubalthea bark, rhizoma bletillae, alumen, crinis trachycarpi, coptis chinensis, folium artemisiae argyi, indigo naturalis, panax notoginseng, carbonized hair, pericarpium granati, cattail pollen, dark plum, ophicalcite, mongolian snake gourd roots, selaginella tamariscina, halloysitum rubrum, schizonepeta and cacumen biotae. The raw materials are combined to generate the synergistic effect in efficacy, so that in vitro injury bleeding can be effectively treated.

The invention discloses an application of 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside in the preparation of microcirculatory disturbance improvement medicines. The microcirculatory disturbance improvement medicines comprise 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside as an effective active component, and one or more pharmaceutically acceptable auxiliary agents, especially gastrodin and / or water-soluble cyclodextrin derivatives and PEG400 and mannitol, wherein the structural formula of 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside is shown in the specification. The microcirculatory disturbance improvement medicines treat 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside as the effective active component, and are used for improving disturbances caused by cerebral microvascular damages and / or disturbances caused by ischemia reperfusion damages and / or disturbances caused by leukocyte adhesion damages, and / or disturbances caused by peroxides. Normal mice of Kunming species and artificially induced microcirculatory disturbance model mice undergo tail vein injection treatment, and results of the observation of arteriole and venule systole and capillary network under a microcirculatory microscope show that 3,5,4'-trihydroxy-stilbyl-3'-O-glucoside has an obvious expansion effect on the blood vessels of the normal mice, can obviously resist the reduction of the arteriole and venule systole and capillary network opening number of the microcirculatory disturbance model mice and can obviously resist the reduction of the blood flow speed.

The invention discloses a method for measuring lesion characteristics of hypertensive retinopathy. The method comprises the following steps: acquiring a fundus image; recognizing an optic disc region of the fundus image and dividing the fundus image into at least three regions including a first region, a second region and a third region based on the optic disc region; performing artery and vein segmentation on the fundus image by using an arteriovenous segmentation model based on deep learning to obtain arteriovenous segmentation results, wherein the arteriovenous blood vessel marking results include an artery marking result, a vein marking result and a small blood vessel marking result; and based on the three regions and the arteriovenous segmentation result, measuring lesion characteristics in the fundus image, wherein the lesion characteristics comprise at least one of arteriovenous cross-indentation characteristics, arteriovenous local stenosis characteristics and arteriovenous general stenosis characteristics. According to the present disclosure, it is possible to provide a measurement method and a measurement system for efficiently and objectively measuring lesion characteristics of hypertensive retinopathy.

A blood pressure status measuring apparatus includes a first photoplethysmographic sensor that includes a light emitting element) outputting near-infrared light and acquires a photoplethysmographic signal of a carotid artery, a second photoplethysmographic sensor that includes a light emitting element outputting blue to yellow-green light and acquires a photoplethysmographic signal of an arteriole or a capillary near the carotid artery, a pulse wave propagation time measuring unit that acquires a pulse wave propagation time on the basis of the photoplethysmographic signal of the carotid artery and the photoplethysmographic signal of the arteriole or the capillary near the carotid artery, a pulse wave propagation time change acquisition unit that acquires a temporal change of the pulse wave propagation time after measurement is started, and a blood pressure status measuring unit that measures circulatory dynamics including a blood pressure status on the basis of the temporal change of the pulse wave propagation time after measurement is started.

The present invention relates to a cosmetic of ginseng saponin bath lotion, the main effective components of which are ginseng saponin, aloe juice and hyaluronic acid. In the main components of the present invention, the ginseng saponin and the aloe juice are raw materials, wherein, the raw material of aloe contains various natural nutrient components, wherein, the natural moistening factor which consists of amino acid and amylase substance can reduce the moisture loss of skin, restore the function of collagen protein and resist forming facial wrinkle; the ginseng saponin is applied to the bath lotion, which can promote the blood circulation and ensure capillary vessels and arterioles produce the expansion action and accordingly reinforces the supply of dermal nutrition; the hyaluronic acid is acidic mucopolysaccharide and has special moisture maintaining effect, which is a best moistening substance in the nature at present, and 2 percent of pure hyaluronic acid aqueous solution which is known as ideal natural moistening factor can maintain 98 percent of the moisture firm. The present invention is matched with other nutrient components to use, which can achieve the more ideal effect of promoting the alimentation.

A percutaneous picking of liquestrazine free alkali for preventing thrombocyte coagulation, expanding arteriole and improving microcirculation is composed of storage layer, adhesive layer, release controlling film, substrate and protecting layer. Its advantages are stable concentration of medicine in blood, sure curative effect and low by-effect.

The invention relates to a Chinese herba preparation for treating radiation pneumonitis. The Chinese herba preparation comprises oldenlandia diffusa, giant knotweed rhizome, mother chrysanthemum, honeysuckle, platycodon grandiflorum, pepperweed seed, dandelion, radix scrophulariae, forsythia, reed rhizome, herba lysimachiae, folium Isatidis, fructus gardeniae, dendrobium, radix curcumae, salix leaf, and musk. The Chinese herba preparation has the effects of clearing away heat and toxic materials, dispersing blood stasis and freeing lung, eliminating carbuncle and eliminating stagnation, and regulating vital energy and relieving cough. After taking, the drug is directly acted on the respiratory system, so as to improve meionectic blood, control infection, prevent lung blood capillary and arteriole from hyperaemia, expansion and embolism, and inhibit the reduction of the gas exchange function and the increase of the pulmonary artery pressure caused by the lung inside fibrosis, alveolar septum thickening, pulmonary alveoli atrophy or blood vessel wall thickening, glassy degeneration and hardening, lumen narrowing or blockage. The Chinese herba preparation reduces the blood vessel permeability, promote the respiratory system and the blood system to recovery the self-regulation function, and finally reach the purpose of healing the radiation pneumonitis.

The invention relates to a new function of amarogentin for preventing or treating pulmonary arterial hypertension, and belongs to the technical field of pharmacological action of a component. It is discovered that the amarogentin has an effect of obviously relieving myocardial hypertrophy, myocardial edema, pulmonary arteriolar wall thickening and stenosis caused by hypoxic pulmonary hypertension. Therefore, the amarogentin can be used for preparing a medicine for preventing and treating related cardiovascular diseases caused by the pulmonary arterial hypertension. The medicine can be prepared into tablet, capsule, granule, pill, powder, injection, emulsion or other pharmaceutically acceptable dosage forms.

The present invention relates to a therapy system for the treatment of the skin and subdermis with light. The system comprises a NIR light source which produces light with a wavelength adapted to an absorption maximum for exciting molecular oxygen in aqueous solution; an image recognition unit for detecting papillary end arterioles and their x-y-z coordinates, wherein a respective depth underneath the skin surface is determined as the z-coordinate by an autofocus function; an optical system for the optical coupling of the light of the NIR light source and the pattern recognition unit to the skin, with a focussing unit to controllably position the light with at least one focus point in the skin; and a control unit to control the NIR light source, the image recognition unit, and the optical system.

The invention discloses an auxiliary therapeutic instrument for rehabilitation of a diabetic foot disease patient. The instrument comprises a bed body, an end of the bed body is slidingly provided with a sliding plate through a supporting sliding rail, an air bag is disposed in an air bag placement box, the upper part of the bed body is fixedly connected with a rubber massage strip, and the surface of the bed body is provided with an infrared radiation treatment lamp; two sets of pin openings are formed in the side wall of one side of a treatment box, a clear water box is installed in the treatment box, the lower portion of a pressurizing pipe communicates with three sets of elastic water bags, and an ultrasonic generator is further installed in the treatment box; a spray header is mountedat the lower part of a cleaning pipe; and the lower part of a pesticide spraying pipe communicates with an atomizing nozzle. Vein vessels and arteriole vessels of feet are dredged in an ultrasonic ablation mode; blood circulation of the feet is promoted, and the situation that the feet are necrotic due to ischemia is reduced; water pressure is combined for massaging feet; meanwhile, atomized treatment liquid medicine is sprayed to the feet through the atomization nozzle, multiple auxiliary treatment is achieved, and the treatment effect is improved.

The invention belongs to the field of medicine, and particularly relates to an application of emulsified perfluorocarbon liquid in preparation of a lung preserving fluid. The emulsified perfluorocarbon liquid has the characteristics of high oxygen carrying capability and high oxygen releasing speed; blood visible components are not contained, so that cytotoxicity and generation of oxygen free radicals are reduced; a pH value is between 7.4 and 7.6, so that cellular acidification can be prevented, and cellular damages caused by activation of protease and phosphatase in cold preservation are inhibited; the colloid osmotic pressure is 390 mmH2O, so that cellular edema can be prevented; particles are small, the oxygen carrying capability is high, the gas exchange speed is fast, the emulsified perfluorocarbon liquid can easily pass through tiny capillaries and partially blocked pulmonary arterioles, the establishment of collateral circulation is promoted, the filling and oxygen supply effects are achieved, and oxidative damages are reduced; the emulsified perfluorocarbon liquid is an inert compound and can form dense and diffused physical barriers on the surfaces of cell membranes, so that the contact of inflammatory factors with target cells is prevented. The emulsified perfluorocarbon liquid is suitable for filling and preserving important transplanting organs such as lungs and the like.

The invention discloses a compound lidocaine aerosol and a preparation method thereof. The compound lidocaine aerosol comprises the following components in parts by weight: 0.2-3.5 parts of lidocaine,0.2-3.5 parts of propylamine caine, 1-3.5 parts of 0.1 M sodium hydroxide, 2-35 parts of propellant, 1-17.6 parts of polyvinyl alcohol and 0.1-1.75 parts of rutin derivative. Under the condition of not containing penetrant and surfactant components, lidocaine and propylamine caine in a basic group form are released to the subcutaneous layer, and polyvinyl alcohol is used for forming a film on thesurface of the skin, so that the dosage of lidocaine and propylamine caine is reduced, and the safety of clinical use is enhanced; the treatment of male premature ejaculation is mainly used for inhibiting the expansion of the minor artery and capillary anterior sphincter of the cavernous body of the penis, so that the smooth muscle is relaxed, and the blood flow volume is increased; the rutin derivative is added, the elasticity and permeability of the drug are improved by improving the capillary function, and adverse reactions such as vascular bleeding caused by long-term use of traditional lidocaine drugs are avoided.

The invention provides a peripheral vascular resistance change tracking method and system, a terminal and a storage medium, which can be integrated into wearable equipment, the change of peripheral vascular resistance is tracked by accurately acquiring arteriole pulse wave transmission time, and the change of peripheral vascular resistance can be continuously tracked on the body surface in real time.

The invention discloses a series of 3-(1H-indazole)-tetrahydropyrimidine-2-one compounds (represented as the general formula I), a preparation method, and a medicinal application thereof. The novel 3-(1H-indazole)-tetrahydropyrimidine-2-one compounds have effects of inhibiting activity of Rho kinase, have the functions of relaxing aorta vessels, brain base arteriole and mesenteric vessels and protecting vascular function and pharmacological effects of promoting consumption of glucose in cells. These novel compounds have important applications in the field of preparing medicines used for preventing and / or treating cardia-cerebrovascular diseases such as hypertension, atherosclerosis, cerebral angiospasm, coronarospasm, myocardial infarction, cardiac failure, diabetes and the like, and diabetes as well as complications thereof, such as diabetic cardiovascular complication, diabetic cerebro-vascular complication and the like.

The invention discloses application of aloperine (ALO) to preparation of a medicine for preventing and curing pulmonary arterial hypertension. A rat pulmonary hypertension model is established to explore the protection effect and mechanism of aloperine on rat pulmonary hypertension. The experiment shows that after the pulmonary hypertension model is established, the aloperine can remarkably improve the hemodynamic parameter, the right ventricular hypertrophy index, the lung index, and the echocardiographic parameter, the pathological injury of pulmonary arterioles is improved, the antioxidant ability of a lung tissue is improved, and the malondialdehyde content and the level of nicotinamide adenine dinucleotide phosphate oxidase (NOX)-2 and NOX-4 in the lung tissue are reduced. The aloperine has the effects of inhibiting the development of pulmonary arterial hypertension, oxidative stress and overexpression of NOX-2 and NOX-4.

The invention discloses an endometrial stem cell preparation for treating erectile disorder and a preparation method thereof. Stem cells are pluripotent cells with self-replication capacity, and the stem cells can be differentiated into multiple functional cells under certain conditions. Through stem cell transplantation, damaged cells are replaced by direct differentiation or a large number of cell factors are secreted in a paracrine mode, so that the treatment process is simplified, which is different from the mode that a medicine only aims at specific molecules or signal channels, and therefore, endometrial stem cells which are tissue repair cells with vascular regeneration and repair activity are cultured in vitro. By adopting a micro-injection planting technology, active cells are planted in a male cavernous body in a targeted manner, so that on one hand, the generation of new small vessels can be promoted, and on the other hand, damaged and blocked arterioles can be repaired, themicrocirculation of blood vessels is improved, and the blood supply speed and blood supply quantity of dorsal arteries to the cavernous body are increased; and a safe and effective treatment means isprovided for treating erectile disorder.

The invention relates to the field of medical monitoring equipment, in particular to a percutaneous newborn target organ blood drug concentration monitoring device. The device comprises a central processor and a vascular induction probe, a target organ induction probe, a monitor and an input device, the vascular induction probe is used for percutaneous monitoring the blood drug concentrations of arterioles and venules, the target organ induction probe is used for monitoring of different target organs, the central processor comprises a drug data storage module, a monitoring data storage module, a monitoring curve generating module, and a comparison alarm module, and the monitoring curve generating module can draw curves according to detected concentration of certain parts in a period of time; the comparison alarm module is used for comparing the monitored concentration value with the maximum effective concentration, and sending out an alarm prompt when the concentration value exceeds the maximum effective concentration. The device can achieve non-invasive measurement of the drug concentration in the newborn body, avoid iatrogenic blood loss and damage to the skin of the newborn, thereby protecting the delicate organ function of the special group.

The invention relates to a traditional Chinese medicine preparation for treating lobar pneumonia. The traditional Chinese medicine preparation contains radix isatidis, herba houttuyniae, polygonum cuspidatum, radix angelicae sinensis, radix ilics pubescentis, wax gourd kernel, pollen, dendrobe, rhizoma belamcandae, ephedra, salix leaf, fel ursi, wild chrysanthemum flower, dandelion, folium isatidis, jasmine and viola. The traditional Chinese medicine preparation has the effects of clearing heat, removing toxic materials, dispersing blood stasis, ventilating the lung, regulating vital energy, invigorating the circulation of blood, dissipating carbuncle, eliminating stagnation and the like; after being taken, the traditional Chinese medicine preparation has double regulation effects of anti-inflammation and body immunity enhancement; the medicine is capable of directly acting on blood vessels and viscera, and thus capable of opening more blood capillaries, expanding arterioles, increasing the blood flow volume in microcirculation, increasing the blood flow velocity, eliminating blood stasis during microcirculatory disturbance and obviously improving the microcirculatory disturbance; the traditional Chinese medicine preparation is further capable of activating the secretion of mononuclear phagocytes, remarkably inhibiting large secretion of the endotoxin factor, thoroughly eliminating symptoms such as high fever, cough, expectoration, chest distress and palpitation, and finally realizing thorough cure of the lobar pneumonia.

The invention discloses a traditional Chinese medicine composition for promoting construction of coronary collateral circulation.The traditional Chinese medicine composition is prepared from ginseng, radix astragali, radix polygoni multiflori, fructus corni, squama manis, hirudo, cortex moutan, radix paeoniae rubra, rhizoma curcumae, herba gynostemmatis pentaphylli, radix ophiopogonis, fructus schisandrae chinensis, semen cuscutae, rhizoma atractylodis, poria, folium ginkgo, herba epimedii and red sugar.The traditional Chinese medicine composition can relieve arteriosclerosis, soften coronary vessels, expand arteriole and promote recanalization of blood vessels in the blocking state; the blood flow volume entering microcirculation is increased, the blood flow velocity is increased, microcirculation is improved, and revascularization of infarct myocardium is promoted; expression of vascular endothelial cell growth factors is improved, endothelial cell migration is promoted, surface integrated activity of endothelial cells is improved, proliferation of microvascular endothelial cells is promoted, a lumen structure is formed, new blood vessels are regenerated, and the effect of establishing coronary collateral circulation is achieved.

The present invention belongs to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for adjuvantly treating the hemorrhagic stroke. The traditional Chinese medicine composition is prepared from the following raw medicine materials in parts by weight: 3-10 parts of pseudo-ginseng, 3-10 parts of cattail pollen, 3-10 parts of rhizoma bletillae, 3-6 parts ofcarbonized hair, 2-5 parts of scorpion, 3-10 parts of rhizoma gastrodiae, 10-15 parts of uncaria rhynchophylla, 15-20 parts of sea-ear shell, 10-15 parts of chrysanthemum, 1-3 parts of antelope horn,1.5-6 parts of arisaema cum bile and 10-15 parts of plantain seed. The composition has the double regulating effects of stopping bleeding and dissolving stasis, not only can stop bleeding without stasis, but also can dissolve the stasis without bleeding, thereby effectively making up for the defect that western medicine is easy to cause thrombus during stopping bleeding. The composition is used for the auxiliary treatment of the hemorrhagic stroke caused by cerebral arteriole bleeding because of high blood pressure, cerebral arteriosclerosis, cerebral arteritis, cerebral bottom aneurysm or cerebral artery and vein deformity, and the like and has unexpected good effect.

The invention discloses gelatin compound antithrombotic blood and a preparation method thereof. The compound antithrombotic blood is prepared by mixing gelatin, Yunnan Baiyao and hemagglutinase. According to the blood stopping liquid, gelatin and hemagglutinase are taken as raw materials and Yunnan Baiyao as auxiliary materials, so on one hand, the hemostatic effect is prolonged, on the other hand, the blood stopping liquid has the effects of diminishing inflammation, diminishing swelling, promoting blood circulation, removing blood stasis and relieving pain, and later-period wound tissue rehabilitation is facilitated. Clinical tests prove that by applying the gelatin compound blood stopping liquid, embolism hemostasis at the capillary network level and the arteriovenous network level in awound tissue can be achieved, embolism is effectively targeted, the remaining functions of organs are protected, and the embolism effect at the arteriovenous level is superior to that of PVA and a micro-spring ring.

The invention relates to an application of bexarotene (4-[1-(5, 6, 7, 8-tetrahydro-3, 5, 5, 8, 8-pentamethyl-2-naphthyl) vinyl] benzoic acid) or / and a pharmaceutically acceptable salt thereof in preparation of anti-pulmonary arterial hypertension drugs. The chemical structural formula of bexarotene is shown as a formula I in the specification. According to the application, rat pulmonary artery smooth muscle cells are adopted for investigating the smooth muscle cell proliferation and migration inhibiting effect of bexarotene, and the result shows that bexarotene can obviously inhibit PASMCs proliferation and migration. The monocrotaline-induced rat pulmonary arterial hypertension model is adopted to investigate the anti-pulmonary arterial hypertension vascular remodeling of the bexarotene,and the result shows that the oral administration of the bexarotene can significantly inhibit the increase of the pulmonary arterial pressure and the right ventricular systolic pressure of rats, significantly reduce the NT-proBNP level in the rat plasma, can obviously inhibit thickening of pulmonary artery intima media and reduce the narrow level of pulmonary arteriole lumens, and a safe, effective and economical solution is provided for prevention and treatment of pulmonary arterial hypertension and pulmonary vascular remodeling.