115 results about "Bone strength" patented technology

The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.

The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.

This invention relates to a bone measurement method for measuring a bone shape, structure and architecture on the basis of the tomographic images of a test bone or joint, in more detail, to a bone measurement method characterized by having a template image extraction step for obtaining a wholly continued template image of a bone inner portion surrounded by a cortical bone from the binary image of a test bone cross section, and separating a cortical bone and a cancellous bone by the product of said template image and said binary image, as a bone measurement method which enables the automatic, high-speed and repeatable separation of a cortical bone and a cancellous bone on the basis of the binary image of a test bone or joint cross section and by which a separated three-dimensional image of the cortical bone portion and the cancellous bone portion is obtained as the bases for a non-invasive analyses of three-dimensional bone structure, bone strength, and the like.

A novel approach for analyzing a patient's body part of interest to assess bone strength and / or risk of future fracture includes obtaining a priori information regarding the body part of interest, performing X-ray absorptiometric scans of the patient's body part of interest and collecting X-ray absorptiometry data from the scans, constructing a three-dimensional model of the patient's body part of interest, by utilizing the a priori information along with the X-ray absorptiometric data, and performing measurements of various geometric parameters on the three-dimensional model for determining geometric and structural properties.

The invention relates to health food for enhancing human immunity and increasing bone mineral density and a preparation method thereof; the health food of the invention comprises the following components: hyaluronic acid, glucosamine, collagen, kudzu root extracts, chondroitin sulfate, vitamins, calcium, etc; because of the embedding processing of hyaluronic acid, the defect of property change of hyaluronic acid due to moisture absorption and influence of environmental factors is overcome; the health food prepared by the organic combination of the embedded hyaluronic acid with glucosamine, collagen, plant extracts, vitamins, mineral matter and the like has functions and effects which can supplement each other, has the effects of lubricating joints, increasing bone mineral density, and enhancing bone strength during long-term administration, and also has the functions of delaying aging, removing freckles and beautifying faces, and the like; the health food of the invention can be prepared into powder, granules, tablets, capsules, is convenient for carrying and taking, has stable and lasting efficacy, has no side effects, and is an ideal health food of patients with hypoimmunity and osteoporosis.

Methods and apparatuses for advanced, multiple-projection, dual-energy X-ray absorptiometry scanning systems include combinations of a conical collimator; a high-resolution two-dimensional detector; a portable, power-capped, variable-exposure-time power supply; an exposure-time control element; calibration monitoring; a three-dimensional anti-scatter-grid; and a gantry-gantry base assembly that permits up to seven projection angles for overlapping beams. Such systems are capable of high precision bone structure measurements that can support three dimensional bone modeling and derivations of bone strength, risk of injury, and efficacy of countermeasures among other properties.

Osteoporosis and the like metabolic bone diseases have a high frequency of causing lumbago and the like pains and bone fracture, due to lowering of the bone strength caused by the reduction of bone mass. Accordingly, great concern has been directed toward the creation of a drug which can increase the bone mass and bone strength by controlling the whole bone metabolism. The pharmaceutical composition or combination product of the invention comprising a non-living body-derived non-peptide osteoblast differentiation promoting compound and a bisphosphonate having a bone resorption inhibitory action is useful as a bone mass increasing inducer which can increase the bone mass and / or bone strength by controlling the bone metabolism.

This invention relates to a pharmaceutical composition for treatment of a bone disease comprising, as an active ingredient, a protein comprising an extracellular cysteine-rich domain, which is from the Frizzled receptor selected from the group consisting of mammalian animal-derived Frizzled 1, Frizzled 2, and Frizzled 7 and has activity of increasing bone mass, bone density, and / or bone strength, or a mutant of such domain having sequence identity of 85% or higher to the amino acid sequence of the domain and having activity of increasing bone mass, bone density, and / or bone strength, or a vector comprising a nucleic acid encoding the protein.

The invention provides a method and a kit for administering bone cement to the interior cavity of a bony member to enhance bone strength, stabilizing an existing fracture thus reducing susceptibility of the bone to further fracture and / or collapse. The method and kit may include additional components, such as, bone growth enhancing agents, radiopaque components or the like.

In some aspects, the present invention is a medical implant with an independent endplate structure that can stimulate bone or tissue growth in or around the implant. When used as a scaffold for bone growth, the inventive structure can increase the strength of new bone growth. The independent endplate structures generally include implants with endplates positioned on opposite sides of the implant and capable of movement independent of one another. In most examples, the endplates have a higher elastic modulus than that of the bulk of the implant to allow the use of an implant with a low elastic modulus, without risk of damage from the patient's bone.A method of designing independent endplate implants is also disclosed, including ranges of elastic moduli for the endplates and bulk of the implant for given implant parameters. Implants with elastic moduli within the ranges disclosed herein can optimize the loading of new bone growth to provide increased bone strength.

A bone strength diagnostic device comprises oscillators, a determination index calculator, a tracking start point setting component, and a tracking execution component. A plurality of the oscillators are disposed in a line to acquire echo signals of a transmitted ultrasound beam. The determination index calculator calculates a determination index expressing a probability that the echo signal is a reflected wave from the surface of a cortical bone. The tracking start point setting component sets a tracking start point at a signal waveform timing corresponding to the echo signal for which the determination index satisfies a specific condition and that is received by one of the plurality of oscillators. The tracking execution component successively sets tracking points for the echo signals acquired from other oscillators using the tracking start point as an origin.

The invention relates to the field of medical food and discloses an aquatic collagen peptide food used for adjuvant therapy of osteoporosis and arthritis. Every 100g of the food contains multiple nutritional ingredients as follows: 9-11g of cod skin collagen protein peptide powder, 4-6g of squid skin collagen protein peptide powder, 2-3g of whey protein powder, 2-3g of soybean protein powder, 9-11g of MCT fat, 2-3g of soybean oil, 58-62g of carbohydrate and other vitamins and microelements. The aquatic collagen peptide food takes cod skin collagen protein peptide powder, squid skin collagen protein peptide powder and whey protein powder as main raw materials and has relatively high digestive absorptivity, and collagen protein peptide can promote bone formation and reinforce a bone collagen structure at low calcium level, so that bone strength is improved; bone metabolism can be improved, and ossification can be enhanced; and bone diseases such as the osteoporosis, hyperostosis and swelling and pain of bone joints can be prevented.

The present invention is an apparatus, method and system for determining cancellous or cortical bone density, cortical bone thickness, bone strength, bone fracture risk, bone architecture and bone quality by acoustically coupling an ultrasound transducer to nearby skin over a bone, reflecting one or more pulses produced by the ultrasound transducer from the bone, and detecting the reflected pulse reflected by the bone, wherein bone porosity and other properties are calculated at a low frequency, a high frequency or both a low and a high frequency.

The invention relates to application of collagen chelate in the preparation of medicament or food for enhancing bone quality. The medicament or food can enhance bone strength, can enhance bone strength and bone density at the same time and can be used for curing and / or preventing osteoporosis. The collagen chelate is a metalloprotein conjugate; compared with calcium carbonate (CaCO3) with the same calcium concentration, the collagen chelate can enhance the bone density by 4.4 percent and enhance the bone strength by 9.9 percent; and compared with a mixture of collagen and calcium carbonate (CaCO3) with the same concentration of collagen and calcium carbonate, the collagen chelate has a more obvious effect.

The invention relates to methods of increasing bone strength in an animal, preferably a mammal. In one aspect, the methods provided by the invention involve administering to the animal strontium and a phytase enzyme. In another aspect, methods are provided for treating or preventing osteoporosis in a subject, the method comprising administering to said individual a phytase enzyme and strontium. Also encompassed are animal feed compositions comprising a phytase enzyme and supplemental strontium and a dietary supplement composition for administration to a human, the composition comprising a phytase enzyme and supplemental strontium.

Disclosed is describes a method of increasing bone strength and / or increasing bone resistance to bending and / or improving bone architecture and / or maintaining bone status in a human, comprising administering to said human a composition comprising a fat source, wherein said fat source is a triglyceride fat source comprising triglycerides with 15-55% palmitic acid moieties out of the total fatty acids, and wherein the level of palmitic acid moieties at the sn-2 position of the glycerol backbone is at least 30% (w / w) of total palmitic acid. Said method is particularly intended for subjects at risk of impaired bone strength. Further disclosed is said fat source, as well as food articles and a commercial package comprising the same.

The invention as disclosed provides a method to increase bone mass without compromising bone strength or quality, through the administration to a host of a compound that binds to the estrogen or androgen receptor without causing hormonal transcriptional activation.

In some aspects, the present invention is a medical implant with an independent endplate structure that can stimulate bone or tissue growth in or around the implant. When used as a scaffold for bone growth, the inventive structure can increase the strength of new bone growth. The independent endplate structures generally include implants with endplates positioned on opposite sides of the implant and capable of movement independent of one another. In most examples, the endplates have a higher elastic modulus than that of the bulk of the implant to allow the use of an implant with a low elastic modulus, without risk of damage from the patient's bone.A method of designing independent endplate implants is also disclosed, including ranges of elastic moduli for the endplates and bulk of the implant for given implant parameters. Implants with elastic moduli within the ranges disclosed herein can optimize the loading of new bone growth to provide increased bone strength.

The invention relates to formula milk powder and a production method thereof. The formula milk powder is prepared from the following raw materials in parts by weight: 200 to 600 parts of whole milk powder; 200 to 400 parts of skimmed milk powder; 50 to 150 parts of 90 desalted whey protein powder; 30 to 90 parts of OPO grease; 30 to 90 parts of lactose, 0.5-2.5 parts of DHA powder, 1-5 parts of ARA powder, 10-30 parts of fructo-oligosaccharide powder, 10-30 parts of galactooligosaccharide powder, 5-15 parts of spina date seed powder, 10-30 parts of jujube powder, 3-8 parts of anhydrous cream,3-8 parts of a child growth nutrition bag, 0.2-0.8 part of quadruple lactic acid bacteria, and 0.1-0.5 part of hydrolyzed yolk powder. The formula milk powder provided by the invention can significantly improve the gastrointestinal digestive ability of children and improve the sleep quality of children, and can help calcium in milk to be fully absorbed, promote bone and tooth strengthening, improve bone strength and help bone growth, so that children grow higher, stronger and healthier.

The invention discloses a preparation method of a microcarrier-cell compound with induction activity and an application of the compound. The preparation method comprises the following steps: respectively using decalcified bone matrix particles and acellular dermal matrix micro particles to culture bone marrow mesenchymal stem cells for 7-21 days, differentiating into osteoblasts and fibroblasts to obtain an osteoblast-particle compound and a fibroblast-particle compound, and then, mixing evenly. The activity of the seed cells of the prepared product are higher, the product can be used for preparing repair material for treating lacunar bone defect and segmental bone defect, the in vivo repair effect is better, and the in vivo repair effect of tissue-engineered bone for more than two times; supporting cell components are added in the construction process of the tissue-engineered bone to promote the bone formation effect of bone parenchymal cells in bone formation in vivo, the new bone strength, the matrix component content and the calcification extent can be improved for 1.5-2 times, the utilization rate of the seed cells is obviously improved, the type of the bone repair seed cells is enriched, and the bone defect repair effect is greatly improved.

The invention discloses a composite bone plate of carbon fiber and polyether-ether-ketone and a preparation method thereof. The preparation method comprises the following steps: electrostatically spraying polyether-ether-ketone on each layer of carbon fiber cloth, overlapping the carbon fiber cloth in a mold layer by layer, closing the mold, performing mold pressing, cooling and opening the mold to take a product out, cleaning the product with a solvent, drying the product to obtain a block material, and performing CNC (Computer Numerical Control) machining on the block material according to a bone plate design drawing to obtain a bone plate blank; performing bio-safe coating treatment on the surface of the obtained bone plate. The bone plate has high biocompatibility; a biological coating is adopted, so that the biological security of medical implanting is enhanced; mechanical parameters are equivalent to those of a skeleton, so that the strength of the bone plate is closer to actual bone strength, the problem of adaption is solved, and the stress shielding effect caused by stress concentration is avoided; the bone plate has high X-ray penetrability, and is suitable for batch production.

A bone strength measuring instrument and method is provided for obtaining thickness values of cortical bone, cancellous bone and tissue in a human body part by applying an ultrasonic wave to a measured portion of the human body. Ultrasonic transmitters and receivers can be positioned in contact with the human body to provide a set thickness for the human body while processing the received signals transmitted through and reflected from the human body portions to determine a first wave higher in speed and a second wave lower in speed. Prior to making the measurements, a preliminary measurement procedure can be utilized to optimize the desired measurement site. An acoustic speed of the second wave in a cancellous bone can be assumed to be constant and transit times can be calculated and respective thickness values of the soft tissue of cortical bone and cancellous bone can be determined to indicate the bone strength.

In some aspects, the present invention is a medical implant with an independent endplate structure that can stimulate bone or tissue growth in or around the implant. When used as a scaffold for bone growth, the inventive structure can increase the strength of new bone growth. The independent endplate structures generally include implants with endplates positioned on opposite sides of the implant and capable of at least some movement relative to one another. In most examples, the endplates have a higher elastic modulus than that of the bulk of the implant to allow the use of an implant with a low elastic modulus, without risk of damage from the patient's bone.A method of designing independent endplate implants is also disclosed, including ranges of elastic moduli for the endplates and bulk of the implant for given implant parameters. Implants with elastic moduli within the ranges disclosed herein can optimize the loading of new bone growth to provide increased bone strength.

Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

The invention provides a method and a kit for administering bone cement to the interior cavity of a bony member to enhance bone strength, stabilizing an existing fracture thus reducing susceptibility of the bone to further fracture and / or collapse. The method and kit may include additional components, such as, bone growth enhancing agents, radiopaque components or the like.

The invention discloses an opto-acoustic and ultrasonic dual-mode osteoporosis detection method and a detection device. The detection device is composed of two parts, namely a host machine and a probe, wherein the host machine comprises a laser device, a laser modulator, a collimating and coupling unit, a display module, an opto-acoustic mode changeover switch, an ultrasonic signal driver and a processor; the probe is composed of an acoustic emission focusing probe, a pre-amplifier, an ultrasonic transducer array and a transparent colloid; and the transparent colloid is attached on human skin. The device disclosed by the invention integrates opto-acoustic and ultrasonic advantages and solves the problem that an existing bone quality assessment DXA (dual X ray absorptiometry) cannot provide bone collagen information, while bone quality is determined by bone density and bone collagen, in which the bone density determines bone strength and the content of the bone collagen determines bone toughness; and a bone quality assessment capacity can be significantly improved by virtue of an opto-acoustic / ultrasonic imaging technology. The detection method and the detection device disclosed by the invention have the obvious advantages of being noninvasive, free from radiation, low in detection cost, accurate in assessment and the like.

The invention belongs to the technical field of health-caring products, provides a chitosan oligosaccharide bone-fortifying health-caring product and a preparation method thereof and particularly relates to the chitosan oligosaccharide bone-fortifying health-caring product. The health-caring product is prepared by mixing chitosan oligosaccharide, extract of eucommia ulmoides, calcium carbonate, vitamin D3, glucosamine and chondroitin sulfate to obtain a mixture, performing granulation, drying granules, and finally adding an auxiliary material in a proper amount, mixing the mixture uniformly and filling capsules with the granules, and packaging the capsules to obtain the capsules for increasing bone density. The chitosan oligosaccharide composition is safe, is free of toxic and side effects, can tonify kidney and reinforce bone, can maintain bone strength and reduce bone fragility, can improve and increase bone density, promotes calcium absorption and generation of collagen in human body, can deeply regulate bone joints and repair bone tissue and has the significant effects of lubricating joint and strengthening tendon and bone. The chitosan oligosaccharide health-caring product can prevent and improve osteoporosis, can recover health of bone in osteoporosis, is safe and effective and has positive social significance.

The invention discloses a detachable multi-position ultrasonic bone strength instrument, comprising an ultrasonic probe box and a detachable probe module, wherein multiple ultrasonic probes with different frequencies and different sizes are mounted in the ultrasonic probe box, the detachable probe module comprises a clamping device and a force sensor, the clamping device is used for mounting the ultrasonic probes, the force sensor is used for detecting the contact force between the ultrasonic probes and a measured position, the output port of the detachable probe module is connected with an integrated signal acquisition and processing module through a signal wire, and the integrated signal acquisition and processing module is in bidirectional connection with a man-machine interaction module. According to the detachable multi-position ultrasonic bone strength instrument, corresponding ultrasonic probes are mounted according to different to-be-measured positions of a human body, the center frequency and the size of each ultrasonic probe are set according to the specific measured position of the human body, so that the ultrasonic probes are matched with the measured positions reasonably, one bone strength instrument can simultaneously detect the bone strength of multiple positions of the human body, and the measurement result can indicate the overall bone strength of the human body more accurately.

A system and method for the use of the results from a structural analysis of a patient's bone from a clinical scan, to be used clinically to manage patients in a widespread and consistent fashion.